Electrocardiographic abnormalities in Chagas disease in the general population: A systematic review and meta-analysis.

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AIDS 1 infectiousdiseases
Chagas disease 45 infectiousdiseases

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AIDS 34665 in the United States and Canada. Eminent scientists have labeled Chagas Disease as ‘‘The New HIV/ AIDS of the Americas’’, and 20–30% of people infected with Chagas disease will develop potentially
Chagas disease 77 Title: PLoS Neglected Tropical DiseasesElectrocardiographic abnormalities in Chagas disease in the general population: A systematic review and meta-analysisAlternative Title: Electrocardiographic
Chagas disease 219 A systematic review and meta-analysisAlternative Title: Electrocardiographic (ECG) abnormalities in Chagas disease Lyda Z. Rojas (Conceptualization) (Formal analysis) (Funding acquisition) (Methodology) (Writing –
Chagas disease 2754 Hospital, ITALYPublication date (epub): 6/2018Publication date (collection): 6/2018AbstractBackground Chagas disease (CD) is a major public health concern in Latin America and a potentially serious emerging threat in
Chagas disease 5023 children was similar to that in adults and suggests earlier onset of cardiac disease.SummaryAuthor summary Chagas disease (CD) is a major public health concern in Latin America and a potentially serious emerging threat in
Chagas disease 5621 reviewed and meta-analyzed population-based studies that compared prevalence of ECG abnormalities between Chagas disease (CD) and non-CD participants. Forty-nine studies were selected, including 34,023 unique participants.
Chagas disease 6201 AvailabilityAll relevant data are within the paper and its Supporting Information files.Introduction Chagas disease (CD), is caused by the protozoan Trypanosoma cruzi[[1]]. It affects individuals from more than 21 countries,
Chagas disease 15645 1).10.1371/journal.pntd.0006567.g002Fig 2Meta-analyses of overall ECG abnormalities in Chagas and Non- Chagas disease .The box are proportional to the weight of each study in the analysis, and the lines represent their
Chagas disease 15901 diamond represents the pooled odds ratio, and its width represents it’s 95% CI. Abbreviations: CD= Chagas disease : CAs=ECG abnormalities.10.1371/journal.pntd.0006567.t001Table 1Meta-analysis of overall ECG abnormalities
Chagas disease 18796 heterogeneity was evaluated using random-effects meta-regression†Total positive and negative for Chagas disease ‡Adjusted by confounders as age, sex and others in designAbbreviations: CD=Chagas disease; CAs=ECG
Chagas disease 18887 negative for Chagas disease‡Adjusted by confounders as age, sex and others in designAbbreviations: CD= Chagas disease ; CAs=ECG abnormalities; OR=Odds ratio.Up to 30 studies (range 3 to 30), based on 3,451 ± 1,350 participants,
Chagas disease 21099 overall and specified ECG abnormalities with CD to compared Non-CD participants. Abbreviations: CD= Chagas disease ; RBBB=Right bundle branch block; LAFB=Left anterior fascicular block; AV-B=Atrioventricular block.10.1371/journal.pntd.0006567.t002Table
Chagas disease 22531 (0.82-1.59)2.80.4170.428OtherLow voltage QRS102,426453,149790.84 (0.47-1.50)28.60.1810.421Abbreviations: ECG=Electrocardiogram; CD= Chagas disease ; OR=Odds ratio; RBBB=Right bundle branch block; LBBB=Left bundle branch block; LAFB=Left anterior fascicular
Chagas disease 34730 Chagas Disease as ‘‘The New HIV/AIDS of the Americas’’, and 20–30% of people infected with Chagas disease will develop potentially fatal cardiomyopathy in their lifetime. Yet, there is no vaccine or highly
Chagas disease 35745 better detection, diagnosis, treatment and management of affected populations. Improved morbid-mortality Chagas disease estimates at population level will serve to highlight the real need for better detection, diagnostics,
Chagas disease 36682 file.S1 AppendixLiterature search for studies that investigated the prevalence of ECG abnormalities in Chagas disease .(DOCX)Click here for additional data file.S2 AppendixAssessments of study quality of the studies included
Chagas disease 37127 of the studies included in systematic review and meta-analysis of prevalence of ECG abnormalities in Chagas disease .(DOCX)Click here for additional data file.S2 TableDefinition of ECG abnormalities in each study included
Chagas disease 37946 test.(DOCX)Click here for additional data file.S8 TableDiscriminatory capacity of the ECG for the diagnosis of Chagas disease s.(DOCX)Click here for additional data file.S1 FigPooled odds ratios for the complete right bundle branch
Chagas disease 38083 additional data file.S1 FigPooled odds ratios for the complete right bundle branch block (CRBBB) in Chagas disease .(TIF)Click here for additional data file.S2 FigPooled odds ratios for the left anterior fascicular block
Chagas disease 38213 for additional data file.S2 FigPooled odds ratios for the left anterior fascicular block (LAFB) in Chagas disease .(TIF)Click here for additional data file.S3 FigPooled odds ratios for the combination complete right
Chagas disease 38402 combination complete right bundle branch block (CRBBB) and left anterior fascicular block (LAFB) in Chagas disease .(TIF)Click here for additional data file.S4 FigPooled odds ratios for the incomplete right bundle branch
Chagas disease 38539 additional data file.S4 FigPooled odds ratios for the incomplete right bundle branch block (IRBBB) in Chagas disease .(TIF)Click here for additional data file.S5 FigPooled odds ratios for the incomplete left bundle branch
