Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis

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calcitriol 1 endocrinologydiseasesdrugs
metabolic bone disease 1 endocrinologydiseases
osteoporosis 31 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
calcitriol 28338 criteriaNREG:60.52±6.25CG:61.12±5.87Postmenopausal osteoporosisTC (45–60 minutes/session, one to two sessions/day) + calcitriol capsuleCalcitriol6 monthsBMD (DEXA, g/cm2) quality of life (SF-36), therapeutic effectZhao et al 2015[53]EG:30CG:30WHO
Select Disease Character Offset Disease Term Instance
metabolic bone disease 29402 collagen; DEXA, dual energy X-ray absorptiometry; EG, experimental group; Hyp, hydroxyproline; MBD, metabolic bone disease s; MENQOL, Menopause Quality of Life instrument; NR, not reported; OSC, osteocalcin; PAR, Seven-Day Physical
osteoporosis 82 Title: Clinical Interventions in AgingTai chi for treating osteopenia and primary osteoporosis : a meta-analysis and trial sequential analysisYili ZhangYan ChaiXiaojie PanHao ShenXu WeiYanming Xie1Institute
osteoporosis 941 meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis .MethodsWe went through eight databases to identify relevant randomized controlled trials that compared
osteoporosis 1106 relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis -related fractures (fracture incidence). Meta-analyses and trial sequential analyses (TSA) were conducted
osteoporosis 2609 However, due to the low methodological quality, current evidence for treating osteopenia and primary osteoporosis through TC is insufficient.IntroductionPrimary osteoporosis (POP) is a worldwide health problem with
osteoporosis 2669 evidence for treating osteopenia and primary osteoporosis through TC is insufficient.IntroductionPrimary osteoporosis (POP) is a worldwide health problem with a consequent increase in bone fragility and susceptibility
osteoporosis 2967 deterioration of bone tissue.[2],[3] Osteopenia is a condition of decreased bone density and a precursor of osteoporosis .[4] Osteoporosis affects about 200 million people worldwide and is a huge cost for the healthcare system.
osteoporosis 3179 system. This cost is estimated to increase to $25.3 billion per year.[5]Pharmacologic treatments for osteoporosis include bisphosphonates, estrogen, selective estrogen receptor modulators, and so forth.[6]–[8] The
osteoporosis 3960 physiological effects on the body.[10] Considering the side effect of pharmacological treatment for osteoporosis , there is an increasing demand for nonpharmacologic therapy, such as physiotherapy and physical activity
osteoporosis 5180 effectiveness of the whole-body vibration training, and in particular, its positive effects on bone turnover in osteoporosis .[15]–[17]Tai chi (TC) is a traditional systematic physical activity, which is widely practiced not
osteoporosis 5811 Aside from pharmacological methods, muscle strengthening and weight-bearing exercises, which prevent osteoporosis by increasing bone and muscle strength as well as coordination and balance, TC is often recommended
osteoporosis 6246 osteoarthritis and fibromyalgia.[23]–[25]Moreover, clinical trials assessing TC treatment for osteopenia and osteoporosis have recently been published and may have strengthened the evidence base that TC is one of the nonpharmacological
osteoporosis 6753 regulating the bone mass, especially for the patients with osteopenia and POP and those at high risk of osteoporosis . Furthermore, we examined whether the current evidence was robust and conclusive by using trial sequential
osteoporosis 7925 on were osteopenia and POP so that the participants with osteopenia and POP or those at high risk of osteoporosis (mean age >50 years old) were included. The clinical diagnosis for osteopenia or POP should be in accordance
osteoporosis 8190 instance WHO criteria: bone mineral density (BMD) of subjects, T-score ≤-2.5 could be defined as osteoporosis and T-scores in the range of −2.5 and −1 could be defined as osteopenia.[28] In addition, Chinese
osteoporosis 8458 standard deviation] >M – 1 SD ~2 SD could be defined as osteopenia and <M – 2 SD could be diagnosed as osteoporosis ) were included as well.[29]Types of interventionsIn order to estimate the specific effect of TC, only
osteoporosis 9271 recommended by national guidelines, such as Clinical guidelines for diagnosis and treatment of postmenopausal osteoporosis (AACE/ACE),[30] Clinician’s Guide to Prevention and Treatment of Osteoporosis (NOF),[31] and Guideline
osteoporosis 9428 Prevention and Treatment of Osteoporosis (NOF),[31] and Guideline for diagnosis and treatment of primary osteoporosis (CSOBMR).[32] Usually, calcium and vitamin D supplements are also considered as conventional treatment.
