Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

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Annotation Summary

Term Occurence Count Dictionary
diarrhea 1 infectiousdiseases
metronidazole 2 infectiousdiseasesdrugs
sucralfate 3 infectiousdiseasesdrugs
capsaicin 3 infectiousdiseasesdrugs
dexamethasone 1 infectiousdiseasesdrugs

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Select Drug Character Offset Drug Term Instance
capsaicin 53481 SOD and nitric oxide levels [[105]]. Moreover, it was also proposed that anacardic acid may activate capsaicin -sensitive gastric afferents, stimulate endogenous prostaglandins and nitric oxide and open K+ ATP channels
capsaicin 64381 antiulcer activity through opioid and α2-adrenergic receptors and primary afferent neurons sensitive to capsaicin in gastric ulcers induced by ethanol, acidified ethanol, acetic acid or indomethacin [[169]]. Anthocyanins
capsaicin 88197 indomethacin100 mg/kgOpioid receptors, α2-adrenergic receptors and primary afferent neurons sensitive to capsaicin [[169]]GarcinolGarcinia indicaAcute ulceration in rats induced by indomethacin and water immersion stress200
dexamethasone 43075 mg/kg) showed marked antiulcer and ulcer healing activities against ethanol, diclofenac sodium and dexamethasone induced ulcer rat models [[86]]. Moreover, methanol bark extract (100, 200, 300 and 400 mg/kg) showed
metronidazole 61941 reperfusion injury and cysteamine at 7.5 mg/kg [[162]]. α-Pinene also confirmed antibacterial effects on metronidazole -resistant H. pylori at ethanol-induced gastric ulcer, with an EC50 value of 12.32 mg/kg [[158]]. α-Pinene-rich
metronidazole 85760 activity[[157]]α-PinenePistacia atlanticaEthanol-induced gastric ulcer12.32 mg/kg (EC50)Antibacterial activity on metronidazole -resistant H. pylori[[158]]α-Pinene (50.8%), cineole (20.3%), β-pinene (18.3%)Hyptis spicigeraEthanol
sucralfate 37844 important antiulcerogenic activity in rats ulcered with ethanol, being the observed effect similar to sucralfate , a drug that has a protective action on gastric lesion induced by ethanol [[72]]. The authors suggested
sucralfate 51740 both models at 400 mg/kg dose, which is comparable to the standard drugs, ranitidine (50 mg/kg) and sucralfate (100 mg/kg). Moreover, the study showed that the extract exerted both dose- and time-dependent antiulcer
sucralfate 78751 leukotrienes release)Prostaglandins, fatty acids, sulfhydryl compounds, aluminum-containing antacids, sucralfate , bismuth chelate and liquorice[[25],[26]]molecules-23-01751-t002_Table 2Table 2Plant extracts with antiulcerogenic
Select Disease Character Offset Disease Term Instance
diarrhea 63464 pharmacological activities, including as antiallergic, anti-inflammatory, antimicrobial, anti-cancer, anti diarrhea l and antiulcer. Due to the presence of a hydroxyl group(s) in their aromatic ring(s), they possess antioxidant

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