Calcium Ion Channels: Roles in Infection and Sepsis Mechanisms of Calcium Channel Blocker Benefits in Immunocompromised Patients at Risk for Infection

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
sulfadiazine 1 infectiousdiseasesdrugs
tuberculosis 12 infectiousdiseases
abscess 2 infectiousdiseases
ethambutol 1 infectiousdiseasesdrugs
pertussis 2 infectiousdiseases
quinine 2 infectiousdiseasesdrugs
hepatitis B 2 infectiousdiseases
malaria 2 infectiousdiseases
cerebral malaria 1 infectiousdiseases
eflornithine 2 infectiousdiseasesdrugs
epinephrine 2 infectiousdiseasesdrugs
pulmonary tuberculosis 1 infectiousdiseases
septic shock 3 infectiousdiseases
sulfamethoxazole 1 infectiousdiseasesdrugs
Plasmodium falciparum malaria 1 infectiousdiseases
infectious disease 1 infectiousdiseases
pneumonia 7 infectiousdiseases
praziquantel 2 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
eflornithine 21107 Schistosoma mansoni infestation [[52],[53]], amphotericin-resistant Leishmania donovani [[54]], and eflornithine -resistant Trypanosoma cruzi [[55]]. Benidipine may be useful for treatment of Toxoplasma gondii infestation
eflornithine 45730 mycobacteriumc.quinine-resistant plasmodiumd.praziquantel-resistant schistosomee.amphotericin-resistant leishmaniaf. eflornithine -resistant trypanosomeII. Role of calcium movement in white blood cell defense against pathogensNeutrophils
epinephrine 7915 renal proximal tubules. Since calcitriol has been shown to be additive to the inotropic effects of nor epinephrine and vasopressin [[21]] and since receptors for 1,25(OH)2 D are found in increased amounts in hypertrophied
epinephrine 36652 might be highly effective. In addition, flunarizine has been shown to inhibit vasoconstriction by nor epinephrine and to diminish the risk of small vessel thrombosis [[86]]. Angiotensin caused vasoconstriction can
ethambutol 22710 found in experimental cerebral malaria [[54]]. Resistance to rifampicin and other antibiotics like ethambutol is a major impediment to recovery from pulmonary tuberculosis for individuals who are immune-suppressed
praziquantel 20984 rifampicin-resistant tuberculosis [[49]], quinine-resistant Plasmodium falciparum malaria [[50],[51]], and praziquantel -resistant Schistosoma mansoni infestation [[52],[53]], amphotericin-resistant Leishmania donovani [[54]],
praziquantel 45659 dosesa.quinolone-resistant streptococcusb.rifampicin-resistant mycobacteriumc.quinine-resistant plasmodiumd. praziquantel -resistant schistosomee.amphotericin-resistant leishmaniaf.eflornithine-resistant trypanosomeII. Role
quinine 20919 studied in quinolone-resistant pneumococcal pneumonia [[48]], rifampicin-resistant tuberculosis [[49]], quinine -resistant Plasmodium falciparum malaria [[50],[51]], and praziquantel-resistant Schistosoma mansoni
quinine 45629 side effects of higher dosesa.quinolone-resistant streptococcusb.rifampicin-resistant mycobacteriumc. quinine -resistant plasmodiumd.praziquantel-resistant schistosomee.amphotericin-resistant leishmaniaf.eflornithine-resistant
sulfadiazine 21274 useful for treatment of Toxoplasma gondii infestation for individuals allergic to sulfonamides like sulfadiazine or sulfamethoxazole [[56]].Pathogens able to efficiently extrude antibiotics quickly become resistant
sulfamethoxazole 21290 treatment of Toxoplasma gondii infestation for individuals allergic to sulfonamides like sulfadiazine or sulfamethoxazole [[56]].Pathogens able to efficiently extrude antibiotics quickly become resistant since they are being
Select Disease Character Offset Disease Term Instance
Plasmodium falciparum malaria 20937 quinolone-resistant pneumococcal pneumonia [[48]], rifampicin-resistant tuberculosis [[49]], quinine-resistant Plasmodium falciparum malaria [[50],[51]], and praziquantel-resistant Schistosoma mansoni infestation [[52],[53]], amphotericin-resistant
abscess 12282 availability of clean needles did not protect diabetic dialysis patients from life-threatening cellulitis, abscess formation, and sepsis [[33]] All the instances of visceral infection occurred in the setting of cocaine
