Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs

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AIDS 2 infectiousdiseases
romidepsin 2 infectiousdiseasesdrugs

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Select Drug Character Offset Drug Term Instance
romidepsin 4476 HIV reservoir. In particular, pan-histone deacetylase inhibitors (HDACi), such as vorinostat [[6]], romidepsin [[7]], and panobinostat [[8]], are currently among the most promising classes of LRAs. Through the inhibition
romidepsin 7862 are reporting associations between treatment with selected LRAs and CTL dysfunction. In particular, romidepsin , panobinostat, and vorinostat appeared to reduce the production of cytokines interferon-γ, tumor necrosis
Select Disease Character Offset Disease Term Instance
AIDS 387 Simon Fraser University, Burnaby, BC V5A 1S6, Canada3British Columbia Centre for Excellence in HIV/ AIDS , Vancouver, BC V6Z 1Y6, CanadaPublication date (epub): 11/2018Publication date (collection): 12/2018AbstractFinding
AIDS 14427 dampening the local immune response against HIV-infected cells. Transgenic mice expressing Nef display AIDS -like pathologies [[73]], raising the possibility that the induction of Nef by “shock and kill” methods

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