Development of an In Vitro Screening Platform for the Identification of Partial PPARγ Agonists as a Source for Antidiabetic Lead Compounds

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs
miglitol 1 endocrinologydiseasesdrugs
rosiglitazone 1 endocrinologydiseasesdrugs
Insulin 9 endocrinologydiseasesdrugs
dexamethasone 1 endocrinologydiseasesdrugs
obesity 4 endocrinologydiseases
pioglitazone 1 endocrinologydiseasesdrugs
repaglinide 1 endocrinologydiseasesdrugs
acarbose 1 endocrinologydiseasesdrugs
hyperglycemia 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 2435 from type 2 diabetes (T2D), and this number is projected to rise to around 642 million by 2040 [[1]]. Insulin resistance plays an essential role in the development of T2D, and is characterized by glucose intolerance
Insulin 2588 development of T2D, and is characterized by glucose intolerance resulting in elevated fasting glucose. Insulin resistance is mediated by high circulating levels of free fatty acids and by the release of certain
Insulin 3120 free fatty acids and leptin increases energy expenditure leading to a reduction in insulin resistance. Insulin resistance is the prediabetic state where insulin sensitive tissues such as muscles and fat show reduced
Insulin 11789 compounds from these plant species [[47],[48]], and this will be described in the following sections.3. Insulin -Dependent and Basal GUInsulin plays an essential role in glucose homeostasis by increasing storage or
Insulin 11819 [[47],[48]], and this will be described in the following sections.3. Insulin-Dependent and Basal GU Insulin plays an essential role in glucose homeostasis by increasing storage or utilization of glucose by regulating
Insulin 14056 insulin trafficking.3.1. Identification of Potential Antidiabetic Compounds from Plants with Effect on Insulin -Dependent GUTo study insulin-dependent GU in adipocytes two approaches can be used. Firstly, one can
Insulin 14974 insulin to determine basal GU [[47],[48]].3.1.1. Alkamides in the Roots of E. purpurea Show an Effect on Insulin -Dependent GUIn a recent study by Kotowska et al. [[47]], it was demonstrated that a dichloromethane
Insulin 17050 further studies in the screening platform.3.1.2. Polyacetylenes from Carrot Roots Show an Effect on Insulin -Dependent GUIn a study by El-Houri et al. [[48]], it has recently been shown that the DCM extract of
Insulin 44200 and FaDOH on insulin-dependent GU in mature 3T3-L1 adipocytes relative to 0.1% DMSO (vehicle, 100%). Insulin concentration was 10 nM, and the positive control was Rosi (1 μM). All values are expressed as a mean
acarbose 3928 (e.g., metformin) increase insulin sensitivity (insulin sensitizers), α-glucosidase inhibitors (e.g., acarbose and miglitol) work by preventing the digestion of starch and other carbohydrates in the small intestine
dexamethasone 26719 3T3-L1 preadipocytes into mature adipocytes, a cocktail consisting of the synthetic glucocorticoid dexamethasone , 1-methyl-3-isobutylxanthine, and insulin (MDI protocol) is often used [[40],[41],[47],[48],[84]].PPARγ
metformin 3832 as sulfonylureas and meglitinides (e.g., repaglinide) increase insulin secretion, biguanides (e.g., metformin ) increase insulin sensitivity (insulin sensitizers), α-glucosidase inhibitors (e.g., acarbose and miglitol)
miglitol 3941 metformin) increase insulin sensitivity (insulin sensitizers), α-glucosidase inhibitors (e.g., acarbose and miglitol ) work by preventing the digestion of starch and other carbohydrates in the small intestine and the thiazolidinediones
pioglitazone 4108 carbohydrates in the small intestine and the thiazolidinediones (TZDs) such as rosiglitazone (Rosi) and pioglitazone are efficient insulin-sensitizing drugs [[4],[5],[6],[7]]. TZDs act by activating peroxisome proliferator-activated
repaglinide 3773 oral anti-hyperglycemic drugs. Anti-hyperglycemic drugs such as sulfonylureas and meglitinides (e.g., repaglinide ) increase insulin secretion, biguanides (e.g., metformin) increase insulin sensitivity (insulin sensitizers),
rosiglitazone 4083 of starch and other carbohydrates in the small intestine and the thiazolidinediones (TZDs) such as rosiglitazone (Rosi) and pioglitazone are efficient insulin-sensitizing drugs [[4],[5],[6],[7]]. TZDs act by activating
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2287 PPARγ agonism.1. IntroductionIn 2015, it was estimated that more than 415 million adults globally had diabetes mellitus , of which over 90% suffered from type 2 diabetes (T2D), and this number is projected to rise to around
glucose intolerance 2529 [[1]]. Insulin resistance plays an essential role in the development of T2D, and is characterized by glucose intolerance resulting in elevated fasting glucose. Insulin resistance is mediated by high circulating levels of
hyperglycemia 3519 homeostasis. Eventually, the β-cells fail to sustain a sufficient insulin production resulting in hyperglycemia and T2D [[2],[3]].Patients suffering from T2D are treated with life-style changes including exercise
hypertriglyceridemia 25577 [[79],[80]]. Therefore, overexpression of SCD1 in humans may be involved in the development of T2D, hypertriglyceridemia , and atherosclerosis.Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major
obesity 19259 Furthermore, SRC-1-deficient mice have been shown to have reduced energy expenditure and to be susceptible to obesity ; thus SRC-1 is a beneficial coactivator [[66],[67],[68]]. PPARγ coactivator 1-α (PGC-1α) is a key
obesity 25324 upregulation of SCD1 leads to increased lipogenesis and elevated levels of SCD1 is associated with obesity . This is also in accordance with the fact that SCD1-deficient or knockout mice are protected from obesity
obesity 25430 obesity. This is also in accordance with the fact that SCD1-deficient or knockout mice are protected from obesity and show increased insulin sensitivity [[79],[80]]. Therefore, overexpression of SCD1 in humans may
obesity 26042 impair insulin-signaling [[81],[82]]; hence, the regulation of ATGL and HSL are important in relation to obesity , T2D, and related metabolic disorders.5.1. Adipocyte Differentiation Bioassays and Gene ExpressionPPARγ

You must be authorized to submit a review.