Biomarkers for diagnosis of childhood tuberculosis: A systematic review

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Term Occurence Count Dictionary
pneumonia 1 infectiousdiseases
pulmonary tuberculosis 2 infectiousdiseases
tuberculosis 38 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
pneumonia 24930 reference standard based on clinical or microbiological confirmationLTBI, healthy controls and non-TB pneumonia 0.78 (95%CI:NR)0.96 (95%CI:NR)0.94 (95%CI:NR)972Meets one of the minimal TPP targets for a diagnostic
pulmonary tuberculosis 18223 targets for a diagnostic or triage testNicol, M.[[38]]Urine lipoarabinomannan testing for diagnosis of pulmonary tuberculosis in children: a prospective study2014Lancet Glob HealthSouth AfricaUrineM. tuberculosis cell wall antigen
pulmonary tuberculosis 26812 testWang J.X.[[60]]Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients2015Genet Mol ResChinaPBMCsmicroRNA-31RT-PCR125Clinical diagnostic criteria for paediatric
tuberculosis 53 Title: PLoS ONEBiomarkers for diagnosis of childhood tuberculosis : A systematic reviewAlternative Title: Biomarkers for diagnosis of childhood tuberculosis: A systematic
tuberculosis 143 childhood tuberculosis: A systematic reviewAlternative Title: Biomarkers for diagnosis of childhood tuberculosis : A systematic reviewToyin Omotayo Togun (Conceptualization) (Data curation) (Methodology) (Writing –
tuberculosis 1206 date (epub): 9/2018Publication date (collection): /2018AbstractIntroductionAs studies of biomarkers of tuberculosis (TB) disease provide hope for a simple, point-of-care test, we aimed to synthesize evidence on biomarkers
tuberculosis 3271 AvailabilityAll relevant data are within the paper and its Supporting Information files.IntroductionChildhood tuberculosis (TB) is estimated to constitute approximately 5% of the TB caseload in low TB burden countries compared
tuberculosis 4257 as centrifugation of samples and use of fluorescent microscopy [[7]]. While culture of Mycobacterium tuberculosis (M.tb) in biological samples is more sensitive than smear microscopy, bacteriological confirmation of
tuberculosis 7870 conducted a systematic review of biomarkers and multi-marker biosignatures for diagnosis of active tuberculosis in exclusively paediatric study subjects, defined as age less than 15 years, in studies published between
tuberculosis 8574 database, the search term was transposed as appropriate. The PubMed search term used was as follows:(((( tuberculosis [ti] OR TB[ti]) AND (child*[tw] OR pediat*[tw])) ((("biological markers"[mesh] OR biological marker*[tw]
tuberculosis 17025 TPP targets for triage and/or diagnostic test?COHORT STUDIESChiappini, E.[[35]]Potential role of M. tuberculosis specific IFN-g and IL-2 ELISPOT assays in discriminating children with active or latent tuberculosis2012PLoS
tuberculosis 17126 tuberculosis specific IFN-g and IL-2 ELISPOT assays in discriminating children with active or latent tuberculosis 2012PLoS OneSpainPBMCsCytokine (IL-2)ELISPOT75Case definition according to American Academy GuidelinesLTBI1.00
tuberculosis 17800 targets for a diagnostic or triage testPortevin, D.[[37]]Assessment of the novel T-cell activation marker- tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study2014Lancet
tuberculosis 17843 D.[[37]]Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study2014Lancet Infect DisTanzaniaPBMCsHaematological marker(M.
tuberculosis 17964 children: a prospective proof-of-concept study2014Lancet Infect DisTanzaniaPBMCsHaematological marker(M. tuberculosis -specific CD4+ CD27+ T-cells)ICS/Flow cytometry130CultureORD0.83 (95%CI: 0.59–0.96)0.97(95%CI: 0.89–0.99)NR1863Meets
tuberculosis 18233 diagnostic or triage testNicol, M.[[38]]Urine lipoarabinomannan testing for diagnosis of pulmonary tuberculosis in children: a prospective study2014Lancet Glob HealthSouth AfricaUrineM. tuberculosis cell wall antigen
tuberculosis 18320 of pulmonary tuberculosis in children: a prospective study2014Lancet Glob HealthSouth AfricaUrineM. tuberculosis cell wall antigen (Lipoarabinomannan)ELISA and Lateral Flow Assay535CultureORDELISA: 0.02 (95%CI: 0.00–0.08)LFA:
tuberculosis 18746 LFA does not meet eitherKroidl, I.[[39]]Performance of urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania2015Eur Respir JTanzaniaUrineM. tuberculosis cell wall antigen (Lipoarabinomannan)ELISA and
tuberculosis 18802 urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania2015Eur Respir JTanzaniaUrineM. tuberculosis cell wall antigen (Lipoarabinomannan)ELISA and Lateral Flow Assay132CultureORD and LTBIELISA: 0.44 (95%CI:NR)LFA:
tuberculosis 19134 minimal TPP targets for a triage testTebruegge, M.[[40]]Mycobacteria-Specific cytokine responses detect tuberculosis infection and distinguish latent from active tuberculosis2015Am J Respir Crit Care MedAustraliaPlasmaCytokines(TNF-a/IL-10
