Progress in Metabonomics of Type 2 Diabetes Mellitus

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 1 endocrinologydiseases
hyperglycemia 3 endocrinologydiseases
metformin 2 endocrinologydiseasesdrugs
obesity 4 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
metformin 3904 theoretical basis for the pathogenesis of T2DM. Metabonomics has also been used to explore the effects of metformin on metabolites in T2DM patients and to explore the metformin’s metabolic mechanism of a hypoglycemic
metformin 3965 also been used to explore the effects of metformin on metabolites in T2DM patients and to explore the metformin ’s metabolic mechanism of a hypoglycemic effect [[5]]. To fully understand the pathological mechanisms
Select Disease Character Offset Disease Term Instance
diabetes mellitus 888 7/2018AbstractWith the improvement of living standards and a change in lifestyle, the incidence of type 2 diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely understand yet. Metabonomics techniques
hyperglycemia 24188 metabolomic analysis of fatty acids in the serum of healthy subjects, T2DM patients, and postprandial hyperglycemia patients. The results showed that palmitic acid, stearic acid, oleic acid, linolenic acid, and linolenic
hyperglycemia 30117 serum 1,5-AG. Dungan et al. [[84],[85],[86]] found that 1,5-AG is a sensitive indicator of postprandial hyperglycemia [[87],[88],[89]] and many patients who are well-controlled by the glycemic control index HBc also have
hyperglycemia 30259 patients who are well-controlled by the glycemic control index HBc also have significant postprandial hyperglycemia [[90]].In the above studies about metabolites in patients with T2DM, the trends of biomarkers detected
obesity 7449 is often observed in T2DM [[16]].2.5. ObesityMost patients with T2DM are obese especially centrally obesity , which is mainly characterized by abnormal glucose and lipid metabolism. There is a significant negative
obesity 7655 negative correlation between the abdominal fat area and insulin-mediated glucose utilization. Central obesity patients have increased abdominal fat, metabolic disorders in visceral adipose tissue (VAT) and impaired
obesity 8261 [[19]]. The main feature of T2DM is the decrease of insulin sensitivity. The main causes of T2DM are obesity , oxidative stress, gene and aging, insulin resistance occurs first. The increase of visceral fat leads
obesity 16966 diabetes [[34],[35],[36]]. Newgard et al. [[37]] found that BCAA contributes to the development of obesity -related IR. A metabolomic study of 74 obese subjects and 67 lean subjects showed that isoleucine, leucine,
type 2 diabetes mellitus 881 7/2018AbstractWith the improvement of living standards and a change in lifestyle, the incidence of type 2 diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely understand yet. Metabonomics techniques

You must be authorized to submit a review.