Global and gene-specific DNA methylation in adult type 2 diabetic individuals: a protocol for a systematic review.

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Term Occurence Count Dictionary
type 2 diabetes mellitus 2 endocrinologydiseases
diabetes mellitus 5 endocrinologydiseases
metabolic syndrome 3 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs
obesity 2 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
metformin 11508 (CVD).Data simplificationStudies that mention that participants were on diabetic treatment (such as metformin ) and those who were not on diabetic treatment will be grouped as the treatment group and the non-treatment
Select Disease Character Offset Disease Term Instance
diabetes mellitus 451 gene-specific) has been reported as an epigenetic mechanism that could be involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Furthermore, epigenetic therapy has been suggested as a future possibility for T2DM treatment.
diabetes mellitus 2901 (10.1186/s13643-018-0708-7) contains supplementary material, which is available to authorized users.BackgroundType 2 diabetes mellitus (T2DM) is a complex and multifactorial metabolic disorder caused by genetic and environmental factors
diabetes mellitus 5173 hypomethylation has been associated with gene activation [[10]]. Several studies have reported the link between diabetes mellitus and DNA methylation (gene-specific as well as global). For global DNA methylation, some studies reported
diabetes mellitus 5684 hypermethylation) could be due to the different study populations, techniques used or different conditions of the diabetes mellitus and metabolic syndrome parameters in the studies. Therefore, these discrepancies warrant doing a systematic
diabetes mellitus 8080 search strategy will be developed using medical subheadings (MeSH) and key words related to type 2 diabetes mellitus and DNA methylation. The key words and MeSH terms will include hyperglycaemia, epigenetics, global DNA
metabolic syndrome 5706 the different study populations, techniques used or different conditions of the diabetes mellitus and metabolic syndrome parameters in the studies. Therefore, these discrepancies warrant doing a systematic review in the light
metabolic syndrome 5949 of DNA methylation as a possible biomarker, risk factor and prognostic marker for T2DM and the other metabolic syndrome conditions. Moreover, DNA methylation is reversible, thus enabling intervention strategies to possibly
metabolic syndrome 11319 individuals. The secondary outcome would be to assess the DNA methylation profile results in different metabolic syndrome parameters or risk factors such as obesity and cardiovascular disease (CVD).Data simplificationStudies
obesity 11373 DNA methylation profile results in different metabolic syndrome parameters or risk factors such as obesity and cardiovascular disease (CVD).Data simplificationStudies that mention that participants were on diabetic
obesity 12880 of the methylation status association with glycaemic status and other risk factors of T2DM such as obesity , cholesterolaemia and CVD will be reported.Quantitative synthesisIn case of excessive heterogeneity,
type 2 diabetes mellitus 444 gene-specific) has been reported as an epigenetic mechanism that could be involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Furthermore, epigenetic therapy has been suggested as a future possibility for T2DM treatment.
type 2 diabetes mellitus 8073 strategyThe search strategy will be developed using medical subheadings (MeSH) and key words related to type 2 diabetes mellitus and DNA methylation. The key words and MeSH terms will include hyperglycaemia, epigenetics, global DNA

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