FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.

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Annotation Summary

Term Occurence Count Dictionary
glucose intolerance 1 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
Insulin 2 endocrinologydiseasesdrugs
alpha-linolenic acid 3 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases

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Review

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Select Drug Character Offset Drug Term Instance
Insulin 26665 concentration: serum phospholipid FA composition (relative %): SFA, MUFA, PUFA (ALA, LA, AA, EPA, DGLA, DPA, DHA) Insulin Resistance (HOMA)HOMA-IR and serum FA composition or FA ratios were associated with the FADS SNPs (rs174575
Insulin 28997 rs174602, rs498793, rs174546, rs174570, rs174579, rs174611, rs174616, rs968567Fasting Glucose (mM), Fasting Insulin (ρ/L), HOMA-IRSNPs involved in the FADS gene cluster were associated with glycemic control parameters
alpha-linolenic acid 5125 acids [[17]]. LC n-3 PUFA can be endogenously synthesized via metabolism of the essential fatty acid alpha-linolenic acid (ALA). This endogenous production is mediated by the enzymes delta-5-desaturase (D5D) and delta-6-desaturase
alpha-linolenic acid 25859 FADS1, respectively. LA: linoleic acid; DGLA: dihomo-gamma linolenic acid; AA: arachidonic acid; ALA: alpha-linolenic acid ; EPA: eicosapentaenoic acid; DPA: docosapentaenoic acid; DHA: docosahexaenoic acid.Figure 2Study selection
alpha-linolenic acid 31201 acids; SNP: single nucleotide polymorphism; T2DM: type 2 diabetes mellitus; AA: arachidonic acid; ALA: alpha-linolenic acid ; LA: linoleic acid; DGLA: dihomo gamma-linolenic acid; E: energy intake; EPA: eicosapentaenoic acid;
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1827 associations between FADS polymorphism and T2DM warrants further investigation.1. IntroductionType 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by an elevation of blood glucose levels (fasting glucose
diabetes mellitus 31155 tolerance test; FG: fasting glucose; FA: fatty acids; SNP: single nucleotide polymorphism; T2DM: type 2 diabetes mellitus ; AA: arachidonic acid; ALA: alpha-linolenic acid; LA: linoleic acid; DGLA: dihomo gamma-linolenic acid;
glucose intolerance 8277 diabetes’ OR ‘pre diabetes’ OR ‘insulin resistance’ OR ‘impaired glucose tolerance’ OR ‘ glucose intolerance ’). The search results were exported to a Reference Manager software, and were saved in a master file.
hyperinsulinemia 2164 biological response to the hormone insulin is impaired and insulin production is disregulated (compensatory hyperinsulinemia ) to maintain normoglycemia [[2],[3]]. The prevalence of T2DM and insulin resistance is increasing globally,
type 2 diabetes mellitus 31148 glucose tolerance test; FG: fasting glucose; FA: fatty acids; SNP: single nucleotide polymorphism; T2DM: type 2 diabetes mellitus ; AA: arachidonic acid; ALA: alpha-linolenic acid; LA: linoleic acid; DGLA: dihomo gamma-linolenic acid;

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