How non-functioning pituitary adenomas can affect health-related quality of life: a conceptual model and literature review.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
adrenal insufficiency 5 endocrinologydiseases
cortisol 7 endocrinologydiseasesdrugs
hypopituitarism 7 endocrinologydiseases
pituitary apoplexy 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
cortisol 8101 stimulating hormone, and prolactin, and dynamic stimulation tests for adrenocorticotrope hormone (ACTH), cortisol and growth hormone, and measurement of urine production for vasopressin deficiency [[17]]. Mild hypopituitarism
cortisol 8667 as possible. Replacement therapy for adrenal insufficiency is of particular relevance, since too low cortisol levels can lead to a potentially life threatening acute adrenal crisis (i.e. Addison’s crisis). Contrary
cortisol 8845 crisis (i.e. Addison’s crisis). Contrary to this, when replacement therapy exceeds supra-physiological cortisol levels, it can result in Cushing’s syndrome like symptoms. Therefore, adequate replacement therapy
cortisol 9459 available physiological measures do not always reliably represent the clinical situation. The assessment of cortisol levels in scalp hair is a relatively new method to assess cortisol exposure over longer time periods
cortisol 9526 clinical situation. The assessment of cortisol levels in scalp hair is a relatively new method to assess cortisol exposure over longer time periods and has been evaluated in patients with primary and secondary adrenal
cortisol 9703 with primary and secondary adrenal insufficiency [[19]]. Furthermore, it was examined whether hair cortisol levels correlated with patient reported HR-QoL, and it appeared that HR-QoL correlates slightly with
cortisol 9818 correlated with patient reported HR-QoL, and it appeared that HR-QoL correlates slightly with hair cortisol levels [[20]]. These results are not surprising, considering the Wilson–Cleary model with biological
Select Disease Character Offset Disease Term Instance
adrenal insufficiency 8603 therapy, aiming to mimic the physiology of end organ hormones as good as possible. Replacement therapy for adrenal insufficiency is of particular relevance, since too low cortisol levels can lead to a potentially life threatening
adrenal insufficiency 8958 levels, it can result in Cushing’s syndrome like symptoms. Therefore, adequate replacement therapy in adrenal insufficiency as well as, adaptation of the dose during stress, is crucial [[18]]. In clinical practice, endocrine
adrenal insufficiency 9631 cortisol exposure over longer time periods and has been evaluated in patients with primary and secondary adrenal insufficiency [[19]]. Furthermore, it was examined whether hair cortisol levels correlated with patient reported HR-QoL,
adrenal insufficiency 12858 Joustra et al. examined sleep characteristics in patients treated for a NFA and patients with primary adrenal insufficiency treated with hydrocortisone replacement therapy and demonstrated that patients with primary adrenal
adrenal insufficiency 12972 insufficiency treated with hydrocortisone replacement therapy and demonstrated that patients with primary adrenal insufficiency have normal sleep characteristics in contrast to patients with a NFA. These results provided evidence
hypopituitarism 3721 factors have been reported, including visual function, type of surgery (craniotomy vs. transsphenoidal), hypopituitarism , and the need for hormone replacement therapy [[4]].The aim of the present review was to provide an
hypopituitarism 7922 e.g. mass effect of the tumour, surgical treatment, or radiotherapy. Severe hormone deficits, (pan) hypopituitarism , is diagnosed by blood sampling for gonadotropin, thyroid stimulating hormone, and prolactin, and dynamic
hypopituitarism 8206 cortisol and growth hormone, and measurement of urine production for vasopressin deficiency [[17]]. Mild hypopituitarism can be difficult to diagnose, due to individual set-points, hormone sensitivity, and circadian variability.
hypopituitarism 8354 due to individual set-points, hormone sensitivity, and circadian variability. Nevertheless, also mild hypopituitarism may affect end organ function. Therefore, the majority of the patients with hypopituitarism need lifelong
hypopituitarism 8446 also mild hypopituitarism may affect end organ function. Therefore, the majority of the patients with hypopituitarism need lifelong hormone replacement therapy, aiming to mimic the physiology of end organ hormones as good
hypopituitarism 10660 diagnosis, giving either compression on the pituitary or the optic chiasm, resulting in headaches, hypopituitarism , visual loss, third nerve palsy, pituitary apoplexy, tiredness, decreased libido, and sometimes even
hypopituitarism 22276 [8], [46]]. Furthermore, some studies demonstrated the negative effect of tumour recurrence [[7]], hypopituitarism [[5], [47]] and radiotherapy [[48]] on HR-QoL, while other did not (pituitary deficiency [[46]], radiotherapy
pituitary apoplexy 10709 pituitary or the optic chiasm, resulting in headaches, hypopituitarism, visual loss, third nerve palsy, pituitary apoplexy , tiredness, decreased libido, and sometimes even galactorrhoea [[3]]. These symptoms tend to improve

You must be authorized to submit a review.