Helminth genomics: The implications for human health

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Annotation Summary

Term Occurence Count Dictionary
ivermectin 1 infectiousdiseasesdrugs
necatoriasis 1 infectiousdiseases
schistosomiasis 6 infectiousdiseases
strongyloidiasis 1 infectiousdiseases
taeniasis 1 infectiousdiseases
ascariasis 1 infectiousdiseases
clonorchiasis 1 infectiousdiseases
filariasis 6 infectiousdiseases
trichuriasis 1 infectiousdiseases
tuberculosis 1 infectiousdiseases
cysticercosis 1 infectiousdiseases
praziquantel 1 infectiousdiseasesdrugs
AIDS 2 infectiousdiseases
malaria 2 infectiousdiseases
urinary schistosomiasis 1 infectiousdiseases
intestinal schistosomiasis 2 infectiousdiseases
onchocerciasis 1 infectiousdiseases
trichinosis 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
ivermectin 38868 year, depends almost exclusively on just two or three drugs: praziquantel, the benzimidazoles, and ivermectin . Vaccines and new drugs are needed, certainly because drug resistance in human helminth parasites such
praziquantel 38830 for hundreds of thousands of deaths each year, depends almost exclusively on just two or three drugs: praziquantel , the benzimidazoles, and ivermectin. Vaccines and new drugs are needed, certainly because drug resistance
Select Disease Character Offset Disease Term Instance
AIDS 2547 development, pregnancy, and productivity—rivals that of the main high-mortality conditions such as HIV/ AIDS or malaria [1]. For example, based on a recent analysis [2], 85% of the neglected tropical disease (NTD)
AIDS 3181 number of cases of schistosomiasis and possibly associated with increased horizontal transmission of HIV/ AIDS . Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread
ascariasis 13261 progressSIS. rattiModel threadwormRat——27.4In progressSI/WUGCClade IIIAscaris lumbricoidesLarge roundworm/ ascariasis Human230—1.8In progressSIA. sumModel large roundwormPig230—55.7Improving draftWUGC/SIBrugia malayiFilaria/lymphatic
clonorchiasis 14549 fluke/intestinal schistosomiasisHuman40029491104Draft completedCNHGCClonorchis sinensisLiver fluke/ clonorchiasis Human—179753In progressSNUCMaWUGC, Washington University's Genome Center.bPhylogeny based on Blaxter
cysticercosis 14189 hydatidosisCanids; larva infects humans1501262010In progressSITaenia soliumPork tapeworm/taeniasis/ cysticercosis Human2701781525Draft completedMexico CityTrematoda (flukes)Schistosoma mansoniBlood fluke/intestinal
filariasis 3197 schistosomiasis and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease
filariasis 4470 Brugia malayi in a thick blood smear, stained with Giemsa (http://www.dpd.cdc.gov/dpdx/html/frames/a-f/ filariasis /body_Filariasis_mic1.htm); the microfilaria is about 250 µm in length. (B) Patient with lymphedema
filariasis 4614 microfilaria is about 250 µm in length. (B) Patient with lymphedema of the left leg due to lymphatic filariasis (http://www.cdc.gov/ncidod/dpd/parasites/lymphaticfilariasis/index.htm). (C) Hookworm egg passed in
filariasis 4675 lymphedema of the left leg due to lymphatic filariasis (http://www.cdc.gov/ncidod/dpd/parasites/lymphatic filariasis /index.htm). (C) Hookworm egg passed in the stool of an infected person; the microscopic egg, barrel-shaped
filariasis 13391 progressSIA. sumModel large roundwormPig230—55.7Improving draftWUGC/SIBrugia malayiFilaria/lymphatic filariasis Human96954926.2Improving draftTIGR/University of PittsburghLoa LoaFilaria/loaisis (cutaneous filariasis)/African
filariasis 13494 filariasisHuman96954926.2Improving draftTIGR/University of PittsburghLoa LoaFilaria/loaisis (cutaneous filariasis )/African eye wormHuman——3.3In progressBIOnchocerca volvulusFilaria/river blindnessHuman150—15In
intestinal schistosomiasis 14292 tapeworm/taeniasis/cysticercosisHuman2701781525Draft completedMexico CityTrematoda (flukes)Schistosoma mansoniBlood fluke/ intestinal schistosomiasis Human39012599206Draft completedSI/TIGRS. haematobiumBlood fluke/urinary schistosomiasisHuman—126160In
