Egg and Soy-Derived Peptides and Hydrolysates: A Review of Their Physiological Actions against Diabetes and Obesity.

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Term Occurence Count Dictionary
metformin 2 endocrinologydiseasesdrugs
obesity 24 endocrinologydiseases
Insulin 8 endocrinologydiseasesdrugs
glucose intolerance 1 endocrinologydiseases
hyperglycemia 1 endocrinologydiseases
metabolic syndrome 5 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 32347 angiotensin converting enzyme; Ang-II, Angiotensin II; DPP IV, Dipeptidyl peptidase IV; EW, Egg white; IRS-1, Insulin receptor substrate 1; IRS, Insulin receptor; IRβ, Insulin receptor β; COX-2, cyclooxygenase 2; PPARγ,
Insulin 32382 Angiotensin II; DPP IV, Dipeptidyl peptidase IV; EW, Egg white; IRS-1, Insulin receptor substrate 1; IRS, Insulin receptor; IRβ, Insulin receptor β; COX-2, cyclooxygenase 2; PPARγ, peroxisome proliferator associated
Insulin 32406 Dipeptidyl peptidase IV; EW, Egg white; IRS-1, Insulin receptor substrate 1; IRS, Insulin receptor; IRβ, Insulin receptor β; COX-2, cyclooxygenase 2; PPARγ, peroxisome proliferator associated receptor gamma; C/EBP-α,
Insulin 43438 cells in vitro.N/AAbbreviations: SH, Soy hydrolysate; Ap2, adipocyte fatty acid-binding protein; IRS-1, Insulin receptor substrate 1; COX-2, Cyclooxygenase 2; PPARγ, Peroxisome proliferator associated receptor gamma;
Insulin 44879 administration.Glucose after 28 days ↓ by Aglycin.OGTT and ITT- Aglycin similar effect as metformin. Insulin release not affected during OGTT.Skeletal Muscle ↑ mRNA and total protein of IR and IRS-1. Total AKT
Insulin 48332 responded in a dose dependent manner. No effects in blood glucose were observed.N/AAbbreviations: IRS, Insulin receptor; IRS-1, Insulin receptor substrate 1; AKT, protein kinase B; GLUT4, Glucose transporter 4;
Insulin 48357 dependent manner. No effects in blood glucose were observed.N/AAbbreviations: IRS, Insulin receptor; IRS-1, Insulin receptor substrate 1; AKT, protein kinase B; GLUT4, Glucose transporter 4; SPIH, Soy hydrolysate; SP,
Insulin 48583 protein; HFD, High fat diet; CHOL-cholesterol; TG, Triglyceride; OGTT, Oral glucose tolerance test; ITT, Insulin tolerance test; T2D, Type 2 diabetes; BW, Body weight; BMI, Body mass index; WK, week; ↑ enhanced/stimulated;
metformin 23956 sensitivity in T2D mice [[27]]. In fact, treatment with aglycin led to similar results as those exerted by metformin in oral glucose tolerance (OGTT) and insulin tolerance tests [[27]]; furthermore, the release of insulin
metformin 44868 after oral administration.Glucose after 28 days ↓ by Aglycin.OGTT and ITT- Aglycin similar effect as metformin . Insulin release not affected during OGTT.Skeletal Muscle ↑ mRNA and total protein of IR and IRS-1.
Select Disease Character Offset Disease Term Instance
glucose intolerance 45088 AKT and GLUT 4 mRNA not different. ↑ p-IR, p-IRS-1, p-AKT and GLUT4 on membrane.Aglycin ameliorated glucose intolerance and insulin resistance in T2D mice mainly by ↑ glucose utilization and insulin sensitivity after long-term
hyperglycemia 1818 syndrome-related conditions.1. IntroductionDiabetes is a chronic disease marked by the presence of hyperglycemia that occurs when the pancreas cannot produce enough insulin, or the body cannot effectively use the
metabolic syndrome 540 (collection): 5/2018AbstractType 2 diabetes and obesity are two chronic conditions associated with the metabolic syndrome and their prevalences are increasing worldwide. The investigation of food protein-derived bioactive
metabolic syndrome 1325 bioactive peptides from egg and soy can potentially be used to manage elements of glucose homeostasis in metabolic syndrome ; however, the mechanisms of action on glucose and insulin metabolism, and the interaction between peptides
metabolic syndrome 1709 their effects on diabetes and obesity could help to clarify the effects of these bioactive peptides in metabolic syndrome -related conditions.1. IntroductionDiabetes is a chronic disease marked by the presence of hyperglycemia
metabolic syndrome 4066 inflammation and oxidative stress are observed in obesity and diabetes, which in turn are components of the metabolic syndrome (MetS) along with hypertension, it is of interest to study egg and soy in terms of their anti-diabetic
metabolic syndrome 30590 et al. 2016[[19]]264.7 RAW macrophagesInvestigate multiple biological properties of related to the metabolic syndrome AlcalaseFlavourzymeNeutraseTrypsinPepsinPancreatinPeptidasePromod 144P(0, 2, 4, 8, 12, 24, 36 and 48
obesity 485 CanadaPublication date (epub): 4/2018Publication date (collection): 5/2018AbstractType 2 diabetes and obesity are two chronic conditions associated with the metabolic syndrome and their prevalences are increasing
obesity 720 investigation of food protein-derived bioactive peptides that can improve the pathophysiology of diabetes or obesity while causing minimal side effects is desired. Egg and soy proteins generate bioactive peptides with
obesity 957 exerting nutritional and physiological benefits. This review focuses on the anti-diabetic and anti- obesity effects of egg- and soy-derived peptides and hydrolysates in vivo and in vitro relevant to these conditions.
