Hepatitis B virus infection: Defective surface antigen expression and pathogenesis

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Term Occurence Count Dictionary
famciclovir 1 infectiousdiseasesdrugs
hepatitis B 14 infectiousdiseases
hepatitis C 1 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
famciclovir 12638 antiviral therapy based on nucleotide analogs[[74]]. Treatment with first-generation drugs, such as famciclovir and adeforvir, resulted in the emergence of drug-resistant HBV mutants, with aa substitutions within
Select Disease Character Offset Disease Term Instance
hepatitis B 1867 of defective HBV surface antigen mutations and their contribution to the pathogenesis of fulminant hepatitis B . The relationship between defective surface antigens and occult HBV infection are also discussed.Core
hepatitis B 2193 publications have explored the association of defective surface antigen mutation with the development of hepatitis B virus (HBV)-associated hepatocellular carcinoma. However, there are no reviews available that elaborate
hepatitis B 2435 between defective surface antigen mutation and HBV-associated fulminant hepatitis (FH), as well as occult hepatitis B virus infection (OBI). This review will focus on these two aspects to discuss the nature of defective
hepatitis B 2909 worldwide[[1]]. Recent data obtained from a modeling study has shown that the global prevalence of hepatitis B surface antigen (HBsAg) was 3.9% in 2016, corresponding to an estimated 290 million infections worldwide[[2]].
hepatitis B 6286 is also regulated by the preS1 domain[[11]] (Figure 1).Figure 1The transcription and expression of hepatitis B virus surface proteins. The three HBV surface proteins, LHBs, MHBs, and SHBs, are translated from two
hepatitis B 15239 SURFACE ANTIGEN MUTATIONS AND THE HOSTDefective surface antigen mutations have been found in acute hepatitis B infection, chronic hepatitis B infection, and occult HBV infection and are associated with advanced
hepatitis B 15270 THE HOSTDefective surface antigen mutations have been found in acute hepatitis B infection, chronic hepatitis B infection, and occult HBV infection and are associated with advanced liver disease, including liver
hepatitis B 15403 HBV infection and are associated with advanced liver disease, including liver cirrhosis, fulminant hepatitis B , and HCC[[15],[82],[92]-[105]]. It has been questioned whether HBV mutants arise due to viral adaptation
hepatitis B 15872 emphasize in our discussion the relationship between defective surface antigen mutations and fulminant hepatitis B , as well as occult HBV infection.Defective surface antigen expression and fulminant hepatitisThere is
hepatitis B 16846 preS regions from HBV strains isolated from a patient with HBV-associated FH[[84]]. In addition, a hepatitis B immune globulin (HBIG)-escape mutant sG145R on the HBsAg, causing 30% inhibition of virion secretion,
hepatitis B 20706 co-infection[[137]] (Figure 2).Figure 2The proposed pathogenic role of mutated secretion-defective hepatitis B surface antigen in fulminant hepatitis. Defective surface antigens, such as preS deletions and mutations
hepatitis B 21678 fulminant hepatitis. HBsAg: Hepatitis B surface antigen.Defective surface antigen expression and occult hepatitis B virus infectionOccult HBV infection (OBI) is characterized by the presence of very low levels of HBV
hepatitis B 24964 (Figure 3).Figure 3The relationship between the expression of defective surface antigens and occult hepatitis B virus infection. Surface antigen mutations, such as preS deletions, can impair the transcription of
hepatitis B 25625 detected by immunoassays based on monoclonal antibodies, contributing to some cases of OBI. OBI: Occult hepatitis B virus infection; HBsAg: Hepatitis B surface antigen.PERSPECTIVESDefective surface antigen expression
hepatitis C 22432 immunosuppressive therapy, and after transplantation as well as in patients co-infected with HIV or hepatitis C virus (HCV)[[45],[146],[147]], which can result in the development of fulminant hepatitis and death[[139],[148]-[153]].Defective

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