abscess 24243 bacteria are Bacillus, Clostridium, Listeria, Mycobacterium, Staphylococcus. A rare Mycobacterium, M. abscess us is an important pathogen in cystic fibrosis, an inherited disorder with an increased risk of pneumonia
cerebral malaria 22633 infusion has been found effective in normalizing the electrocardiographic changes found in experimental cerebral malaria [[54]]. Resistance to rifampicin and other antibiotics like ethambutol is a major impediment to recovery
hepatitis B 28999 the cytosol through the plasma membrane. Studies of defense mechanisms in liver cells infected with hepatitis B virus identify SOCE as being therapeutic for a short period of time. SOCE mechanisms may be activated
hepatitis B 29206 activated during times of cytogenetic, inflammatory and hemodynamic instability.In the instance of the hepatitis B patient or the victim of an attack by poliovirus [[77]], calcium transfer most likely occurred in the
infectious disease 43559 further observations suggesting that this inexpensive class of medications might enhance treatment of infectious disease s should direct future trials. Another untested possibility is the hypothesis that use of statins to
malaria 20959 pneumonia [[48]], rifampicin-resistant tuberculosis [[49]], quinine-resistant Plasmodium falciparum malaria [[50],[51]], and praziquantel-resistant Schistosoma mansoni infestation [[52],[53]], amphotericin-resistant
malaria 22642 been found effective in normalizing the electrocardiographic changes found in experimental cerebral malaria [[54]]. Resistance to rifampicin and other antibiotics like ethambutol is a major impediment to recovery
pertussis 25630 Catalase may be responsible for survival of antibiotic-resistant P. aeruginosa [[68]], but for Bordetella pertussis , dismutase is more important than catalase for survival within polymorphonuclear leukocytes [[69]].
pertussis 46544 mechanisms may or may not involve calciumGeneration of anti-oxidants (catalase, dismutase) Bortadella pertussis Pseudomonas aeruginosaEfflux of calcium from host cells Bacillus anthracisClostridium perfringensStreptococcus
pneumonia 3529 channel blockers [[1]]. One retrospective cohort study revealed that when 387 patients hospitalized for pneumonia who had not been treated with calcium channel blockers, were compared to 387 similarly hospitalized
pneumonia 3653 been treated with calcium channel blockers, were compared to 387 similarly hospitalized patients with pneumonia who had received calcium channel blockers there was a significantly higher incidence of bacteremia,
pneumonia 20859 efficiency goal (Table 2). Calcium channel blockers have been studied in quinolone-resistant pneumococcal pneumonia [[48]], rifampicin-resistant tuberculosis [[49]], quinine-resistant Plasmodium falciparum malaria [[50],[51]],
pneumonia 24346 abscessus is an important pathogen in cystic fibrosis, an inherited disorder with an increased risk of pneumonia associated with airway obstruction. Although this pathogen is fast-growing, it is frequently antibiotic-resistant
pneumonia 25993 which mechanism has been observed in Bacillus anthracis, Clostridium perfringens, and Streptococcus pneumonia e (Table 2). It would appear the first of these mechanisms would be of relatively short-term benefit
pneumonia 37355 for protection is an obvious area of sepsis study since lack of vitamin D is associated with risk of pneumonia [[87],[88]]. In this connection relevant roles of vitamin D consist of assisting parathyroid hormone
pneumonia 46664 aeruginosaEfflux of calcium from host cells Bacillus anthracisClostridium perfringensStreptococcus pneumonia eColony growth mechanisms inhibited by calcium channel blockersAspergillus fumigatusSaccharomyces cerevisiaeCandida
pulmonary tuberculosis 22760 Resistance to rifampicin and other antibiotics like ethambutol is a major impediment to recovery from pulmonary tuberculosis for individuals who are immune-suppressed by malnutrition, uncontrolled glycemia, uremia, cancer chemotherapy.
