Phage-Derived Peptidoglycan Degrading Enzymes: Challenges and Future Prospects for In Vivo Therapy

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Term Occurence Count Dictionary
gentamicin 1 infectiousdiseasesdrugs
infectious disease 1 infectiousdiseases
pneumonia 4 infectiousdiseases
vancomycin 1 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
gentamicin 12584 [[48]]. Synergistic effects have also been demonstrated with the Cpl-1 endolysin and penicillin or gentamicin antibiotics against S. pneumoniae strains with different levels of susceptibilities to penicillin [[49]].
vancomycin 12123 and multidrug-resistant S. aureus (endolysins LysK and MV-L, respectively) [[45],[46]], and towards vancomycin -resistant E. faecalis and E. faecium (endolysin PlyV12) [[47]]. Endolysins have also been used in cocktails
Select Disease Character Offset Disease Term Instance
infectious disease 3554 useful when aiming at using the antibacterial potential of these enzymes (“enzybiotics”) against infectious disease s in vitro and in vivo.2. Peptidoglycan-Degrading Enzymes—An Emerging Class of Antibacterial Agents2.1.
pneumonia 2384 millennium [[3],[4],[5]].ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia e, Acinetobacter baumannii, Pseudomonas aeruginosa and other Enterobacteriaceae species) are the leading
pneumonia 12335 cocktails or in combination with antibiotics to eliminate pathogenic bacteria. Antibiotic-resistant S. pneumonia e strains have been targeted using Cpl-1 and Pal endolysins, which share the same target specificity
pneumonia 12618 also been demonstrated with the Cpl-1 endolysin and penicillin or gentamicin antibiotics against S. pneumonia e strains with different levels of susceptibilities to penicillin [[49]]. Moreover, the need to develop
pneumonia 13124 the most part pioneered by studies that highlighted the modular character of the lytic enzymes of S. pneumonia e and its phages. It was shown that ECDs and CBDs from different enzymes could be exchanged to generate

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