obesity 1636 soy-derived peptides and standardizing the physiological models to study their effects on diabetes and obesity could help to clarify the effects of these bioactive peptides in metabolic syndrome-related conditions.1.
obesity 4008 [[6]]. Since an upregulated renin angiotensin system, inflammation and oxidative stress are observed in obesity and diabetes, which in turn are components of the metabolic syndrome (MetS) along with hypertension,
obesity 4197 with hypertension, it is of interest to study egg and soy in terms of their anti-diabetic and anti- obesity properties.This review focuses on the effects of EH and soy hydrolysate (SH) or peptides in improving
obesity 4347 effects of EH and soy hydrolysate (SH) or peptides in improving or preventing type 2 diabetes (T2D) and obesity in vivo or relevant in vitro endpoints such as insulin signaling pathways. The inclusion criteria were
obesity 8999 peptidase-mediated hydrolysis had the highest potential against disorders associated with MetS such as hypertension, obesity and T2D, presenting IC50 against DPP-IV of <10 mg protein/mL and against ACE ranging from 47 to 151
obesity 13882 unsaturated fatty acid [[12]]. The SCD index is the ratio between those fatty acids and is related to obesity and insulin resistance. Dietary supplementation with protease-prepared EWH decreased SCD index in serum,
obesity 16401 yet no evidence for this hypothesis.Anti-inflammatory and antioxidant activity can contribute towards obesity and diabetes management [[15]]. In two studies in vivo, treatment with pepsin- and alcalase-prepared
obesity 18950 peptides, and eight studies evaluating the in vitro effects of SH or peptides against diabetes and obesity are summarized in Table 3. Similarly to EH, during adipocyte differentiation SH obtained from pepsin
obesity 21950 terminal Arg358 residues [[11]].Inflammation is not the focus of this review, but it is linked with obesity and diabetes. Two studies reported changes in inflammatory markers by SH [[18]] or soy peptide [[30]]
obesity 26879 peptides; furthermore, they can potentially exert multiple physiological activities, including anti- obesity and anti-diabetic effects, which is relevant in the management of MetS. Bioactive peptides can be produced
obesity 27887 treatment length and the use of animals with different physiological and genetic backgrounds, such as obesity , diabetes and normal physiology contributed to the discrepancies in the results observed in vivo, which
obesity 28306 and soybean have overlapping biological activities that may be useful in the treatment of diabetes or obesity .A weak correlation between the studies mentioned in this review and clinical trials could be drawn.
obesity 29046 metabolism were found.Even though some investigation of the effects of EH and SH on markers of diabetes and obesity have been done, there is still a lack of studies with focus on the mechanisms of absorption and action
obesity 29464 and SH and their real potential as functional food ingredients to be implemented in the management of obesity and T2D.nutrients-10-00549-t001_Table 1Table 1In vitro studies of egg-derived hydrolysates/peptides
obesity 29614 1Table 1In vitro studies of egg-derived hydrolysates/peptides and their effects related to diabetes and obesity .AimsHydrolysisMain FindingsAdditional AssaysPeptidesEgg yolk specific peptidesEnzymatic activityZambrowicz
obesity 33062 2Table 2In vivo studies of egg-derived hydrolysates/peptides and their effects related to diabetes and obesity in rodents.AimsHydrolysisTreatment DetailsFood Intake and Body Weight (BW)Blood/Feces/Urine AnalysisTissue
obesity 35723 in muscle.Garcés-Rimon et al., 2016[[14]]Zucker obese ratsDemonstrate the effects of EWH related to obesity , lipid metabolism, inflammation and oxidative stressPepsin(8 or 14 h)Aqueous EWH(750 mg/kg/day)12 weeksNo
obesity 38462 3In vitro studies of soy-derived hydrolysates (SH)/peptides and their effects related to diabetes and obesity .AimsHydrolysisOutcomesMain FindingsPeptidesSoy specific peptidesEnzymatic activityLammi et al., 2016[[11]]Verify
obesity 40637 mainly through PepT2 action and FLV can ↓ the inflammatory and insulin resistant states linked to obesity mainly by ↓ TNF-α induced inflammatory pathways.FLVSoy HydrolysateCell cultureMartinez-Villaluenga
obesity 44304 4Table 4In vivo studies of soy-derived hydrolysates/peptides and their effects related to diabetes and obesity .AimsHydrolysisTreatment DetailsFood Intake and Body Weight (BW)Blood/Feces/Urine AnalysisTissue AnalysisMain
obesity 46393 mice.Aoyama et al., 2000[[34]]Yellow KK miceStudy the effect of intact soy protein and hydrolysate as anti- obesity agentsProtease (duration not specified)HFD for 4 weeks + SPI or SPIH or WI or WIH for 2 weeks (energy

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