The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

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Term Occurence Count Dictionary
cowpox 1 infectiousdiseases
hepatitis B 1 infectiousdiseases
hepatitis C 4 infectiousdiseases
herpes simplex 2 infectiousdiseases
rubella 2 infectiousdiseases
vaccinia 2 infectiousdiseases
hepatitis E 1 infectiousdiseases
Rift Valley fever 1 infectiousdiseases
chloroquine 2 infectiousdiseasesdrugs
Japanese encephalitis 1 infectiousdiseases
Venezuelan equine encephalitis 1 infectiousdiseases
chikungunya 1 infectiousdiseases
hepatitis A 1 infectiousdiseases
mumps 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
chloroquine 5972 mechanistic data of these compounds, as well as efficacy studies in mouse models, are lacking. Ribavirin and chloroquine are the only two drugs that have been tested in clinical trials [[40]]. Despite having promising in
chloroquine 6096 two drugs that have been tested in clinical trials [[40]]. Despite having promising in vitro data, chloroquine was found to be ineffective in clinical trials [[41],[42]]. On the other hand, Ribavirin was found to
Select Disease Character Offset Disease Term Instance
Japanese encephalitis 64321 is proposed to stabilize CHIKV nsP2 during infection.Hsp90β:Proposed to be the binding receptor for Japanese encephalitis virus (JEV).Proposed to facilitate assembly of enterovirus 71 viral particles.Hepatitis B virus polymerase
Rift Valley fever 56060 virus, Machupo virus MACV) Nipah virus, Zaire ebolavirus (ZEBOV), Lake Victoria marburgvirus (MARV), Rift Valley fever virus (RVFV), cowpox virus (CPXV), and influenza virus.[[142],[143],[237],[238],[239],[240],[241],[242],[243],[244]]nsP1BST-2BST-2:See
Venezuelan equine encephalitis 31028 (~471–791 aa) (PDB code 3TRK (2011) and 4ZTB (2016)) and that of alphavirus relatives, SINV, and Venezuelan equine encephalitis virus (VEEV) are available for comparison [[157],[158],[159]]. The domains in the N terminal region,
chikungunya 1645 host environment and CHIKV in order to generate potential therapeutics.1. IntroductionIn recent years, chikungunya virus (CHIKV) has re-emerged as one of the many arthropod-borne viruses (arboviruses) that can pose
cowpox 56092 virus, Zaire ebolavirus (ZEBOV), Lake Victoria marburgvirus (MARV), Rift Valley fever virus (RVFV), cowpox virus (CPXV), and influenza virus.[[142],[143],[237],[238],[239],[240],[241],[242],[243],[244]]nsP1BST-2BST-2:See
hepatitis A 53049 cell—proliferation.hTIM1:Possible attachment/entry factor.hTIM1:Implicated as receptors for non-enveloped hepatitis A virus and enveloped viruses such as Zaire Ebolavirus and Lake Victoria Marburgvirus.[[129],[226],[227],[228]]AXL
hepatitis B 52618 (examples cell signaling, etc.).GAGs:Possible attachment/entry factor.GAGs:Allows binding and infection of hepatitis B virus.Attachment factor for respiratory syncytial virus (RSV), coronavirus NL63 (CoV-NL63), and the
hepatitis C 51350 first characterized receptor protein for dengue virus in insect cells.Proposed to be entry factors for hepatitis C virus.[[124],[215],[216],[217]]PTPN2PTPN2:A tyrosine phosphatase that dephosphorylates protein tyrosine
hepatitis C 54227 properties. Also suggested to play a role in ER stress response.THBS1:Mechanism unknown.THBS1:Induced by hepatitis C virus (HCV) to promote the proteolytic activation TGF-β1, which promotes HCV RNA replication.[[128],[234]]DYNC1H1DYNC1H1:Subunit
hepatitis C 55838 release.Restricts viral like particle (VLP) release of the following viruses: vesicular stomatitis virus (VSV), hepatitis C virus (HCV), Kaposi’s sarcoma-associated herpesvirus (KSHV), human immunodeficiency virus 1 (HIV-1),
hepatitis C 58842 virus titer.MRFAP1L1:Not reported.EWSR1:Binds directly with the cis-acting replication element (CRE) of hepatitis C virus. Depletion of EWSR1 impairs HCV viral replication and reduced virus titers without affecting translation.IKZF1:Not
hepatitis E 37148 found in all living organisms including positive sense RNA viruses like alphaviruses, coronaviruses, hepatitis E virus and rubella virus [[179]]. The macro domain is believed to function mainly as an ADP hydrolase
herpes simplex 54879 transport of influenza virus X-31, human foamy virus (HFV), HIV1 reverse transcription complexes (RTC), herpes simplex virus type 1, and Mokola virus.[[128],[235],[236]]ATP1B3ATP1B3:Part of the sodium/potassium-transporting
herpes simplex 58649 unknown.ASCC2:Not reported.TRIM27:Interacts and is degraded by the immediate early protein ICP0 of the herpes simplex virus 1 (HSV-1). However, depletion of TRIM27 in cells results in reduced virus titer.MRFAP1L1:Not reported.EWSR1:Binds
mumps 60536 ubiquitination of the matrix proteins.UBQLN4:Shown to interact with small hydrophobic (SH) protein of mumps virus and relocate them to 20S proteasome, possibly for proteosomal degradation.[[175],[255],[256],[257]]PDK2
rubella 27087 specifically block the exit of alphaviruses (e.g., SFV and CHIKV) efficiently [[143]]. In addition, although rubella virus and dengue virus share similar virion structure as the alphaviruses, they responded differently
rubella 37170 organisms including positive sense RNA viruses like alphaviruses, coronaviruses, hepatitis E virus and rubella virus [[179]]. The macro domain is believed to function mainly as an ADP hydrolase that removes mono
vaccinia 22564 CHIKV, similar to other enveloped viruses, including Pichinde virus, vesicular stomatitis virus, and vaccinia virus [[130],[131]]. By taking advantage of the exposed PS, the CHIKV is able to enter the cells. However,
vaccinia 53452 attachment/entry factor.AXL:Implicated as receptors for Ebolavirus, Marburgvirus, pseudo-typed lentiviral, vaccinia virus, and Lassa virus.[[129],[229],[230],[231]]6K/TF-----E1COMMD1COMMD1:A proposed scaffold protein

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