Chagas disease 38675 additional data file.S5 FigPooled odds ratios for the incomplete left bundle branch block (ILBBB) in Chagas disease .(TIF)Click here for additional data file.S6 FigPooled odds ratios for the complete left bundle branch
Chagas disease 38809 additional data file.S6 FigPooled odds ratios for the complete left bundle branch block (CLBBB) in Chagas disease .(TIF)Click here for additional data file.S7 FigPooled odds ratios for the left posterior fascicular
Chagas disease 38940 for additional data file.S7 FigPooled odds ratios for the left posterior fascicular block (LPFB) in Chagas disease .(TIF)Click here for additional data file.S8 FigPooled odds ratios for the first degree left atrioventricular
Chagas disease 39081 additional data file.S8 FigPooled odds ratios for the first degree left atrioventricular block (A-V B) in Chagas disease .(TIF)Click here for additional data file.S9 FigPooled odds ratios for the second degree left atrioventricular
Chagas disease 39223 additional data file.S9 FigPooled odds ratios for the second degree left atrioventricular block (A-V B) in Chagas disease .(TIF)Click here for additional data file.S10 FigPooled odds ratios for the third degree left atrioventricular
Chagas disease 39365 additional data file.S10 FigPooled odds ratios for the third degree left atrioventricular block (A-V B) in Chagas disease .(TIF)Click here for additional data file.S11 FigPooled odds ratios for atrial fibrillation (AF) in Chagas
Chagas disease 39479 disease.(TIF)Click here for additional data file.S11 FigPooled odds ratios for atrial fibrillation (AF) in Chagas disease .(TIF)Click here for additional data file.S12 FigPooled odds ratios for supraventricular extrasystoles
Chagas disease 39604 here for additional data file.S12 FigPooled odds ratios for supraventricular extrasystoles (SE) in Chagas disease .(TIF)Click here for additional data file.S13 FigPooled odds ratios for atrial fibrillation (AF) or flutter
Chagas disease 39729 here for additional data file.S13 FigPooled odds ratios for atrial fibrillation (AF) or flutter in Chagas disease .(TIF)Click here for additional data file.S14 FigPooled odds ratios for ventricular extrasystoles (VE)
Chagas disease 39849 disease.(TIF)Click here for additional data file.S14 FigPooled odds ratios for ventricular extrasystoles (VE) in Chagas disease .(TIF)Click here for additional data file.S15 FigPooled odds ratios for low voltage QRS (LV-QRS) in Chagas
Chagas disease 39963 disease.(TIF)Click here for additional data file.S15 FigPooled odds ratios for low voltage QRS (LV-QRS) in Chagas disease .(TIF)Click here for additional data file.S16 FigPooled odds ratios for the prevalence of ECG abnormalities
Chagas disease 40088 here for additional data file.S16 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by assessments of study quality.(TIF)Click here for additional data file.S17 FigPooled odds ratios for
Chagas disease 40245 here for additional data file.S17 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by period of publication.(TIF)Click here for additional data file.S18 FigPooled odds ratios for the
Chagas disease 40395 here for additional data file.S18 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by location.(TIF)Click here for additional data file.S19 FigPooled odds ratios for the prevalence of
Chagas disease 40532 here for additional data file.S19 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by design.(TIF)Click here for additional data file.S20 FigPooled odds ratios for the prevalence of ECG
Chagas disease 40667 here for additional data file.S20 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by area.(TIF)Click here for additional data file.S21 FigPooled odds ratios for the prevalence of ECG
Chagas disease 40800 here for additional data file.S21 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by area (Rural vs Urban).(TIF)Click here for additional data file.S22 FigPooled odds ratios for the
Chagas disease 40950 here for additional data file.S22 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by test for the diagnoses.(TIF)Click here for additional data file.S23 FigPooled odds ratios for the
Chagas disease 41101 here for additional data file.S23 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by confounders adjustment.(TIF)Click here for additional data file.S24 FigPooled odds ratios for the
Chagas disease 41249 adjustment.(TIF)Click here for additional data file.S24 FigPooled odds ratios for the prevalence of ECG abnormalities Chagas disease by number of participants.(TIF)Click here for additional data file.S25 FigPooled odds ratios for the
Chagas disease 41397 participants.(TIF)Click here for additional data file.S25 FigPooled odds ratios for the prevalence of ECG abnormalities Chagas disease by age of participants.(TIF)Click here for additional data file.S26 FigPooled odds ratios for the prevalence
Chagas disease 41542 participants.(TIF)Click here for additional data file.S26 FigPooled odds ratios for the prevalence of ECG abnormalities Chagas disease by sex of participants.(TIF)Click here for additional data file.S27 FigPooled odds ratios for the prevalence
Chagas disease 41690 here for additional data file.S27 FigPooled odds ratios for the prevalence of ECG abnormalities in Chagas disease by definition of ECG abnormalities.(TIF)Click here for additional data file.S28 FigMeta-analysis estimates
Chagas disease 41977 omitted.(TIF)Click here for additional data file.S29 FigPooled odds ratios for the prevalence of ECG abnormalities Chagas disease by age of participants (exclude Aguilera M et al. 1996).(TIF)Click here for additional data file.S30

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