Evidence for the effectiveness of chlorhexidine bathing and health care-associated infections among adult intensive care patients: a trial sequential meta-analysis

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
chlorhexidine 10 infectiousdiseasesdrugs
pneumonia 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
chlorhexidine 64 Title: BMC Infectious DiseasesEvidence for the effectiveness of chlorhexidine bathing and health care-associated infections among adult intensive care patients: a trial sequential
chlorhexidine 894 Care Med 34:2084-9, 2006; Zimlichman et al., JAMA Intern Med 173:2039-46, 2013). Daily bathing with chlorhexidine gluconate (CHG) has been shown to decrease the risk of infection in the ICU (Loveday et al., J Hosp
chlorhexidine 1446 trial sequential meta-analysis aims to explore the current status of evidence for the effectiveness of chlorhexidine (CHG) bathing, in adult intensive care patients, to reduce hospital acquired infections, and address
chlorhexidine 1701 trials?MethodsA systematic literature search was undertaken to identify trials assessing the effectiveness of chlorhexidine bathing to reduce risk of infection, among adult intensive care patients. With particular focus on:
chlorhexidine 2256 Sequential Analysis (TSA) was used to describe the current status of evidence for the effectiveness of chlorhexidine (CHG) bathing, in adult intensive care patients, to reduce hospital acquired infections.ResultsFive
chlorhexidine 3751 cost of care, and in some cases an increased risk of hospital death [[1]–[4]]. Daily bathing with chlorhexidine gluconate has been suggested as an effective intervention to reduce the risk of infection during an
chlorhexidine 7034 ICU days at risk.Statistical methodsIndividual study and combined estimates of the effectiveness of chlorhexidine bathing to prevent infections (Incidence Rate Ratios (IRR)) are presented as forest plots [[18]]. Both
chlorhexidine 14163 monitoring boundaries have not.Fig. 4Trial sequential analysis of evidence for the effectiveness of chlorhexidine (CHG) bathing, in adult intensive care patients, to reduce infection. BSI = Blood Stream Infection,
chlorhexidine 22322 Moreover, even though CHG bathing aims to reduce HAI, it has been suggested it may promote the emergence of chlorhexidine -resistance, and increase gram-negative organism bacteraemia [[9]]. However, large studies have failed
chlorhexidine 22823 mortality.Importantly, a previous met-analysis of CHG bathing by Afonso et al [[30]] found that the effect of chlorhexidine gluconate-impregnated washcloth bathing may be unequal for Gram-positive BSIs versus Gram-negative BSIs
Select Disease Character Offset Disease Term Instance
pneumonia 16217 both studies, the TSA upper O’Brien-Fleming monitoring boundaries have not.Ventilator associated pneumonia (VAP)Four randomised trials assessed VAP as a primary outcome of interest (10,564 patients), daily bathing

You must be authorized to submit a review.