The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis.

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osteoporosis 38 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases
metabolic bone disease 1 endocrinologydiseases
obesity 1 endocrinologydiseases

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diabetes mellitus 17638 of several diseases, such as cancer [[59]], cardiovascular diseases [[60],[61]], obesity [[62]], and diabetes mellitus [[63]]. Recent studies demonstrated that serum miRNA levels were markedly up-regulated in patients with
metabolic bone disease 3137 formation and bone resorption [[8]]. An imbalance of bone formation and bone resorption can result in metabolic bone disease s. If the process of bone resorption is faster than new bone formation, osteoporosis can finally occur
obesity 17618 treatment and prognosis of several diseases, such as cancer [[59]], cardiovascular diseases [[60],[61]], obesity [[62]], and diabetes mellitus [[63]]. Recent studies demonstrated that serum miRNA levels were markedly
osteoporosis 112 Bioscience ReportsThe emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis Qianyun FengSheng ZhengJia ZhengPublication date (epreprint): 5/2018Publication date (collection): 6/2018Publication
osteoporosis 399 multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications
osteoporosis 615 may be the underlying mechanisms that link genetic and environmental factors with increased risks of osteoporosis and bone fracture. MicroRNA (miRNA), a major category of small noncoding RNA with 20–22 bases in length,
osteoporosis 1005 review, we aimed to profile the role of miRNA in bone remodeling and its therapeutic implications for osteoporosis . A deeper insight into the role of miRNA in bone remodeling and osteoporosis can provide unique opportunities
osteoporosis 1082 therapeutic implications for osteoporosis. A deeper insight into the role of miRNA in bone remodeling and osteoporosis can provide unique opportunities to develop a novel diagnostic and therapeutic approach of osteoporosis.IntroductionEpidemiology
osteoporosis 1186 osteoporosis can provide unique opportunities to develop a novel diagnostic and therapeutic approach of osteoporosis .IntroductionEpidemiology of osteoporosis and bone fractureOsteoporosis, a common and complex disease,
osteoporosis 1227 to develop a novel diagnostic and therapeutic approach of osteoporosis.IntroductionEpidemiology of osteoporosis and bone fractureOsteoporosis, a common and complex disease, is increasing dramatically with the aging
osteoporosis 1738 strong influence on life quality, morbidity, and even mortality. It is estimated that the prevalence of osteoporosis is in more than 75 million people worldwide, and the number will increase to approximately 14 million
osteoporosis 2384 additional vertebral fractures by 5 to 10 times [[6]]. In the United States, direct healthcare costs of osteoporosis and its related bone fractures are estimated to be 19 billion USD per year [[7]]. However, as a global
osteoporosis 2632 remains severely underprevented, underdiagnosed, and undertreated.Bone remodeling and pathogenesis of osteoporosis The skeleton microstructure is composed of mineralized extracellular matrix and bone remodeling units,
osteoporosis 3231 result in metabolic bone diseases. If the process of bone resorption is faster than new bone formation, osteoporosis can finally occur [[9]]. Osteoporosis is a multifactorial disease that can be regulated by both genetic
osteoporosis 3454 factors and environments. Using genome-wide association studies, numerous studies about genetic risks for osteoporosis have been performed to assess bone mineral density (BMD) as a quantitative trait [[10]]. It reported
osteoporosis 3637 quantitative trait [[10]]. It reported that more than 60 genes were related with BMD and the development of osteoporosis [[11]]. Several studies have identified a number of single nucleotide polymorphisms associated with
osteoporosis 4054 genetic causes of monogenic bone disorders with abnormal high or low bone mass and strength can induce osteoporosis [[16]]. Although genetic factors are important for the development of osteoporosis and other bone diseases,
osteoporosis 4137 strength can induce osteoporosis [[16]]. Although genetic factors are important for the development of osteoporosis and other bone diseases, it is reported that the power of genetic variables in bone remodeling is less
osteoporosis 4505 nutrients (including dietary calcium intake and vitamin D deficiency) are critical determinants of osteoporosis and bone fracture [[4]]. Recently, emerging evidence suggests that epigenetic modifications may be the
osteoporosis 4711 may be the underlying mechanisms that link genetic and environmental factors with an altered risk of osteoporosis [[18],[19]]. A hypothetical model was tentatively proposed to illustrate the interactions among genetic
