Role of carnitine and its derivatives in the development and management of type 2 diabetes.

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Term Occurence Count Dictionary
obesity 3 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
diabetic neuropathy 2 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
hyperlipidemia 3 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 27185 increased long-chain acylcarnitine concentrations and elevated levels of free carnitine were detected. Insulin infusion resulted in a significant decrease in every acylcarnitine species between carbon lengths from
Select Disease Character Offset Disease Term Instance
diabetes mellitus 17314 study3 g LCOral4 weeksFPG↔HbA1c↔GUR↔TG↔LDL-C↔HDL-C↔TC↔[33]NIDDM non-insulin-dependent diabetes mellitus , T2D type 2 diabetes, EHC euglycemic hyperinsulinemic clamp, IC indirect calorimetry, FPG fasting plasma
diabetes mellitus 26027 from diabetes patients were examined using ESI/MS by Möder et al., and as a result they observed that diabetes mellitus patients excrete more long-chain acylcarnitines (C12-C16) than the controls, supposedly caused by a
diabetic neuropathy 23501 in diabetes. De Grandis et al. investigated the efficacy and tolerability of ALC in the treatment of diabetic neuropathy over a 1-year period, focusing on the effects of the treatment on electrophysiological parameters and
diabetic neuropathy 23984 particularly pain, and improves nerve fiber regeneration and vibration perception in patients with established diabetic neuropathy [47]. Clinical trials of ALC administration in type 2 diabetic polyneuropathy have shown beneficial effects
glucose intolerance 28014 branched-chain amino acid catabolic flux may increase gluconeogenesis and may be involved in the development of glucose intolerance via glutamate transamination to alanine[55]. Zhang et al. investigated the serum acylcarnitine profiles
hyperglycemia 347 (collection): /2018AbstractType 2 diabetes is a highly prevalent chronic metabolic disorder characterized by hyperglycemia and associated with several complications such as retinopathy, hyperlipidemia and polyneuropathy. The
hyperglycemia 19416 its derivatives in diabetes complicationsOne of the characteristic hallmarks of T2D is the chronic hyperglycemia . Uncontrolled elevated blood glucose level is supposed to be associated with the development of severe,
hyperlipidemia 424 disorder characterized by hyperglycemia and associated with several complications such as retinopathy, hyperlipidemia and polyneuropathy. The dysregulated fatty acid metabolism along with tissue lipid accumulation is generally
hyperlipidemia 20725 However, the free carnitine levels were not significantly different between the groups with retinopathy, hyperlipidemia and polyneuropathy. Furthermore, they did not observe a significant relationship between serum free
hyperlipidemia 21226 complications. While the levels of total and free carnitines were lower in the patient group with retinopathy, hyperlipidemia and polyneuropathy compared to T2D patients with no complications, there were no significant differences
metabolic syndrome 30211 C18:2↓,SCAC↑, MCAC↓, LCAC ↔ n.m.[53]T2D type 2 diabetes, DM diabetes, T1D type 1 diabetes, MetS metabolic syndrome , FPG fasting plasma glucose, FINS fasting insulin, HbA1c hemoglobin A1c, FFA free fatty acid, TG triglyceride,
metabolic syndrome 30733 research group investigated the circulating acylcarnitine profiles in type 1 Diabetes, type 2 Diabetes and metabolic syndrome patients conjecturing in which carnitine homeostasis may likely possess similarities in these metabolic
obesity 18198 carnitine supplementation improves glucose tolerance during insulin- resistant states, such as diabetes or obesity [38].Several mechanisms have been suggested in support of the favorable effect of carnitine on glucose
obesity 26647 in T2D African-American women[54]. Plasma acylcarnitine profiles were characterized in patients with obesity and T2D during fasting and insulin-stimulated conditions in Mihalik’s study[27] to find out the site
obesity 26828 study[27] to find out the site of derangements in FAO and electron transport chain (ETC) activity in obesity and T2D. T2D patients presented increased levels of short- and medium-chain acylcarnitines, both saturated

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