Liver Fluke-Associated Biliary Tract Cancer.

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Annotation Summary

Term Occurence Count Dictionary
ascariasis 1 infectiousdiseases
clonorchiasis 1 infectiousdiseases
enterobiasis 1 infectiousdiseases
hepatitis B 1 infectiousdiseases
leptospirosis 1 infectiousdiseases
opisthorchiasis 3 infectiousdiseases
praziquantel 6 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
praziquantel 9551 for treatment of fluke infection including opisthorchiasis and clonorchiasis. The standard dose of praziquantel is 75 mg/kg in three divided doses for 1 day, which results in an egg reduction rate of 98% to 99% for
praziquantel 9738 reduction rate of 98% to 99% for both O. viverrini and C. sinensis infection.[40] The adverse events of praziquantel treatment, such as dizziness, headache, and nausea, are uncommon.Several novel agents for treatment
praziquantel 10447 against both O. viverrini[41],[43] and C. sinensis[44] was 98% to 99%, which was comparable to that of praziquantel but with less adverse effects. The most common adverse effects of tribendimidine were dizziness, vertigo,
praziquantel 20883 and the mRNA expression levels of IL-1, IL-6 and TNF-α.[86]5. Posttreatment effectA treatment with praziquantel reduced iNOS-dependent DNA damage in O. viverrini-infected hamsters by decreased expression of NF-κB
praziquantel 21613 confirmed by a recent study in hamster model with three cycles of O. viverrini infection and treatment with praziquantel .[90] In summary, the role of repeated treatment on carcinogenesis of CCA remains controversial.FUTURE
praziquantel 23669 facilitate the uninterrupted cycle of O. viverrini infection. In spite of available treatment with praziquantel , the prevalence of O. viverrini is still high as re-infection occurs frequently after treatment. A combination
Select Disease Character Offset Disease Term Instance
ascariasis 10094 possesses activities against not only liver fluke but also some intestinal roundworm such as hookworms, ascariasis and enterobiasis.[41],[42] Patients in endemic areas with co-infection of liver fluke and roundworms
clonorchiasis 9515 INFECTIONPraziquantel is a drug of choice for treatment of fluke infection including opisthorchiasis and clonorchiasis . The standard dose of praziquantel is 75 mg/kg in three divided doses for 1 day, which results in an
enterobiasis 10109 activities against not only liver fluke but also some intestinal roundworm such as hookworms, ascariasis and enterobiasis .[41],[42] Patients in endemic areas with co-infection of liver fluke and roundworms would benefit from
hepatitis B 4429 CCA.[9] Further, previous series showed several diseases associated with the development of CCA including hepatitis B and C infection, cirrhosis, obesity and diabetes mellitus.[9] In Thailand, the highest percentage of
leptospirosis 23089 equator line would be too hot to flourish.[91] Because of a close association between opisthorchiasis and leptospirosis , the awareness of both diseases should be raised in the potentially migrated habitat area.[92] The level
opisthorchiasis 7252 reaction (PCR)-based method for detection of liver fluke’s genetic materials in stool could diagnose opisthorchiasis in 28.6% to 76.6% of cases in which stool microscopic examinations were negative.[25]–[27] Moreover,
opisthorchiasis 9495 OF LIVER FLUKE INFECTIONPraziquantel is a drug of choice for treatment of fluke infection including opisthorchiasis and clonorchiasis. The standard dose of praziquantel is 75 mg/kg in three divided doses for 1 day, which
opisthorchiasis 23069 habitat around the equator line would be too hot to flourish.[91] Because of a close association between opisthorchiasis and leptospirosis, the awareness of both diseases should be raised in the potentially migrated habitat

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