The risk factors of linezolid-induced lactic acidosis: A case report and review

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lactic acidosis 39 endocrinologydiseases
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metformin 11098 usually abrupt and the majority of patients developed serious respiratory failure. However, as we known, metformin can cause lactic acidosis too. A research including 253 cases showed that the mortality of metformin-associated
metformin 11199 metformin can cause lactic acidosis too. A research including 253 cases showed that the mortality of metformin -associated lactic acidosis was 17.2%.[[9]] The mortality of linezolid-induced lactic acidosis was considered
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lactic acidosis 53 Title: MedicineThe risk factors of linezolid-induced lactic acidosis A case report and reviewYiyang MaoDanping DaiHaiying JinYangyang WangJianxun Ding.Department of Pharmacy,
lactic acidosis 480 linezolid is increasingly used in multidrug-resistant bacteria therapy. At the same time, linezolid-induced lactic acidosis has been continually reported as a serious side effect. Notably, to our knowledge, there are limited
lactic acidosis 668 knowledge, there are limited available literatures that evaluate risk factors for linezolid-induced lactic acidosis , and there is no highly reliable study on the relationship between linezolid-induced lactic acidosis
lactic acidosis 769 lactic acidosis, and there is no highly reliable study on the relationship between linezolid-induced lactic acidosis and age or gender. However, clinicians need relevant information to advice on the use of linezolid.
lactic acidosis 936 relevant information to advice on the use of linezolid. Therefore, we report on a case of life-threatening lactic acidosis after 3 doses of linezolid exposure and evaluate the risk factors of linezolid-induced lactic acidosis.Methods:Cases
lactic acidosis 1039 lactic acidosis after 3 doses of linezolid exposure and evaluate the risk factors of linezolid-induced lactic acidosis .Methods:Cases of linezolid-induced lactic acidosis reported in PubMed were searched. Several characteristics
lactic acidosis 1090 and evaluate the risk factors of linezolid-induced lactic acidosis.Methods:Cases of linezolid-induced lactic acidosis reported in PubMed were searched. Several characteristics and data of case numbers and deaths were extracted
lactic acidosis 1361 including 47 cases were included in this study. Twelve patients (25.5%) died due to linezolid-induced lactic acidosis . At the cut-offs of 7, 14, and 28 days, the mortalities were 27.3%, 20%, and 27.3%. No statistically
lactic acidosis 1807 (proportion: 15.2% and 23.9%; mortality: 14.3% and 18.2%).Conclusion:The mortality of linezolid-induced lactic acidosis was relatively high. The duration of linezolid use and age might not be risk factors. Gender (specifically,
lactic acidosis 1992 be risk factors. Gender (specifically, male) might be related to the mortality of linezolid-induced lactic acidosis .Introduction1Linezolid, an oxazolidinone antimicrobial, was approved for clinical use by the US Food
lactic acidosis 2567 preventing fusion with the 30S subunit and formation of the initiation complex.[[1]]Linezolid-induced lactic acidosis has already been reported,[[2]] especially after prolonged use (≥28 days). It is a serious adverse
lactic acidosis 2843 death. We noticed that various linezolid treatments (range from 1 day[[3]] to 109 days)[[4]] can cause lactic acidosis . The incidence is relatively low but always life-threatening. Therefore, clinicians require relevant
lactic acidosis 3237 one is research from Korea,[[5]] which had collected and analyzed reported cases of linezolid-induced lactic acidosis . They concluded that a long period of use is not a prerequisite for death.[[5]] However, there were
lactic acidosis 4318 addition, to our knowledge, there is no highly reliable study on the relationship between linezolid-induced lactic acidosis and age or gender.Therefore, we searched for reported cases of linezolid-induced lactic acidosis and
lactic acidosis 4415 linezolid-induced lactic acidosis and age or gender.Therefore, we searched for reported cases of linezolid-induced lactic acidosis and extracted the data accurately to evaluate the risk factors. In addition, we also report a life-threatening
lactic acidosis 4550 data accurately to evaluate the risk factors. In addition, we also report a life-threatening case of lactic acidosis after 3 doses of linezolid exposure.Case report2A 57-year-old man was admitted to the Pneumology Department
lactic acidosis 6701 minipump to maintain a relatively normal pressure. As linezolid was implicated as a possible cause of the lactic acidosis , the agent was discontinued.The patient required mechanical ventilation because of respiratory failure
lactic acidosis 6948 replacement therapy for 6 days to normalize his blood pH and clear linezolid from his plasma. However, the lactic acidosis improved only marginally, and his blood pressure decreased to 30/22 mm Hg. The patient died on day 17.Data
