Molecular diagnostics in medical mycology

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Annotation Summary

Term Occurence Count Dictionary
infectious disease 3 infectiousdiseases
meningitis 3 infectiousdiseases
phaeohyphomycosis 1 infectiousdiseases
fungal meningitis 2 infectiousdiseases
histoplasmosis 2 infectiousdiseases
candidemia 1 infectiousdiseases
coccidioidomycosis 1 infectiousdiseases
cryptococcosis 2 infectiousdiseases
invasive aspergillosis 3 infectiousdiseases
tuberculosis 1 infectiousdiseases
AIDS 2 infectiousdiseases
aspergillosis 3 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
AIDS 3965 medical treatment that patients may experience today. Patient groups at high risk include those with AIDS , those receiving immunosuppressive chemotherapy, transplant recipients, certain surgeries, and those
AIDS 4682 cases being found in sub-Saharan Africa. Unfortunately, in this region, cryptococcosis may kill more AIDS patients annually than tuberculosis[12], which reflects deficiencies in both diagnosis and treatment
aspergillosis 6540 patients[23]. One of the most crucial predictors of clinical outcome in patients with acute invasive aspergillosis is time to diagnosis, which is particularly challenging for the Aspergilli because these fungi rarely
aspergillosis 33129 preparation. In fact, a positive blood culture is not considered a factor for the diagnosis of invasive aspergillosis because blood rarely harbors culturable elements[47]. Fungi also are problematic diagnostic targets
aspergillosis 41797 sensitive because the RNA target can be present in thousands of copies. In a recent study of invasive aspergillosis for example, Zhao et al. found NASBA to correlate well with an FDA-approved serum 1,3-β-D-glucan kit[54].
candidemia 4996 with significant morbidity, mortality, and increased healthcare costs[13]. In fact, mortality due to candidemia may increase by 20% after only a 12-hour delay in the initiation of treatment following collection of
coccidioidomycosis 7838 to diagnose if a patient is not from an endemic area where they were infected, such as in cases of coccidioidomycosis , due to lack of familiarity with the fungus or lack of suspicion of a specific fungus as an etiologic
cryptococcosis 4497 are commonly associated with invasive mycoses include Cryptococcus and Candida species. New cases of cryptococcosis are estimated to exceed more than 500,000 per year[11] with most new cases being found in sub-Saharan
cryptococcosis 4653 per year[11] with most new cases being found in sub-Saharan Africa. Unfortunately, in this region, cryptococcosis may kill more AIDS patients annually than tuberculosis[12], which reflects deficiencies in both diagnosis
fungal meningitis 14188 sophisticated equipment, or technologies that enable the correct identification. For example, an outbreak of fungal meningitis in patients receiving steroid preparations contaminated with the rare pathogen Exserohilum rostratum
fungal meningitis 14459 deaths[27] (Box 2). The etiologic agent was identified only after a clinician made the link between a case of fungal meningitis and an epidural injection a number of weeks earlier[28]. Similarly, in 2011 a tornado hit Joplin, Missouri,
histoplasmosis 8324 cave were hospitalized immediately after rescue, due in part to concerns that they were at risk for histoplasmosis [26]. Histoplasma capsulatum infections can be very slow and require 1-2 weeks or more of incubation.
histoplasmosis 8471 infections can be very slow and require 1-2 weeks or more of incubation. In the case of these patients, histoplasmosis is a well-known disease that can be contracted by people who spend time in caves. If they had become
infectious disease 30793 validated, and used primarily for in-house testing within individual laboratories[45],[46]. In the field of infectious disease , LDTs, including molecular-based assays, are widely used due to the unavailability of FDA-cleared or
infectious disease 31705 clinical picture for proper interpretation and patient care. As with all molecular-based assays in infectious disease s, the result must be correlated with the clinical picture or risk factors that the patient has for particular
infectious disease 49580 disease[74].WGS is now moving from the research arena to clinical laboratories so its capabilities as a frontline infectious disease diagnostic tool are not yet fully recognized. With advances in instrumentation, bioinformatics, and
invasive aspergillosis 6531 high risk patients[23]. One of the most crucial predictors of clinical outcome in patients with acute invasive aspergillosis is time to diagnosis, which is particularly challenging for the Aspergilli because these fungi rarely
invasive aspergillosis 33120 sample preparation. In fact, a positive blood culture is not considered a factor for the diagnosis of invasive aspergillosis because blood rarely harbors culturable elements[47]. Fungi also are problematic diagnostic targets
invasive aspergillosis 41788 extremely sensitive because the RNA target can be present in thousands of copies. In a recent study of invasive aspergillosis for example, Zhao et al. found NASBA to correlate well with an FDA-approved serum 1,3-β-D-glucan kit[54].
meningitis 14195 equipment, or technologies that enable the correct identification. For example, an outbreak of fungal meningitis in patients receiving steroid preparations contaminated with the rare pathogen Exserohilum rostratum
meningitis 14466 2). The etiologic agent was identified only after a clinician made the link between a case of fungal meningitis and an epidural injection a number of weeks earlier[28]. Similarly, in 2011 a tornado hit Joplin, Missouri,
meningitis 61010 (bioMerieux)Nested multiplex PCR with DNA melt-curve analysis•Blood culture ID (BCID; for Candida species) and meningitis /encephalitis (ME; for Cryptococcus) panels available•ME panel can detect Cryptococcus directly in
phaeohyphomycosis 27708 fungi that display similar phenotypes. The general description of the type of disease they cause is phaeohyphomycosis , which includes many species of Exophiala. However, E. dermatitidis is a pulmonary colonizer that is
tuberculosis 4710 sub-Saharan Africa. Unfortunately, in this region, cryptococcosis may kill more AIDS patients annually than tuberculosis [12], which reflects deficiencies in both diagnosis and treatment in undeveloped countries. Candida species

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