tuberculosis 19192 M.[[40]]Mycobacteria-Specific cytokine responses detect tuberculosis infection and distinguish latent from active tuberculosis 2015Am J Respir Crit Care MedAustraliaPlasmaCytokines(TNF-a/IL-10 & TNF-a/IL1-ra)Multiplex140Case definition
tuberculosis 19471 Society/CDCLTBINRNRNR616NACROSS SECTIONAL STUDIESRaqib R.[[41]]Detection of Antibodies Secreted from Circulating Mycobacterium tuberculosis -Specific Plasma Cells in the Diagnosis of Pediatric Tuberculosis2009Clin Vaccine ImmunolBangladeshPBMCsAnti-BCG
tuberculosis 19877 targets for a diagnostic testJenum S.[[42]]Approaching a diagnostic point-of-care test for paediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum2016Sci RepIndiaWhole bloodmRNA
tuberculosis 20135 TIMP2, FPR1, IL4, TGFBR2)dcRT-MLPA transcriptional assay127Clinical case definitions for childhood tuberculosis (under Revised National Tuberculosis Control Programme)Asymptomatic household siblingsNRNR0.88 (95%CI:NR)8839NAIskandar
tuberculosis 20400 Urine Lipoarabinomannan (LAM) Antigen in Childhood Tuberculosis2017J Clin Diagn ResIndonesiaUrineM. tuberculosis cell wall antigen (Lipoarabinomannan)ELISA61Composite reference standard based on clinical or microbiological
tuberculosis 20763 testCASE CONTROL STUDIESSimonney N.[[44]]Analysis of circulating immune complexes (CICs) in childhood tuberculosis : levels of specific antibodies to glycolipid antigens and relationship with serum antibodies2000IJTLDFranceSerumIgG
tuberculosis 21324 of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis2001IJTLDArgentinaSerumAnti rec-Ag16 IgG, IgM and IgAELISA272CultureNon-mycobacterial
tuberculosis 21350 IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis 2001IJTLDArgentinaSerumAnti rec-Ag16 IgG, IgM and IgAELISA272CultureNon-mycobacterial diseasesIgG + IgA:
tuberculosis 21917 for a diagnostic or triage testDayal R.[[47]]Diagnostic Value of Elisa Serological tests in childhood tuberculosis 2006J Trop PediatrIndiaSerumAnti-PGLTb1 IgG; anti ESAT-6 IgGELISA197Composite reference standard based
tuberculosis 23081 eitherSenol G.[[50]]Humoral Immune Response Against 38- and 16-kDa mycobacterial antigens in childhood tuberculosis 2009Pediatr PulmonolTurkeySerumAnti 16kDa IgG + Anti 32kDa IgGELISA72Composite reference standard based
tuberculosis 23463 testLighter-Fisher J.[[51]]Cytokine responses to QuantiFERON peptides, PPD and recombinant ESAT-6 in children with tuberculosis 2010IJTLDUSAPlasmaCytokine (IL-2, TGF-β1 in QFT stimulation assay)Multiplex92Case definitions not specifiedLTBINRNRNR1146NAMueller
tuberculosis 23776 for Tuberculosis during Childhood and Adolescence2011PLoS OneGermanyPBMCsHaematological marker (M. tuberculosis -specific CD4+ CD45RO+ T-cellsco-expressing granulysin)ICS/Flow cytometry59Case definitions not specifiedNTM
tuberculosis 23983 specifiedNTM and healthy controlsNRNRNR718NAThomas T.[[53]]A new potential biomarker for childhood tuberculosis 2011ThoraxBangladeshPlasmaAnti BCG IgGALS/ELISA132Composite reference standard based on clinical or microbiological
tuberculosis 24361 targets for a diagnostic testGourgouillon, N.[[54]]TNF-α/IL-2 ratio discriminates latent from active tuberculosis in immunocompetent children: a pilot study2012Pediatr ResFrancePlasmaCytokines (TNF-α/IL-2 ratio)Multiplex18Case
tuberculosis 24708 triage testVerhagen L.M.[[55]]A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children2013BMC GenomicsVenezuelaWhole blood5-gene mRNA signatureMicroarray81Composite
tuberculosis 25719 for a diagnostic or triage testDhanasekaran S.[[58]]Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India2013Genes and ImmunityIndiaWhole
tuberculosis 26061 controlsNRNR0.92 (95%CI:NR)13107NAArmand M.[[59]]Cytokine responses to Quantiferon peptides in pediatric tuberculosis : A pilot study2014J InfectFrancePlasmaCytokines(IP-10; IL-2; IL-5; IL-13)Multiplex47Case definition
tuberculosis 26822 J.X.[[60]]Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients2015Genet Mol ResChinaPBMCsmicroRNA-31RT-PCR125Clinical diagnostic criteria for paediatric
tuberculosis 26945 patients2015Genet Mol ResChinaPBMCsmicroRNA-31RT-PCR125Clinical diagnostic criteria for paediatric tuberculosis , (Pan JH et al 2014)Healthy controls0.99 (95%CI:NR)0.87 (95%CI:NR)0.97 (95%CI: 0.93–0.99)6560Meets
tuberculosis 27237 for a diagnostic testLi Q.[[61]]Increased IL-9 mRNA expression as a biomarker to diagnose childhood tuberculosis in a high burden setting.2015J InfectChinaPBMCsIL-9 mRNAqPCR64Case definition not specifiedHealthy controls0.69
tuberculosis 28032 triage testZhou M.Y.[[63]]Circulating microRNAs as biomarkers for the early diagnosis of childhood tuberculosis infection2016Mol Med RepChinaPBMCsmicroRNA signature (μRNA-1, μR-10a, μRNA-31, μRNA-125b, μRNA-146a,

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