intestinal schistosomiasis 14456 completedSI/TIGRS. haematobiumBlood fluke/urinary schistosomiasisHuman—126160In progressSIS. japonicumBlood fluke/ intestinal schistosomiasis Human40029491104Draft completedCNHGCClonorchis sinensisLiver fluke/clonorchiasisHuman—179753In progressSNUCMaWUGC,
malaria 2555 pregnancy, and productivity—rivals that of the main high-mortality conditions such as HIV/AIDS or malaria [1]. For example, based on a recent analysis [2], 85% of the neglected tropical disease (NTD) burden
malaria 3584 for total helminth infections in SSA is 5.4–18.3 million in comparison to 40.9 million DALYs for malaria and 9.3 million DALYs for tuberculosis. Yet, research into helminth infections has not received nearly
necatoriasis 12897 sGenome Sequencing StatusSequencing InstituteaNematoda (roundworms)Clade VbNecator americanusHookworm/ necatoriasis Human—203695In progressWUGCAncylostoma caninumModel hookwormDog3441284181Improving draftWUGCNippostrongylus
onchocerciasis 3236 with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease representing a significant cause of disability
schistosomiasis 3095 the second most prevalent NTD after hookworm, accounting for 93% of the world's number of cases of schistosomiasis and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46–51
schistosomiasis 5321 eggs trapped in the intestines, liver, and other organs of the infected person are the cause of the schistosomiasis pathology and morbidity. (F) A pair of adult worms of the blood fluke Schistosoma mansoni; the more
schistosomiasis 7561 outbreaks are reported routinely in response to environmental and sociopolitical changes [3]. For example, schistosomiasis has reemerged many times in Africa in recent times in response to hydrological changes, e.g. construction
schistosomiasis 14303 tapeworm/taeniasis/cysticercosisHuman2701781525Draft completedMexico CityTrematoda (flukes)Schistosoma mansoniBlood fluke/intestinal schistosomiasis Human39012599206Draft completedSI/TIGRS. haematobiumBlood fluke/urinary schistosomiasisHuman—126160In
schistosomiasis 14390 fluke/intestinal schistosomiasisHuman39012599206Draft completedSI/TIGRS. haematobiumBlood fluke/urinary schistosomiasis Human—126160In progressSIS. japonicumBlood fluke/intestinal schistosomiasisHuman40029491104Draft completedCNHGCClonorchis
schistosomiasis 14467 haematobiumBlood fluke/urinary schistosomiasisHuman—126160In progressSIS. japonicumBlood fluke/intestinal schistosomiasis Human40029491104Draft completedCNHGCClonorchis sinensisLiver fluke/clonorchiasisHuman—179753In progressSNUCMaWUGC,
strongyloidiasis 13117 draftWUGCNippostrongylus brasiliensisModel hookwormRat—2044514.7In progressSIClade IVStrongyloides stercoralisThreadworm/ strongyloidiasis Human——11.4In progressSIS. rattiModel threadwormRat——27.4In progressSI/WUGCClade IIIAscaris lumbricoidesLarge
taeniasis 14179 granulosusTapeworm/unilocular hydatidosisCanids; larva infects humans1501262010In progressSITaenia soliumPork tapeworm/ taeniasis /cysticercosisHuman2701781525Draft completedMexico CityTrematoda (flukes)Schistosoma mansoniBlood fluke/intestinal
trichinosis 13726 progressSIAcanthocheilonema viteaeModel filariaRodent—332390In progressUMIGSClade ITrichinella spiralisTrichina worm/ trichinosis Pig to human711260525.3Draft completedWUGCTrichuris trichiuraWhipworm/trichuriasisHuman——0In progressSIT.
trichuriasis 13807 spiralisTrichina worm/trichinosisPig to human711260525.3Draft completedWUGCTrichuris trichiuraWhipworm/ trichuriasis Human——0In progressSIT. murisModel whipwormMouse96—7In progressSIT. suisModel whipwormPig-—0In
tuberculosis 3618 SSA is 5.4–18.3 million in comparison to 40.9 million DALYs for malaria and 9.3 million DALYs for tuberculosis . Yet, research into helminth infections has not received nearly the same level of support. This is partly
urinary schistosomiasis 14382 mansoniBlood fluke/intestinal schistosomiasisHuman39012599206Draft completedSI/TIGRS. haematobiumBlood fluke/ urinary schistosomiasis Human—126160In progressSIS. japonicumBlood fluke/intestinal schistosomiasisHuman40029491104Draft completedCNHGCClonorchis

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