Heartland Virus Epidemiology, Vector Association, and Disease Potential

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Annotation Summary

Term Occurence Count Dictionary
diarrhea 1 infectiousdiseases
doxycycline 3 infectiousdiseasesdrugs
ehrlichiosis 3 infectiousdiseases
infectious disease 1 infectiousdiseases
meningitis 1 infectiousdiseases
ribavirin 1 infectiousdiseasesdrugs
Rift Valley fever 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
doxycycline 3190 enzymes (transaminases), during hospitalization. Given the concern for ehrlichiosis, both received doxycycline ; however, no significant improvement was noted. Although each sample did reveal cytopathic effects in
doxycycline 15435 ranges. Clinical improvement within 48–72 h of starting appropriate antibiotics for ehrlichiosis (i.e., doxycycline ) versus no substantial improvement of signs and symptoms after starting doxycycline could potentially
doxycycline 15519 ehrlichiosis (i.e., doxycycline) versus no substantial improvement of signs and symptoms after starting doxycycline could potentially be used to differentiate the most likely etiology.2.5. Clinical ManagementThere are
ribavirin 15974 support, vasopressors, blood products, or dialysis. For the SFTS virus, a number of therapeutics (e.g., ribavirin , steroids) were administered in attempts to lower disease morbidity and mortality, but none were found
Select Disease Character Offset Disease Term Instance
Rift Valley fever 39140 Accession numbers: Uukuniemi virus D10759; Precarious Point virus HM566181; Toscana virus FJ153281; Rift Valley fever virus JQ068144; Punta Toro virus KR912212; Lone Star virus NC 021242; Palma virus JQ956379; Bhanja virus
diarrhea 2901 and signs for the patients were similar and consisted of fever, fatigue, anorexia (loss of appetite), diarrhea , leukopenia (low white-blood-cell count), and thrombocytopenia (low platelet count). Both patients developed
ehrlichiosis 3162 as moderately elevated liver enzymes (transaminases), during hospitalization. Given the concern for ehrlichiosis , both received doxycycline; however, no significant improvement was noted. Although each sample did
ehrlichiosis 15223 signs of leukopenia and thrombocytopenia, seen with HRTV disease are very similar to those seen with ehrlichiosis , and they cannot be used to distinguish these two diseases which have overlapping geographic ranges.
ehrlichiosis 15415 overlapping geographic ranges. Clinical improvement within 48–72 h of starting appropriate antibiotics for ehrlichiosis (i.e., doxycycline) versus no substantial improvement of signs and symptoms after starting doxycycline
infectious disease 8835 Individuals with known non-infectious etiologies (e.g., cancer or chemotherapy) or diagnosed with another infectious disease that may result in these clinical findings were excluded. The inclusion criteria were selected after
meningitis 12454 WBC count of <5/µL), which would be seen with an infection of the brain (encephalitis) or meninges ( meningitis ).All individuals with acute HRTV disease had thrombocytopenia at presentation; nine also had leukopenia.

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