Recent Advances in Mitochondria-Targeted Gene Delivery

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Term Occurence Count Dictionary
calcium carbonate 1 endocrinologydiseasesdrugs
lactic acidosis 1 endocrinologydiseases
mitochondrial disease 12 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
calcium carbonate 11945 charge. The rhodamine-plasmid DNA nanoparticle complex can be easily prepared by co-precipitation with calcium carbonate . An addition of cellulose increased the stability of the complex in aqueous solution and reduced its
Select Disease Character Offset Disease Term Instance
lactic acidosis 35783 syndrome, A8344G associated with MERRF, and A3243G, which may lead to mitochondrial encephalopathy, lactic acidosis , and stroke-like episodes (MELAS) [[60],[61],[62],[63],[64]]. To specifically destroy mitochondrial
mitochondrial disease 815 ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial disease s often result from mutations of mitochondrial genomes and nuclear genes that encode the mitochondrial
mitochondrial disease 3479 to lead to a disease phenotype. However, if the percentage is over the threshold (typically >80%), mitochondrial disease occurs [[4]]. Based on this heteroplasmic feature of mtDNA, it might be possible to recover mitochondrial
mitochondrial disease 4783 molecules encoding the corrected versions of genes into mitochondria is a promising strategy to treat mitochondrial disease . Due to the impermeability of the mitochondrial inner membrane to hydrophilic molecules, however, passage
mitochondrial disease 5336 cargo DNA are also introduced. At last, we highlight the applications of these strategies to treat mitochondrial disease s.2. Physical ApproachesPhysical gene delivery systems can provide a simple and direct way to transfer
mitochondrial disease 35188 strategy may allow the production of functional proteins required for normal mitochondrial activity in mitochondrial disease when various approaches are applied for mitochondrial gene delivery.In contrast to the above-mentioned
mitochondrial disease 37227 mtDNA cause a number of diseases and the major sites of mutations are well known [[65]]. For example, mitochondrial disease s such as MERRF disease are caused by the A8344G mutation in the tRNAPhe-coding gene. Neurogenic muscle
mitochondrial disease 37619 Kearns-Sayre syndrome, Ataxia neuropathy syndrome, and Alpers-Huttenlocher [[66]].LHON is a well-studied mitochondrial disease . It involves retinal ganglion cell death and degeneration of optic nerves. Over 90% of LHON patients
mitochondrial disease 38865 atrophy was relieved by the wild type ND4 allele [[27]].MELAS are other well-known symptoms of the mitochondrial disease caused by various point mutations in the NADH dehydrogenase gene or mitochondrial tRNA-coding genes
mitochondrial disease 40544 mitochondrial dysfunction. Instead, several groups have attempted to transfer genes to cells under mitochondrial disease states without mitochondria-targeting. Previously, the yeast NDI1 gene encoding NADH-quinone oxidoreductase
mitochondrial disease 41889 possess many copies of their genome and, thus, only a small percentage of mutated alleles do not cause mitochondrial disease . This feature can be exploited to treat mitochondrial diseases caused by genetic mutations in mtDNA
mitochondrial disease 41951 percentage of mutated alleles do not cause mitochondrial disease. This feature can be exploited to treat mitochondrial disease s caused by genetic mutations in mtDNA by complementing essential genes. The major challenge of gene
mitochondrial disease 42606 have reported successful delivery of genetic cargo and transgene expression in cells or animals with mitochondrial disease . Various approaches have been used to deliver wild type genes into the mitochondrial matrix and have

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