Enterococcus gallinarum meningitis: a case report and literature review.

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Annotation Summary

Term Occurence Count Dictionary
ampicillin 5 infectiousdiseasesdrugs
ceftriaxone 1 infectiousdiseasesdrugs
gentamicin 1 infectiousdiseasesdrugs
meningitis 6 infectiousdiseases
meropenem 1 infectiousdiseasesdrugs
vancomycin 2 infectiousdiseasesdrugs
ofloxacin 2 infectiousdiseasesdrugs
septic shock 1 infectiousdiseases
tuberculosis 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
ampicillin 10158 removalCuredYoko Takayama. et al. [[8]] 2003JapanMale12 yearsFeverDrowsyLimb crampsVP shunt for astrocytomai.v. ampicillin for 8 weeksVP shunt replacedCuredAsok Kurup, et al. [[9]] 2001SingaporeMale64 yearsFeverDrowsyVP shunt
ampicillin 10312 Kurup, et al. [[9]] 2001SingaporeMale64 yearsFeverDrowsyVP shunt for multi-loculated hydrocephalusi.v. ampicillin and gentamicin for 3 weeksCuredFahmi Yousef Khan, et al. [[10]] 2011PakistanFemale53 yearsFeverHeadacheConsciousness
ampicillin 10668 Antonello, et al. [[11]] 2010BrazilMale53 yearsMental confusionFeverAtaxiaNeck stiffnessAlcohol abusei.v. ampicillin and gentamycin for 3 weeksCuredB. Roca, et al. [[12]] 2006SpainFemale51 yearsFeverHeadacheCerebrospinal
ampicillin 10853 2006SpainFemale51 yearsFeverHeadacheCerebrospinal fluid drainage catheter for persistent right nostril rhinorrheai.v. ampicillin and rifampin for 3 weeksDrain removalCuredPo-Yi Paul Su, et al. [[5]] 2016USAMale53 yearsFeverNeck
ampicillin 11099 cell leukemia with chemotherapyNeutropenicBroad-spectrum antibiotics usageType 2 diabetes mellitusi.v. ampicillin and ceftriaxone for 4 weeksCuredQuanxiao Li, et al. [[13]] 2013ChinaMale2 daysFeverHypermyotoniaNeonatal
ceftriaxone 11114 chemotherapyNeutropenicBroad-spectrum antibiotics usageType 2 diabetes mellitusi.v. ampicillin and ceftriaxone for 4 weeksCuredQuanxiao Li, et al. [[13]] 2013ChinaMale2 daysFeverHypermyotoniaNeonatal hemolysisi.v.
gentamicin 10327 2001SingaporeMale64 yearsFeverDrowsyVP shunt for multi-loculated hydrocephalusi.v. ampicillin and gentamicin for 3 weeksCuredFahmi Yousef Khan, et al. [[10]] 2011PakistanFemale53 yearsFeverHeadacheConsciousness
meropenem 1792 20.55 × 109/L; C reactive protein (CRP): 136.4 mg/L; procalcitonin, 6.70 ng/mL. The patient was given meropenem (2.0 g, intravenous infusion, every 8 h) for anti-infection supplemented with other symptomatic support
ofloxacin 6736 GMIC8.0S≥16≤8VancomycinMIC2.0R≥328–16≤4LinezolidMIC1.0S≥84≤2TetracyclineMIC≥16.0R≥168≤4Cipr ofloxacin MIC≤0.5S≥42≤1ErythromycinMIC8.0R≥81–4≤0.5LevofloxacinMIC1.0S≥84≤2AmpicllinMIC≤2.0S≥16≤8Quinupristin/DalfopristinMIC1.0R≥42≤1ClindamycinMIC≥8.0R≥41–2≤0.5MoxifloxacinMIC≤0.25S≥42≤1TigecyclineMIC≤0.12S≤0.25Gentamicin-HighMICSStreptomycin-HighMICRMIC
ofloxacin 6801 GMIC8.0S≥16≤8VancomycinMIC2.0R≥328–16≤4LinezolidMIC1.0S≥84≤2TetracyclineMIC≥16.0R≥168≤4CiprofloxacinMIC≤0.5S≥42≤1ErythromycinMIC8.0R≥81–4≤0.5Lev ofloxacin MIC1.0S≥84≤2AmpicllinMIC≤2.0S≥16≤8Quinupristin/DalfopristinMIC1.0R≥42≤1ClindamycinMIC≥8.0R≥41–2≤0.5MoxifloxacinMIC≤0.25S≥42≤1TigecyclineMIC≤0.12S≤0.25Gentamicin-HighMICSStreptomycin-HighMICRMIC
vancomycin 11410 intravenousEnterococcus gallinarum carries the vanC drug-resistance gene and has a high rate of resistance for vancomycin (82.1%). The pathogen is relatively sensitive to teicoplanin and linezolid [[2]]. The strains carrying
vancomycin 11599 [[2]]. The strains carrying the vanA or vanB resistance genes have been isolated, and are resistant to vancomycin and teicoplanin.[[7]]. Based on drug sensitivity testing, we chose linezolid at an adequate dose and
Select Disease Character Offset Disease Term Instance
meningitis 54 Title: BMC Infectious DiseasesEnterococcus gallinarum meningitis : a case report and literature reviewBo ZhaoMao Sheng YeRui ZhengPublication date (epub): 5/2018Publication
meningitis 8078 caused by E. gallinarum are rare, but have been reported more often in recent years.Symptoms of E. meningitis include fevers and headaches, which may be accompanied by a disturbance of consciousness or even convulsions.
meningitis 8393 meningeal irritation [[4]]. High value of CRP and procalcitonin can be found in patients with E. gallinarum meningitis . The diagnosis of E. gallinarum meningitis is based on clinical symptoms, cerebrospinal fluid examination,
meningitis 8436 procalcitonin can be found in patients with E. gallinarum meningitis. The diagnosis of E. gallinarum meningitis is based on clinical symptoms, cerebrospinal fluid examination, and pathogen culture. PCR is also used
meningitis 9353 of broad-spectrum antibiotics may have exacerbated the infection.There have been eight E. gallinarum meningitis cases reported worldwide (Table 3). The previous cases were generally secondary to neurosurgery, especially
meningitis 9732 risk factors (immune impairment and an invasive surgical procedure).Table 3Enterococcus gallinarum meningitis reports in the literatureReferenceCountryGenderAgeSymptomsSusceptibility factorsTreatmentOutcomeYoko
septic shock 8222 which may be accompanied by a disturbance of consciousness or even convulsions. Some patients may have septic shock , focal neurologic deficits, petechial rashes, and meningeal irritation [[4]]. High value of CRP and
tuberculosis 6235 (120–132)121.5115120.0118.2119.7Protein g/L (0.15–0.45)1.080.840.520.410.33Cryptococcus smear (Ink stain)–––––Mycobacterium tuberculosis smear (Acid-fast stain)–––––Bacterial smear (Gram’s stain)–––––Bacterial culture

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