Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature

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Term Occurence Count Dictionary
chloramphenicol 1 infectiousdiseasesdrugs
histoplasmosis 14 infectiousdiseases
pneumonia 1 infectiousdiseases
tuberculosis 3 infectiousdiseases
American histoplasmosis 1 infectiousdiseases
aspergillosis 2 infectiousdiseases
Voriconazole 3 infectiousdiseasesdrugs
amoxicillin 1 infectiousdiseasesdrugs
gentamicin 1 infectiousdiseasesdrugs
AIDS 5 infectiousdiseases
Itraconazole 4 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Itraconazole 11978 opacification), frontal sinuses (partial opacification)AMBComplete cure27CLL Chronic Lymphocytic Leukaemia, ITR Itraconazole , AMB Amphotericine B, POS PosaconazoleDiscussions and conclusionsIn this study, fungal rhinosinusitis
Itraconazole 20836 previously reported cases consisted in a long-term administration of Amphotericin B (cases 1, 6, 8), Itraconazole (cases 2, 3,4,7) and Posaconazole (case 5) leading to resolution of symptoms. No local surgery was required
Itraconazole 21212 histoplasmosis treatment are Amphotericin B (including liposomal and lipid complex formulations) and Itraconazole [[12]]. Posaconazole and Voriconazole also demonstrated in vitro activity against H. capsulatum and
Itraconazole 22171 in France, without any exception for French Guiana [[33]]. In opposition, in USA, a prophylaxis with Itraconazole (200 mg daily) is recommended in HIV infected patients with CD4 cell counts < 150 cells/mm3 in specific
Voriconazole 6762 with a severe sepsis-like infection, after a prolonged well-supported fever. Antifungal therapy with Voriconazole was introduced due to presumption of an Aspergillus spp. maxillary infection that may be associated
Voriconazole 21250 Amphotericin B (including liposomal and lipid complex formulations) and Itraconazole [[12]]. Posaconazole and Voriconazole also demonstrated in vitro activity against H. capsulatum and most studies have reported success with
Voriconazole 21409 capsulatum and most studies have reported success with these azoles [[24], [32]]. In present case, Voriconazole efficiency was difficult to evaluate as treatment was introduced too late with a curative dose for aspergillosis
amoxicillin 4747 reported medical consultation three months before for febrile nasal obstruction and cough treated by amoxicillin -clavulanic acid without ameliorations. She lived in French Guiana for 20 years.Diagnosis of HIV infection
chloramphenicol 7430 and from cervical adenopathy biopsy after 20 and 15 days of culture, respectively using Sabouraud/ chloramphenicol /gentamicin agar media at 30 °C. The other fungal cultures (bone marrow, liver biopsy, blood, urine,
gentamicin 7446 cervical adenopathy biopsy after 20 and 15 days of culture, respectively using Sabouraud/chloramphenicol/ gentamicin agar media at 30 °C. The other fungal cultures (bone marrow, liver biopsy, blood, urine, BAL and expectorations)
Select Disease Character Offset Disease Term Instance
AIDS 2827 (Dematiaceous species, Rhizopus spp., Fusarium spp and Scedosporium spp.) have been reported mainly in HIV- AIDS patients [[5], [6], [9], [10]]. Few reports involving Histoplasma capsulatum (HC), an environmental
AIDS 4042 French Guiana, histoplasmosis is known as a major opportunistic infection and one of the main causes of AIDS -related death, along with tuberculosis [[14], [16]–[18]]. First case of Histoplasmosis sinusitis was
AIDS 20183 antigens in sera have also been reported to be useful for the diagnosis of disseminated histoplasmosis in AIDS patients in endemic areas where Histoplasma EIA is not available [[29], [30]]. Unfortunately, the test
AIDS 21914 demonstrated due to multiple co-morbidities.In conclusion, histoplasmosis is a serious fatal risk for the AIDS -patients, requiring quick and reliable routine diagnostic methods. Moreover, there is a lack of specific
AIDS 22360 < 150 cells/mm3 in specific areas of endemicity [[3]]. A particular attention has to be given in AIDS -patients with sinusitis symptoms in H. capsulatum endemic areas such as in French Guiana. Despite the
American histoplasmosis 329 11/2018Publication date (pmc-release): 11/2018Publication date (collection): /2018AbstractBackground American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have
aspergillosis 6890 due to presumption of an Aspergillus spp. maxillary infection that may be associated with pulmonary aspergillosis . Antimicrobial therapy with Piperacillin-tazobactam was introduced to cover a potential bacterial pulmonary
