A Review on the Protective Effects of Honey against Metabolic Syndrome

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
acarbose 2 endocrinologydiseasesdrugs
allopurinol 2 endocrinologydiseasesdrugs
hyperglycemia 2 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases
obesity 13 endocrinologydiseases
diabetes mellitus 8 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
hyperlipidemia 2 endocrinologydiseases
hyperuricemia 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
acarbose 19795 properties compared to other multifloral honey species. This was comparable to standard diabetic therapy by acarbose especially at the highest concentration of 500 μg/mL. Furthermore, raw T. iridipennis honey had the
acarbose 43305 multifloral honey species. Inhibition of α-amylase enzyme was comparable to standard diabetic therapy by acarbose especially the highest concentration of 500 μg/mL.DM, diabetes mellitus; FBS, fasting blood sugar;
allopurinol 34021 capacity) as compared to the control group. These fructose-induced changes were successfully reversed by allopurinol treatment (an XO inhibitor) at 5 mg/kg/day. Apart from that, fructose-fed rats also had significantly
allopurinol 34338 histological analysis, and hepatic fat accumulation compared to control rats which were also reduced by allopurinol administration [[103]]. This corroborated with a study which showed male rats fed with 20-25% fructose
Select Disease Character Offset Disease Term Instance
diabetes mellitus 944 (collection): 8/2018AbstractMetabolic syndrome (MetS) is a cluster of diseases comprising of obesity, diabetes mellitus , dyslipidemia, and hypertension. There are numerous pre-clinical as well as human studies reporting
diabetes mellitus 4493 Additionally, chronic medical conditions and genetic predisposition to obesity, insulin resistance, diabetes mellitus , high blood pressure and hyperlipidemia also predispose an individual to MetS [[9]].Lifestyle modification
diabetes mellitus 12013 BMI (1.2%; p = 0.02) [[33]]. In another RCT, Bahrami et al. (2009) recruited 42 patients with type II diabetes mellitus and randomly assigned them into control and honey-supplemented groups for 56 days. This study reported
diabetes mellitus 12473 Individuals with metabolic syndrome had a five-fold increased risk for developing the disease [[1]]. Type II diabetes mellitus is a chronic noncommunicable disease characterized by insulin insensitivity causing a rise in the blood
diabetes mellitus 24084 Another animal study reported that Nigerian honey administration for 21 days to rats with alloxan-induced diabetes mellitus produced a significant reduction of TG, non-HDL cholesterol especially VLDL, cardiovascular risk index
diabetes mellitus 39285 patients as compared to control (69.5 ± 11.9 kg vs. 70.3 ± 8.0 kg; p = 0.000).BMI, body mass index; DM, diabetes mellitus .nutrients-10-01009-t002_Table 2Table 2Anti-diabetic effects of honey in clinical and pre-clinical studies.AuthorHoney
diabetes mellitus 43369 comparable to standard diabetic therapy by acarbose especially the highest concentration of 500 μg/mL.DM, diabetes mellitus ; FBS, fasting blood sugar; IQR, interquartile range.nutrients-10-01009-t003_Table 3Table 3Hypolipidemic
diabetes mellitus 50262 baseline value (110.20 ± 2.14 mmHg, 111.33 ± 2.14 mmHg, 110.4 ± 2.08 mmHg vs. 117.80 ± 0.88 mmHg) DM, diabetes mellitus ; H2O2, hydrogen peroxide; HUVEC, human umbilical vein endothelial cells; SBP, systolic blood pressure;
hyperglycemia 2919 five conditions which include: (1) Fasting serum glucose ≥100 mg/dL (or receiving drug therapy for hyperglycemia ); (2) Blood pressure ≥130/85 mmHg (or receiving medical therapy for hypertension); (3) Serum triglycerides
hyperglycemia 35226 peroxiredoxin I enzymes, along with the stimulation of inflammatory processes. These changes resulted in hyperglycemia , hypercholesterolemia and hypertension in the fructose-fed rats compared to control [[105]].Conversely,
hyperinsulinemia 26912 obese individuals have insulin resistance with a compensatory increase in insulin secretion, leading to hyperinsulinemia . As a consequence, there will be activation of the sympathetic nervous system (SNS), through stimulation
hyperlipidemia 4536 and genetic predisposition to obesity, insulin resistance, diabetes mellitus, high blood pressure and hyperlipidemia also predispose an individual to MetS [[9]].Lifestyle modification remains the main emphasis of MetS
hyperlipidemia 23376 lipid profile parameters was less pronounced [[70]]. Findings from the animal experimental model of hyperlipidemia were found to complement the hypolipidemic properties of honey in human subjects. By using STZ-induced
hypertriglyceridemia 3092 therapy for hypertension); (3) Serum triglycerides (TG) ≥ 150 mg/dL (or receiving drug therapy for hypertriglyceridemia ); (4) Serum high-density lipoprotein cholesterol (HDL-C) < 40 mg/dL in men or <50 mg/dL in women (or
hyperuricemia 32702 meta-analyses reported that there was close association between fructose consumption and development of future hyperuricemia that may be explained by increased purine nucleotides production as well as their catabolism [[100]].
