A novel and compact review on the role of oxidative stress in female reproduction

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Annotation Summary

Term Occurence Count Dictionary
Insulin 1 endocrinologydiseasesdrugs
acetylcysteine 1 endocrinologydiseasesdrugs
hyperandrogenism 1 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
polycystic ovary syndrome 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

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Select Drug Character Offset Drug Term Instance
Insulin 24129 OS↑Physiological hyperglycemia → ROS↑ (Monocytes) → TNF-α↑ → NF-κB↑ → Resistance of Insulin ↑[[45], [46]]Preeclampsia:Defective placenta → Hypoxia and reperfusion injury → OS↑ → Cytokines↑,
acetylcysteine 36048 and cell proliferation, and it also promotes the apoptosis of endometriotic cells. Additionally, N- acetylcysteine (NAC) and vitamin E are antioxidants that limit the proliferation of endometriotic cells, likely by
Select Disease Character Offset Disease Term Instance
hyperandrogenism 27813 reproductive-aged women and has a prevalence of approximately 18%. It is a disorder characterized by hyperandrogenism , ovulatory dysfunction, and polycystic ovaries [[45]]. Various studies have reflected the presence of
hyperglycemia 24034 functional↑ROS↑ → Antioxidants↑ → Synthesis of progesterone[[39]]Negative effectPCOS:Serum proline activity↑, OS↑Physiological hyperglycemia → ROS↑ (Monocytes) → TNF-α↑ → NF-κB↑ → Resistance of Insulin↑[[45], [46]]Preeclampsia:Defective
hyperglycemia 28312 with increased ROS production, explains the mitochondrial dysfunction in PCOS patients. Physiological hyperglycemia generates increased levels of ROS from mononuclear cells, which activate the release of tumor necrosis
polycystic ovary syndrome 1206 explaining the role of OS in female reproduction and female reproductive diseases caused by OS, including polycystic ovary syndrome (PCOS), endometriosis, preeclampsia and so on. Many signaling pathways involved in female reproduction,

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