Calcific Aortic Valve Disease: a Developmental Biology Perspective.

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Annotation Summary

Term Occurence Count Dictionary
dexamethasone 1 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
hyperphosphatemia 1 endocrinologydiseases
vascular calcification 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
dexamethasone 21474 well-established protocol involves culturing VICs in osteogenic media (ascorbic acid, β-glycerophosphate, and dexamethasone ) to stimulate calcific nodule formation. In addition, others have supplemented media with inorganic
Select Disease Character Offset Disease Term Instance
diabetes mellitus 2733 (LDL) triglycerides, decreased high-density lipoproteins, male sex, tobacco use, hypertension, and diabetes mellitus have been reported to increase the incidence of aortic stenosis [[], []]. It is not yet clear how these
hyperphosphatemia 21636 addition, others have supplemented media with inorganic phosphate (sodium phosphate dibasic), mimicking hyperphosphatemia in chronic kidney disease largely associated with increased CAVD [[], []]. We and others have shown
vascular calcification 19236 progression [[]]. Many of these factors are thought to be shared with atherosclerotic plaque formation and vascular calcification ; however, parallels in pathogenic mechanisms remain elusive but warrant further investigation. At present,

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