aspergillosis 21521 efficiency was difficult to evaluate as treatment was introduced too late with a curative dose for aspergillosis and the patient had too many concomitant life-threatening co-infections such as lymphoma and disseminated
histoplasmosis 338 11/2018Publication date (pmc-release): 11/2018Publication date (collection): /2018AbstractBackgroundAmerican histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have
histoplasmosis 434 /2018AbstractBackgroundAmerican histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infections. In
histoplasmosis 1096 Acquired Immunodeficiency Syndrome due to Human Immunodeficiency Virus complicated by a disseminated histoplasmosis with a death ending. Diagnosis relied on CT-Scan imaging and on both direct examination of H. capsulatum
histoplasmosis 1554 occurred mostly in HIV-immunocompromised patients and for three cases as a sinusitis with disseminated histoplasmosis . Even if this is a rare clinical presentation, its diagnosis is crucial as it could represent an early
histoplasmosis 3561 visceral involvement through the bloodstream [[11]–[15]]. This can lead to progressive disseminated histoplasmosis that can be fatal when therapy is delayed and when misdiagnosed [[11], [14]]. Though, rapid and accurate
histoplasmosis 3706 is delayed and when misdiagnosed [[11], [14]]. Though, rapid and accurate biological diagnostic of histoplasmosis is challenging as the absence of specific symptoms can lead to possible confusion with other opportunistic
histoplasmosis 3953 tuberculosis [[16]]. This is even more obvious in case of atypical localizations. In French Guiana, histoplasmosis is known as a major opportunistic infection and one of the main causes of AIDS-related death, along
histoplasmosis 8949 database using the keywords “Histoplasma capsulatum”, “sinusitis”, “rhinosinusitis”, “ histoplasmosis ”. Only cases in which imaging confirmed sinusitis and H. capsulatum was documented by histopathologic
histoplasmosis 17061 sinus fungus ball [[8], [10]].Challenge in the diagnosis and utility of new diagnostic toolsBecause histoplasmosis can have an extended incubation period and may goes undiagnosed for a long time before the worsening
histoplasmosis 20165 galactomannan antigens in sera have also been reported to be useful for the diagnosis of disseminated histoplasmosis in AIDS patients in endemic areas where Histoplasma EIA is not available [[29], [30]]. Unfortunately,
histoplasmosis 20658 [[31]]. This report highlights the need of new biological tools to improve and accelerate diagnosis of histoplasmosis .Treatment and outcomeAntifungal treatment of sinusitis in the previously reported cases consisted in
histoplasmosis 21111 require endoscopic sinus surgery [[8], [10]]. No death was reported. Recommended antifungal agents for histoplasmosis treatment are Amphotericin B (including liposomal and lipid complex formulations) and Itraconazole [[12]].
histoplasmosis 21867 capsulatum infection and death could not be demonstrated due to multiple co-morbidities.In conclusion, histoplasmosis is a serious fatal risk for the AIDS-patients, requiring quick and reliable routine diagnostic methods.
histoplasmosis 22043 quick and reliable routine diagnostic methods. Moreover, there is a lack of specific recommendation for histoplasmosis prophylaxis in France, without any exception for French Guiana [[33]]. In opposition, in USA, a prophylaxis
pneumonia 6172 of yeast and a gram-negative bacterium further identified in culture as Candida albicans, Klebsiella pneumonia and Pseudomonas fluorescens. Histopathology examination including Gomory Methenamine-Silver Grocott
tuberculosis 3853 specific symptoms can lead to possible confusion with other opportunistic microbial agents such as tuberculosis [[16]]. This is even more obvious in case of atypical localizations. In French Guiana, histoplasmosis
tuberculosis 4073 known as a major opportunistic infection and one of the main causes of AIDS-related death, along with tuberculosis [[14], [16]–[18]]. First case of Histoplasmosis sinusitis was reported in 1993 from California, USA
tuberculosis 11597 biopsy)Hard palate (destruction), right maxillary sinus (opacification)ITRImprovement268Male/39HIV, tuberculosis MoroccoFever, Cough, Nasal congestion, Rhinorrhea, Epistaxis, Headhache, Skin rash (papular and nodular),

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