The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions

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Term Occurence Count Dictionary
hypoglycemia 2 endocrinologydiseases
type 1 diabetes mellitus 2 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases
Etanercept 2 endocrinologydiseasesdrugs
Exenatide 1 endocrinologydiseasesdrugs
Insulin 1 endocrinologydiseasesdrugs
Liraglutide 1 endocrinologydiseasesdrugs
diabetes mellitus 5 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Etanercept 32525 proliferation[[107]]SirolimusRapamunemTOR inhibitor, inhibits T/B cell proliferation[[108]]EverolimusZortress/CerticanmTOR inhibitor[[106]] Etanercept EnbrelTNF-α inhibitor[[106]]Anti-CD154-mAbBlockage of CD40/CD154 T cell costimulation[[109]]Abatacept
Etanercept 33040 cells[[112]]Anti-inflammationAdalimumabHumiraAnti-TNF α-mAb (human)[[113]]InfliximabRemicadeAnti-TNF α-mAb (chimeric human-mouse)[[114]] Etanercept EnbrelSoluble TNF receptor fusion protein[[106]]AnakinraKineretIL-1β receptor antagonist[[115]]A1AT
Exenatide 30739 inhibitorAnti-inflammatory effects by reduction of PIC productionAntiapoptotic effects via JNK inhibitionGLP-1 R agonist(i) Exenatide (short half-life)(ii) Liraglutide (long half-life)Reducing apoptosis due to oxidative stress & enhancing
Insulin 1270 interventions to promote islet allograft survival and improve long-term graft function.1. Introduction Insulin deficiency caused by autoimmune injury of islet β cells is the primary cause of type 1 diabetes mellitus
Liraglutide 30771 productionAntiapoptotic effects via JNK inhibitionGLP-1 R agonist(i) Exenatide (short half-life)(ii) Liraglutide (long half-life)Reducing apoptosis due to oxidative stress & enhancing insulin releaseAnti-inflammatory
Select Disease Character Offset Disease Term Instance
diabetes mellitus 459 /2018Publication date (epub): 9/2018AbstractPancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining widespread attention because this approach can restore physiological insulin secretion, minimize
diabetes mellitus 1366 IntroductionInsulin deficiency caused by autoimmune injury of islet β cells is the primary cause of type 1 diabetes mellitus (T1DM). Islet replacement therapy (insulin-secreting pancreas transplantation or islet transplantation)
diabetes mellitus 7594 transplantation in mice [[32]–[35]] and for autologous stem cell infusion in patients with type 2 diabetes mellitus [[36]], providing therapeutic potential for human islet transplantation. Most of the abovementioned
diabetes mellitus 25022 insulin infusion, and strict blood glucose monitoring have made great progress in the treatment of diabetes mellitus , it remains difficult to achieve physiologically precise regulation of blood glucose. The replacement
diabetes mellitus 26379 properly addressed, hurdle limiting the wider use of islet transplantation in T1DM and partial type 2 diabetes mellitus will be the insufficiency of islet allograft donors.The search for alternative sources of islets is
hypoglycemia 666 secretion, minimize the risk of hypoglycemic unawareness, and reduce the risk of death due to severe hypoglycemia . However, there are many obstacles contributing to the early mass loss of the islets and progressive
hypoglycemia 25333 for T1DM and has proven to be very beneficial to patients. Islet transplantation can prevent severe hypoglycemia , improve haemoglobin A1C, prevent/reverse complications, and in many cases even achieve sustained periods
type 1 diabetes mellitus 452 /2018Publication date (epub): 9/2018AbstractPancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining widespread attention because this approach can restore physiological insulin secretion, minimize
type 1 diabetes mellitus 1359 IntroductionInsulin deficiency caused by autoimmune injury of islet β cells is the primary cause of type 1 diabetes mellitus (T1DM). Islet replacement therapy (insulin-secreting pancreas transplantation or islet transplantation)
type 2 diabetes mellitus 7587 islet transplantation in mice [[32]–[35]] and for autologous stem cell infusion in patients with type 2 diabetes mellitus [[36]], providing therapeutic potential for human islet transplantation. Most of the abovementioned
type 2 diabetes mellitus 26372 are properly addressed, hurdle limiting the wider use of islet transplantation in T1DM and partial type 2 diabetes mellitus will be the insufficiency of islet allograft donors.The search for alternative sources of islets is

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