Retinoid X Receptor Antagonists

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Annotation Summary

Term Occurence Count Dictionary
Fluvastatin 1 endocrinologydiseasesdrugs
rosiglitazone 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
Fluvastatin 38715 HEK-293T cells)[[71]]27Kd = 488 nM(RXRα-LBD, SPR)IC50 = 2.45 μM(vs. 1 @ 0.1 μM, HEK-293T cells)[[71]] Fluvastatin (28)Kd = 11.04 μM(RXRα-LBD, SPR)IC50 value is not described.(vs. 1 @ 100 nM, MCF-7 cells)[[72]]Pitavastatin
rosiglitazone 23349 antagonizes RXR in RXR/RAR heterodimer [[48]]. One micromole of 12 suppressed the activity of 100 nM rosiglitazone (PPARγ agonist) toward PPARγ/RXR to about a half [[7]]. Compound 17a has antagonistic activity not
Select Disease Character Offset Disease Term Instance

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