osteoporosis 9597 are also considered as conventional treatment. Other complementary and alternative treatments (eg, osteoporosis bone protective medication, physiotherapy, osteopathy, orthoses, herbal medicine, acupuncture, moxibustion,
osteoporosis 10874 identify additional relevant studies.The following search terms were used in separate or combined ways: “ osteoporosis ”; “primary osteoporosis”; “postmenopausal osteoporosis”; “senile osteoporosis”; “osteopenia”;
osteoporosis 10902 studies.The following search terms were used in separate or combined ways: “osteoporosis”; “primary osteoporosis ”; “postmenopausal osteoporosis”; “senile osteoporosis”; “osteopenia”; “bone loss”;
osteoporosis 10937 used in separate or combined ways: “osteoporosis”; “primary osteoporosis”; “postmenopausal osteoporosis ”; “senile osteoporosis”; “osteopenia”; “bone loss”; “Tai chi”; “Tai ji”; “Tai
osteoporosis 10964 ways: “osteoporosis”; “primary osteoporosis”; “postmenopausal osteoporosis”; “senile osteoporosis ”; “osteopenia”; “bone loss”; “Tai chi”; “Tai ji”; “Tai chichuan”; “Shadow Boxing”;
osteoporosis 23275 studies indicated that vitamin D and calcium supplementation are the most widely used therapies for osteoporosis .[59] Observational studies suggest that lower plasma levels of 25-hydroxy-vitamin D (25[OH]D) are associated
osteoporosis 23418 suggest that lower plasma levels of 25-hydroxy-vitamin D (25[OH]D) are associated with higher risks of osteoporosis [60],[61] and fractures.[62] Also, calcium and vitamin D supplements have been recommended for older
osteoporosis 26312 femur, g/cm2)Song 2008[45]EG:20CG:20Chinese criteriaEG:9/11CG:10/10EG:62.67±11.23CG:63.81±13.07Primary osteoporosis TC (60 minutes/session, six sessions per week)Calcium preparations + calcitonin (no details provided)NRBMD
osteoporosis 27371 weeksQuantitative ultrasound, Ca, P, ALPZhang 2011[49]EG:36CG:36WHO criteria28/44EG:58.4±3.0CG:58.0±2.8Primary osteoporosis TC (30–60 minutes/session, three to four sessions/week) + Caltrate D (600 mg/qd)Caltrate D (600 mg/qd)24
osteoporosis 28270 coordinationShan and Kang 2015[52]EG:54CG:56Chinese criteriaNREG:60.52±6.25CG:61.12±5.87Postmenopausal osteoporosis TC (45–60 minutes/session, one to two sessions/day) + calcitriol capsuleCalcitriol6 monthsBMD (DEXA,
osteoporosis 28524 therapeutic effectZhao et al 2015[53]EG:30CG:30WHO criteriaEG:14/16CG:12/18EG:58.8±3.2CG:61.1±2.8Primary osteoporosis TC (55 minutes/session, six sessions/week)No intervention6 monthsBMD (DEXA, femoral neck, Ward triangle,
osteoporosis 29612 PAR, Seven-Day Physical Activity Recall; P, phosphorus; Pi, inorganic phosphorus; PMOP, postmenopausal osteoporosis ; SF-36, 36-Item Short Form Health Survey; TC, Tai chi; WHO, World Health Organisation.Table 2The results
osteoporosis 31854 applicable.Table 3The results of all outcomes for three subgroups: participants with osteopenia and osteoporosis SubgroupsCategoriesOutcomesNumber of studiesRisk ratio or mean difference (95% CI)P-valueP for heterogeneityI2
osteoporosis 33987 RCTs551115ParticipantsOsteoporosisPostmenopausal womenPerimenopausal and postmenopausal womenOsteopenia and primary osteoporosis Search strategy until (year)2007201220152017Protocol registeredNANANAAppliedTrial sequential analysisNANANAAppliedOutcomesBMDBMDBMD,

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