Potential therapy strategy: targeting mitochondrial dysfunction in sepsis

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septic shock 4 infectiousdiseases

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septic shock 504 Severe patients always present with uncorrectable hypotension or hyperlactacidemia, which is defined as septic shock . The new definition emphasizes dysregulation of the host response and multiple organ dysfunction, which
septic shock 1813 life-threatening organ dysfunction caused by a dysregulated host response to infection. Severe patients with septic shock require vasopressors to maintain a mean arterial pressure of 65 mmHg in the absence of hypovolemia
septic shock 25550 clinical trial indicated that levosimendan might improve cellular metabolic alterations in patients with septic shock [[91]]. The effect of levosimendan is not specific to regulating mitochondrial channels, and the protective
septic shock 32043 [[106]].ConclusionsMitochondrial dysfunction is critically involved in the pathogenesis of sepsis, especially severe sepsis and septic shock and is a predominant factor associated with poor outcome, including multiple organ failure and even

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