septic shock 4869 involving ligation of the cecum with puncture of the wall of the intestine was one such example. This septic shock model was used to [[4]] demonstrate a lesser accumulation of oxygen radicals [[5]] as well as longer
septic shock 5041 of oxygen radicals [[5]] as well as longer survival if diltiazem were injected prior to the onset of septic shock .2.1. Positive ResultsSeveral studies have addressed the use of dihydropyridine and non-dihydropyridine
septic shock 32888 model has demonstrated relatively longer survival if diltiazem were injected prior to the onset of septic shock [[4]] in association with decreased formation of oxygen radicals [[5]]. Specific mechanisms for protection
tuberculosis 20898 blockers have been studied in quinolone-resistant pneumococcal pneumonia [[48]], rifampicin-resistant tuberculosis [[49]], quinine-resistant Plasmodium falciparum malaria [[50],[51]], and praziquantel-resistant Schistosoma
tuberculosis 21575 have been useful through closing the channel through which antibiotics are extruded. Mycobacterium tuberculosis has the capacity to extrude antibiotics which have entered through its tough outer membrane. The efflux
tuberculosis 22770 to rifampicin and other antibiotics like ethambutol is a major impediment to recovery from pulmonary tuberculosis for individuals who are immune-suppressed by malnutrition, uncontrolled glycemia, uremia, cancer chemotherapy.
tuberculosis 23285 blocker.Two biologic defensive mechanisms are responsible for the antibiotic resistance of Mycobacterium tuberculosis and M. smegmatis. The first is the antibiotic efflux process which has now been demonstrated on the
tuberculosis 24538 frequently antibiotic-resistant [[65]]. Data on calcium channel blocker impact in this rare form of tuberculosis may be forth-coming from current studies, particularly in India. It is now known that antibiotic-resistant
tuberculosis 24661 forth-coming from current studies, particularly in India. It is now known that antibiotic-resistant M. tuberculosis not only works by extrusion of antibiotics, but also by preventing their entry in the first place.3.2.
tuberculosis 33844 recent reports of protection from sepsis have emerged from studies of antibiotic-resistant Myocobacteria tuberculosis . Along these lines, one analog of a calcium channel blocker (verapamil) may be more effective than another
tuberculosis 34010 blocker (verapamil) may be more effective than another in assisting rifampicin in its battle with M. tuberculosis for reasons not easily understood in terms of L-type calcium channels, but rather by efficiency of docking
tuberculosis 34396 infection. Newer analogs however may become available [[83]]. It is now known that antibiotic-resistant M. tuberculosis bacilli inhibit entry and accelerate extrusion of antibiotics. Control of cytosolic calcium entry or
tuberculosis 38367 these agents are found in bronchopulmonary sites under attack from pathogens, such as Mycobacterium tuberculosis , they can be expected to offer a measure of protection in the lung.Genes are being identified which
tuberculosis 38645 receptors (called Toll-like) which assist in generation of cathelicidins [[25]]. Susceptibility to tuberculosis is associated with vitamin D deficiency as well as a lack of production of cathelicidins. Efficiently
tuberculosis 39033 the Vitamin D receptor is the peptide, cathelicidin, with bactericidal capacity against Mycobacterium tuberculosis (Table 2). This suggests that hydroxylation of the cholecalciferol by the 1-alpha hydroxylase activates

You must be authorized to submit a review.