Flavonoids, Potential Bioactive Compounds, and Non-Shivering Thermogenesis

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Term Occurence Count Dictionary
17β-estradiol 1 endocrinologydiseasesdrugs
dexamethasone 1 endocrinologydiseasesdrugs
obesity 15 endocrinologydiseases
polycystic ovary syndrome 2 endocrinologydiseases
rosiglitazone 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
17β-estradiol 37886 regulation of energy balance. Postmenopausal women and ovariectomized mice showed decreased levels of 17β-estradiol (E2), a major estrogen that is associated with weight gain and increased fat content in the body [[102]].
dexamethasone 13509 differentiate into beige-like adipocytes through prolonged treatment with beige induction cocktails ( dexamethasone , 3-isobutyl-1-methylxanthine, insulin, triiodothyronine, and rosiglitazone), and partly through the
rosiglitazone 13584 beige induction cocktails (dexamethasone, 3-isobutyl-1-methylxanthine, insulin, triiodothyronine, and rosiglitazone ), and partly through the manipulation of C/EBPβ [[40],[41]]. As part of the beige cocktail treatment,
Select Disease Character Offset Disease Term Instance
obesity 1224 increasing interest in understanding the mechanism by which plant-derived dietary compounds prevent obesity , flavonoids were recently shown to have the potential to regulate non-shivering thermogenesis. In this
obesity 1580 IntroductionObesity is a growing health problem worldwide [[1]]. Excessive body fat, which is referred to as obesity , impairs normal metabolic regulation, which increases risk factors for the development of other metabolic
obesity 1899 [[1]]. Given its seriousness as a health issue, various strategies have attempted to prevent and reduce obesity such as diet programs, surgery, and medications. However, these current strategies have limitations
obesity 2177 appropriateness for certain age ranges. Consequently, there remains a need to discover new methods to control obesity . One new way to regulate fat accumulation is to activate the non-shivering thermogenesis function of
obesity 2722 re-evaluated as a potential tissue for the prevention and improvement of metabolic diseases, such as obesity , diabetes, and cardiovascular diseases [[4],[5],[6],[7]].Brown adipocytes are derived from the same
obesity 9946 flavonoid has specific health benefits; many phytochemicals that are classified as flavonoids exert an anti- obesity effect by regulating the oxidation, synthesis, uptake, and transport of fatty acids [[27]]. Individuals
obesity 10100 uptake, and transport of fatty acids [[27]]. Individuals with a higher flavonoid intake show lower obesity indicators, e.g., a lower body mass index, and decreased levels of C-reactive protein, a marker of inflammation
obesity 19195 which is the most abundantly consumed flavonol. Onion peel extract (OPE) and quercetin exerted anti- obesity effects by inhibiting adipogenesis and lipogenesis [[52],[53]]. In an in vitro study using 3T3-L1 cells,
obesity 21431 adipocyte-specific genes in the BAT and WAT of both ob/ob and C57Bl/6J mice with HFD (60% calories from fat)-induced obesity [[57]]. To promote non-shivering thermogenesis in BAT and WAT, the expression of genes involved in the
obesity 24187 reduced the body weight and fat mass of db/db mice and improved the plasma lipid profile and other obesity -related metabolic alterations, such as glucose tolerance, insulin resistance, and hepatic steatosis
obesity 27675 extract (20 g/kg diet) reversed HFD-reduced energy expenditure of Sprague-Dawley rats with HFD-induced obesity to the same level of energy expenditure as observed in rats fed a normal diet [[76]]. This effect was
obesity 32916 Pparα, Pgc1α, Sirt1, and Ucp1 genes, which caused browning effect on the RWAT of rats with HFD-induced obesity , but this upregulation was less effective than that induced individually by the flavanols epicatechin,
obesity 38460 [[104],[105],[106],[107],[108]]. The isoflavone-rich fraction of the Kudzu (Puerariae thomsonii) flower exerted anti- obesity effects by increasing lipolysis in WAT and Ucp1 expression in the BAT of mice with HFD-induced obesity
obesity 38563 anti-obesity effects by increasing lipolysis in WAT and Ucp1 expression in the BAT of mice with HFD-induced obesity [[104]]. Ucp1 mRNA expression was also significantly increased in the BAT of male Long-Evans rats administered
obesity 40290 and sterol regulatory element-binding protein 1 [[108]]. An in vivo study using mice with HFD-induced obesity also supported the anti-adipogenesis and browning effects of formononetin [[108]]. PPARγ and C/EBPα
polycystic ovary syndrome 22297 through BAT, the therapeutic potential of rutin was studied in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rats [[60]]. DHEA-induced PCOS rats showed decreased expression of BAT-specific genes and genes
polycystic ovary syndrome 51249 biogenesis and whole-body energy expenditure↑ BAT activity and SWAT browningYuan et al. [[57]]RutinFemale polycystic ovary syndrome SD-ratsRutin (100 mg/kg) indrinking water for 3 weeks↑ UCP1, Ucp1, Pparα, Pgc1α, Pgc1β, and Cpt1α

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