lactic acidosis 7124 to 30/22 mm Hg. The patient died on day 17.Data sources2.1We searched for cases of linezolid-induced lactic acidosis reported in English in PubMed from their inception until April 2017. Literature searches included keywords
lactic acidosis 7289 inception until April 2017. Literature searches included keywords for “linezolid” or “Zyvox” and “ lactic acidosis ” or “hyper-lactatemia.”Case selection2.2Two reviewers (Yiyang Mao and Danping Dai) independently
lactic acidosis 7518 all titles and abstracts for eligible articles. Cases presented in the articles were included if the lactic acidosis was induced by linezolid and the data were extractable.Data extraction2.3Two authors extracted data
lactic acidosis 8009 dosage, lactate concentration before linezolid, peak lactate concentration after linezolid, treatment for lactic acidosis , and outcome.Seven, fourteen, and twenty-eight days were selected to be the cut-off points in statistics
lactic acidosis 8407 was assumed to be 600 mg/bid, when it was not reported according to the drug instruction. Only the lactic acidosis -related deaths were included when analyzing and evaluating the data. Patients ≥65 years were defined
lactic acidosis 9419 mean duration of linezolid use was 64.1 days. Twelve patients (25.5%) died due to linezolid-induced lactic acidosis . Of the 47 cases, 28 were males and 18 were females. One patient's gender and one male patient's age
lactic acidosis 9654 reported.Table 1Demographic, clinical, and laboratory characteristics of reported cases of linezolid-induced lactic acidosis .The summary of different durations of linezolid therapy is shown in Table 2. At the cut-offs of 7, 14,
lactic acidosis 10866 P = 1.000).Table 3Statistics of different sex and ages.Discussion4The mortality of linezolid-induced lactic acidosis (25.5%) in our study was similar to Im et al's data.[[5]] This may be because the onset of lactic acidosis
lactic acidosis 10973 acidosis (25.5%) in our study was similar to Im et al's data.[[5]] This may be because the onset of lactic acidosis was usually abrupt and the majority of patients developed serious respiratory failure. However, as we
lactic acidosis 11118 majority of patients developed serious respiratory failure. However, as we known, metformin can cause lactic acidosis too. A research including 253 cases showed that the mortality of metformin-associated lactic acidosis
lactic acidosis 11220 lactic acidosis too. A research including 253 cases showed that the mortality of metformin-associated lactic acidosis was 17.2%.[[9]] The mortality of linezolid-induced lactic acidosis was considered to be relatively high.Our
lactic acidosis 11287 mortality of metformin-associated lactic acidosis was 17.2%.[[9]] The mortality of linezolid-induced lactic acidosis was considered to be relatively high.Our study found that the mortality did not increase as the duration
lactic acidosis 11700 attention to the patients’ vital signs, no matter when the patients suffered the linezolid-induced lactic acidosis .The mortalities did not correlate with gender and age according to our statistical results. However,
lactic acidosis 11982 female patients in both age groups. Male patients seemed to be more susceptible to linezolid-induced lactic acidosis . Notably, male patients had twice the mortalities compared with female patients in both age groups.Because
lactic acidosis 12407 this may explain why the duration of linezolid was not a risk factor when gender might be related to lactic acidosis . As early as 2004, a research report from Taiwan indicated that there was a very strong association
lactic acidosis 12684 Stevens–Johnson syndrome.[[10]] If there exists a specific gene that is related to linezolid-induced lactic acidosis , screening for that gene can be performed prior to initiation of linezolid treatment to prevent the
lactic acidosis 12832 performed prior to initiation of linezolid treatment to prevent the occurrence of linezolid-induced lactic acidosis . However, as far as we know, limited genetic association studies have been performed. For example, Palenzuela
lactic acidosis 13568 severity. Thus, some bias may exist in this study.In conclusion, the mortality of linezolid-induced lactic acidosis was considered to be relatively high. Duration of linezolid therapy might not be a risk factor for death
lactic acidosis 13718 high. Duration of linezolid therapy might not be a risk factor for death related to linezolid-induced lactic acidosis . The mortalities did not correlate with gender and age according to the statistical results. However,
lactic acidosis 13892 according to the statistical results. However, male patients had high mortality from linezolid-induced lactic acidosis . Linezolid's potential-associated lactic acidosis requires systematic monitoring during clinical therapy.
lactic acidosis 13942 patients had high mortality from linezolid-induced lactic acidosis. Linezolid's potential-associated lactic acidosis requires systematic monitoring during clinical therapy. The genetic factor could be considered in future

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