Alternative strategies for mosquito-borne arbovirus control

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
chikungunya 4 infectiousdiseases
dengue fever 1 infectiousdiseases
malaria 6 infectiousdiseases
permethrin 6 infectiousdiseasesdrugs
yellow fever 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
permethrin 22619 [[55]].Currently, an ITM strategy for vector control is in Stage 1 of VCAG evaluations (Fig 1), with permethrin (a pyrethroid) being the only active ingredient used in ITMs due to requirements of meeting human safety
permethrin 23107 [[57],[58]], and an 80% reduction in A. aegypti densities after just one month of children wearing permethrin treated school uniforms [[59]]. Models have estimated permethrin-treated uniforms could reduce dengue
permethrin 23172 just one month of children wearing permethrin treated school uniforms [[59]]. Models have estimated permethrin -treated uniforms could reduce dengue infections by up to 55% in the most optimistic scenarios [[60]].Despite
permethrin 23436 vectors, current application techniques and formulations have limited efficacy under general use as permethrin washes out of material after several washes and is degraded by UV and heat exposure [[56],[61]]. Novel
permethrin 23620 heat exposure [[56],[61]]. Novel formulations are needed to achieve long-lasting, effective release of permethrin under anticipated use. A technology being developed to address this challenge is microencapsulation,
permethrin 23959 of the active ingredient [[62]]. Novel active ingredients that have far-ranging efficacy compared to permethrin and/or represent a different chemical class (including natural ingredients) will be needed to overcome
Select Disease Character Offset Disease Term Instance
chikungunya 2181 1/2019Publication date (collection): 1/2019AbstractBackgroundMosquito-borne viruses—such as Zika, chikungunya , dengue fever, and yellow fever, among others—are of global importance. Although vaccine development
chikungunya 30726 [[81]]. The wMel Wolbachia strain has the ability to reduce A. aegypti vectorial capacity to dengue and chikungunya viruses [[81],[82]], an encouraging result recently extended to Zika virus, as indicated by experimental
chikungunya 49292 Acevedo V, Felix GE, Hemme RR, Vazquez J, Munoz JL, Amador M. Impact of autocidal gravid ovitraps on chikungunya virus incidence in Aedes aegypti (Diptera: Culicidae) in areas with and without traps. Journal of medical
chikungunya 50586 biotechnology (2016): 34(1): 78–83. [[87]]Key learning pointsArboviruses such as dengue, Zika, and chikungunya are reemerging worldwide with increasing prevalence and/or severity.Decades of efforts have failed to
dengue fever 2194 1/2019Publication date (collection): 1/2019AbstractBackgroundMosquito-borne viruses—such as Zika, chikungunya, dengue fever , and yellow fever, among others—are of global importance. Although vaccine development for prevention
malaria 14973 implemented through a donor-subsidized market similar to that used for insecticide-treated bed nets against malaria .Studies have demonstrated that chemicals currently recommended for vector control can elicit varied
malaria 15769 reduction in human−vector contact, and coils have been shown to contribute to reduction in human malaria infection [[27],[28]]. Historically, the mode of action (MoA) of spatial repellent products has been
malaria 22492 workers from biting arthropods, and ITMs have reduced the incidence of vector-borne diseases such as malaria and leishmaniasis [[55]].Currently, an ITM strategy for vector control is in Stage 1 of VCAG evaluations
malaria 33916 frequency. This approach was illustrated by a recent proof-of-principle laboratory study in the African malaria vector Anopheles gambiae [[87]] and could rapidly be adapted to A. aegypti and A. albopictus. Gene drives
malaria 35652 genetic invasion progresses. Proof-of-principle has been demonstrated in the laboratory using the Asian malaria vector Anopheles stephensi [[92]]. In Aedes, antiviral constructs could be designed similarly, targeting
malaria 50435 Siniscalchi C, Katsanos D, et al. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature biotechnology (2016): 34(1): 78–83. [[87]]Key learning pointsArboviruses
yellow fever 2212 (collection): 1/2019AbstractBackgroundMosquito-borne viruses—such as Zika, chikungunya, dengue fever, and yellow fever , among others—are of global importance. Although vaccine development for prevention of mosquito-borne

You must be authorized to submit a review.