Clinical and Molecular Features of Thiazide-Induced Hyponatremia.

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Annotation Summary

Term Occurence Count Dictionary
hypothyroidism 1 endocrinologydiseases
sodium chloride 4 endocrinologydiseasesdrugs
tolvaptan 1 endocrinologydiseasesdrugs
Gitelman syndrome 1 endocrinologydiseases
Hyponatremia 2 endocrinologydiseases
amiloride 2 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
amiloride 3509 from tubular filtrate in the distal nephron has a marked effect on blood pressure and although the amiloride -sensitive epithelial sodium (Na) channel (ENaC) has classically dominated research interest; Na-Cl reabsorption
amiloride 12437 age-matched elderly controls (open circles) with a single oral dose of hydrochlorothiazide 50 mg plus amiloride 5 mg. Serum sodium fell within 6 h in TIH patients only (a) (*P < 0.01) and this was accompanied
sodium chloride 3005 effects from antihypertensive treatment.The association of hypertension with salt is intriguing however; sodium chloride intake correlates with the prevalence of hypertension even in disparate populations [[]], and sodium
sodium chloride 3658 channel (ENaC) has classically dominated research interest; Na-Cl reabsorption via the thiazide-sensitive sodium chloride co-transporter, NCC, is at least as important [[]].Thiazide and thiazide-like diuretics share a common
sodium chloride 3901 the distal convoluted tubule of the nephron by binding to the luminal side of the thiazide-sensitive sodium chloride co-transporter, NCC. NCC is responsible for around 5–7% of renal sodium reabsorption [[]]. Commonly
sodium chloride 16003 vitamin D relative to normonatremic controls. It is possible that the lower concentration of the non- sodium chloride electrolytes could represent a dilution of blood from water retention, and this was supported by increased
tolvaptan 22878 restriction, parenteral infusion of normo- or hyper-tonic saline and the use of V2 antagonists such as tolvaptan ) were found to be associated with increased probability of overly rapid correction of serum sodium [[]].
Select Disease Character Offset Disease Term Instance
Gitelman syndrome 18689 effects of thiazides contributing to TIH may be argued from the absence of significant hyponatremia in Gitelman syndrome [[]] or Gitelman-mimic animals carrying a loss of function mutation in the NCC regulator Ste20 Proline-Alanine-rich
Hyponatremia 87 Title: Current Hypertension ReportsClinical and Molecular Features of Thiazide-Induced Hyponatremia Jodie NadalSarath K. ChannavajjhalaWenjing JiaJenny ClaytonIan P. HallMark GloverPublication date (epub):
Hyponatremia 12706 (b) (**P < 0.01). Reproduced with permission from Eitan Friedman, MD, et al., Thiazide-Induced Hyponatremia : Reproducibility by Single Dose Rechallenge and an Analysis of Pathogenesis. Annals of Internal Medicine,
diabetes mellitus 9964 identified by systematic review and meta-analysis were cardiovascular disease (49%, 95% CI 33 to 65%) and diabetes mellitus (27%, 95% CI 14 to 42%) although there was substantial heterogeneity between studies which was not explained
diabetes mellitus 10257 [[]••]. The 2017 case series of TIH patients broadly agreed with this having 17% of patients with treated diabetes mellitus , 19% with moderate renal impairment (eGFR 30–60 mL/min), and 6% with treated hypothyroidism [[]••].The
hypothyroidism 10355 treated diabetes mellitus, 19% with moderate renal impairment (eGFR 30–60 mL/min), and 6% with treated hypothyroidism [[]••].The commonest polypharmacy reported in the systematic review of TIH includes angiotensin

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