metabolic syndrome 12381 period [[34]].3. Antidiabetic EffectsMetS is predictive of type II diabetes [[35]]. Individuals with metabolic syndrome had a five-fold increased risk for developing the disease [[1]]. Type II diabetes mellitus is a chronic
obesity 935 8/2018Publication date (collection): 8/2018AbstractMetabolic syndrome (MetS) is a cluster of diseases comprising of obesity , diabetes mellitus, dyslipidemia, and hypertension. There are numerous pre-clinical as well as human
obesity 4384 diet consisting of high saturated fat with low fibre, as well as general and central (or abdominal) obesity . Additionally, chronic medical conditions and genetic predisposition to obesity, insulin resistance,
obesity 4464 central (or abdominal) obesity. Additionally, chronic medical conditions and genetic predisposition to obesity , insulin resistance, diabetes mellitus, high blood pressure and hyperlipidemia also predispose an individual
obesity 5835 anti-oxidant, anti-inflammatory, pancreatoprotective, anti-hypertensive, hepatoprotective and anti- obesity properties [[12],[13],[14],[15],[16]].According to the Codex Alimentarius, “honey is the natural sweet
obesity 9070 out of five criteria in an individual is required for diagnosing MetS. One of the criteria is central obesity due to the accumulation of visceral adipose, defined by increased waist circumference [[1]]. As excessive,
obesity 9768 infiltration leading to the manifestation of other MetS components.Protective effects of honey against obesity have been reported in animal experimental studies (Table 1). For instance, short-term feeding with honeydew
obesity 11030 fatty degeneration which were significantly reduced in the honey supplemented group [[32]]. The anti- obesity effect of honey was further demonstrated by Nemoseck et al. (2011). In this experiment, the researchers
obesity 11430 isoenergetic diet from liquid sucrose [[16]].It is noteworthy that honey is also capable of exerting anti- obesity effects in human as reported in randomized clinical trials (RCTs). A total number of 55 apparently healthy,
obesity 26600 MetS. There are many factors that contribute to the development of hypertension and one of them is obesity -related hypertension [[75]]. Blood pressure is regulated by the autonomic nervous system by means of
obesity 27473 has also been reported to stimulate SNS, thus contributing to elevated blood pressure associated with obesity [[80]]. Another mechanism by which leptin increases blood pressure is through the regulation of neuronal
obesity 27668 regulation of neuronal circuits in the dorsomedial hypothalamus (DMH). A study conducted in diet-induced obesity in mice found that injection with leptin receptor antagonist at the DMH for 7 days resulted in a significant
obesity 36126 unlikely caused by its fructose contents.7. ConclusionsHoney protects against MetS by exerting anti- obesity , antidiabetic, hypolipidemic and hypotensive activities. The mechanisms underlying these effects include
obesity 36731 management of MetS as a preventive and adjunct therapeutic agent.nutrients-10-01009-t001_Table 1Table 1Anti- obesity effects of honey in clinical and pre-clinical studies.AuthorHoney Sources/TypesDoseDurationModelsResultsNemoseck

You must be authorized to submit a review.