Hookworm-related anaemia among pregnant women: a systematic review

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Term Occurence Count Dictionary
infectious disease 1 infectiousdiseases
malaria 7 infectiousdiseases
mebendazole 9 infectiousdiseasesdrugs
schistosomiasis 1 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
mebendazole 6059 addressed directly by de Silva and colleagues [11], who analysed the safety profile of some 20 years of mebendazole use in antenatal clinics in Sri Lanka. In 2002, WHO published new guidance indicating that pregnant
mebendazole 20294 were found to be linked to albendazole. The RCT in Peru found no significant difference between the mebendazole and placebo groups in the frequency of miscarriages, malformations, stillbirths, early neonatal deaths
mebendazole 20518 premature babies [24],[26].10.1371/journal.pntd.0000291.t002Table 2The impact of anthelmintic treatment ( mebendazole (MBZ) or albendazole (ABZ)) on the health of pregnant women in the developing world.StudyCountryPrevalence
mebendazole 23784 Sri Lanka also showed that treatment increased Hb in pregnant women, and found that providing both mebendazole and iron supplementation had a greater impact on Hb than iron supplementation alone [28]. The observational
mebendazole 24210 [29]. The other observational study on pregnant women, in India, also found that co-administration of mebendazole and iron supplementation resulted in improved Hb [30].Burden of hookworm in pregnant women in sub-Saharan
mebendazole 27954 haemoglobin that typically occurs during pregnancy [25], but that the effect was less apparent with mebendazole [24]. This may reflect the lower efficacy of mebendazole versus albendazole in treating hookworm infection
mebendazole 28011 but that the effect was less apparent with mebendazole [24]. This may reflect the lower efficacy of mebendazole versus albendazole in treating hookworm infection [42],[43]. However, there is a trade-off between efficacy
mebendazole 28148 treating hookworm infection [42],[43]. However, there is a trade-off between efficacy and safety since mebendazole is poorly absorbed from the gut whereas albendazole is turned into a sulfoxide metabolite that gets
mebendazole 29659 treatement. This is consistent with other observational studies which have investigated the safety of mebendazole in pregnant women (for a recent review of studies, see [26]). We feel that the findings of the present
Select Disease Character Offset Disease Term Instance
infectious disease 26310 [37]–[38]. Anaemia in developing countries has multiple causes, including micro-nutrient deficiencies, infectious disease s and inherited disorders [39], and as such, the observed relationship between Hb and hookworm infection
malaria 5167 example, iron supplementation [5], long-lasting insecticide nets and intermittent preventive treatment for malaria [6]–[7].Hookworm infection has long been recognized among the major causes of anaemia in poor communities
malaria 28686 underlying aetiologies of anaemia may be relevant, such differences in iron deficiency anaemia and malaria and schistosome transmission intensity [39]. Finally, although we did not quantitatively assess the
malaria 30356 among populations whose diets is low in bioavailable iron [10]. In addition, a review of the impact of malaria -related anaemia among pregnant women in sub-Saharan Africa suggested that over a quarter of cases of
malaria 30501 in sub-Saharan Africa suggested that over a quarter of cases of severe anaemia were attributable to malaria [44], while other evidence shows that anaemia burden can be reduced effectively by anti-malarial intermittent
malaria 30597 to malaria [44], while other evidence shows that anaemia burden can be reduced effectively by anti- malaria l intermittent preventive treatment (IPT) [7]. An effective package to improve maternal anaemia should
malaria 31278 important than the numerous other factors that may introduce heterogeneity [17], such as transmission of malaria and schistosomiasis, iron and nutritional intake, diagnostic accuracy in quantifying Hb and hookworm
malaria 33683 treatment and iron supplementation, with, where appropriate, intermittent preventive treatment for malaria
schistosomiasis 31290 the numerous other factors that may introduce heterogeneity [17], such as transmission of malaria and schistosomiasis , iron and nutritional intake, diagnostic accuracy in quantifying Hb and hookworm intensity. Furthermore,

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