osteoporosis 4960 epigenetics, and the potential mechanism underlying the role of microRNAs (miRNAs) in bone remodeling and osteoporosis (Figure 1). A deeper insight into the epigenetic mechanisms underlying bone remodeling will provide
osteoporosis 5131 mechanisms underlying bone remodeling will provide opportunities to develop a novel therapeutic approach for osteoporosis and bone fracture.Figure 1Epigenetic modifications underlying the risks of osteoporosis and bone fractureOsteoporosis
osteoporosis 5219 approach for osteoporosis and bone fracture.Figure 1Epigenetic modifications underlying the risks of osteoporosis and bone fractureOsteoporosis is a common and complex disease with multifactorial origin that is influenced
osteoporosis 5499 especially miRNAs represent a promising area to link genetics and gene expressions with the risks of osteoporosis and bone fracture; ALP, alkaline phosphatase; COL1A1, collagen, type I, α 1; CTR, calcitonin receptor;
osteoporosis 7410 circular RNA [[26]]. In our review, we mainly focused on the emerging role of miRNAs in bone remodeling, osteoporosis , and bone fracture.A glimpse at miRNAsMiRNAs are the most studied noncoding RNAs related with bone metabolism
osteoporosis 8499 [[26]]. Numerous evidence demonstrated that miRNAs can regulate bone remodeling and the development of osteoporosis and bone fracture [[33]].miRNA and its role in the process of bone remodelingmiRNAs and osteoblast differentiationIn
osteoporosis 10789 signaling and then inhibited bone formation [[45]]. Dickkopf-1 (DKK1), as an important biomarker for osteoporosis , is an antagonist of WNT signaling pathway. One recent study showed that miRNA-433-3p promoted osteoblast
osteoporosis 17256 transducer and activator of transcription 3; TGFβ1, transforming growth factor β1.Circulating miRNAs in osteoporosis and bone fractureIt reported that miRNAs can be secreted by different cells and have been discovered
osteoporosis 18005 miR-21, miR-125b, miR-100, and miR-148a were significantly increased in the serum of 30 patients with osteoporosis , compared with 30 nonosteoporotic controls [[64]]. Li et al. [65]] detected three miRNAs (miR-133a,
osteoporosis 18274 postmenopausal women and found that plasma miR-21 was decreased and miR-133a was increased in patients with osteoporosis and osteopenia, compared with the normal group according to T-scores of BMD. Weilner et al. [[66]] aimed
osteoporosis 19129 biomarkers in bone fracture. MiR-148a was reported to be increased in plasma in postmenopausal women with osteoporosis , and serum miR-148a level was correlated with clinical parameters of bone quality and quantity [[67]].
osteoporosis 20009 samples and longer follow-up are warranted to investigate the significance of circulating miRNAs in osteoporosis and bone frature.MiRNAs and its therapeutic implications for osteoporosisGenerally, it was deemed that
osteoporosis 20083 of circulating miRNAs in osteoporosis and bone frature.MiRNAs and its therapeutic implications for osteoporosis Generally, it was deemed that the process of epigenetic regulation was static. However, this viewpoint
osteoporosis 21106 diabetes [[73]]. Some preliminary studies have showed that miRNAs play a critical role in the treatment of osteoporosis and bone fracture. Resveratrol, as a polyphenolic phytoestrogen with osteoinductive and osteogenic properties,
osteoporosis 21244 Resveratrol, as a polyphenolic phytoestrogen with osteoinductive and osteogenic properties, could prevent osteoporosis in ovariectomized rats by suppressing the expression of miR-338-3p and increasing the expression of
osteoporosis 21546 suppression in MC3T3-E1 cells by targeting histone deacetylase 4 (HDAC4) [[75]]. In a glucocorticoid-induced osteoporosis C57BL/6J mice model, Li et al. [[76]] showed that curcumin improved bone microarchitecture by activating
osteoporosis 21828 two studies both suggest that miR-365 may be an important molecular regulating glucocorticoid-induced osteoporosis . Zhang et al. [[77]] demonstrated that RANKL was directly regulated by miR-338-3p and reintroduction
osteoporosis 23394 and osteoblast differentiation. Serum circulating miRNAs were detected and profiled in patients with osteoporosis and bone fracture. Furthermore, increasing evidences show that epigenetic modifications are not static,
osteoporosis 23602 static, and are dynamic and even reversible. Thus, a deeper understanding of the role of miRNAs in osteoporosis and bone fracture can inspire critical implications for the early diagnosis and prevention of osteoporosis.
osteoporosis 23709 osteoporosis and bone fracture can inspire critical implications for the early diagnosis and prevention of osteoporosis . It also can provide unique opportunities to develop novel therapeutic approaches of osteoporosis and
osteoporosis 23807 of osteoporosis. It also can provide unique opportunities to develop novel therapeutic approaches of osteoporosis and its related bone fracture

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