Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research.

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diabetic foot 9 endocrinologydiseases
diabetic neuropathy 1 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases

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diabetes mellitus 2036 and clinical studies may help design future randomized clinical trials.BackgroundThe prevalence of diabetes mellitus has increased precipitously due to worldwide changes in nutrition and lifestyle, and is currently estimated
diabetic foot 57 Title: Stem Cell Research & TherapyStem cell therapy for diabetic foot ulcers: a review of preclinical and clinical researchLara LopesOcean SetiaAfsha AurshinaShirley LiuHaidi
diabetic foot 1767 efficiency compared to either therapy alone.ConclusionsStem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options
diabetic foot 4781 Scholar databases were searched on November 1, 2017. The search was performed using MeSH terms for “ diabetic foot ” paired with MeSH terms for “stem cell(s)” or “progenitor cells”, which resulted in 256 articles
diabetic foot 5064 articles were screened, and review and experimental research articles describing stem cell therapy for diabetic foot ulcers were included. Articles were excluded if they were duplicated articles, nontherapeutic studies,
diabetic foot 7091 studies are summarized in Table 1.Table 1Randomized clinical trials reporting stem cell therapy for diabetic foot ulcersAuthorYearNStudy designType of cellAdministration routeResultsFollow-up (months)Debin et al. [[91]]200850Two
diabetic foot 9654 day, BM-MSC bone marrow-derived mesenchymal stem cells, BM-MNC bone-marrow mononuclear cells, DFU diabetic foot ulcer, EPC endothelial progenitor cells, G-CSF granulocyte-colony stimulating factor, hUC-MSC human
diabetic foot 18902 PB-MSC.Table 4Studies reporting use of Granulocyte-colony Stimulating Factor as part of stem cell therapy for diabetic foot ulcersAuthorYearNG-CSF doseDuration (days)Study designType of cellAdministration routeResultsFollow-up
diabetic foot 23081 patient• Donor baking creation• High immunoincompatibility• Need for disease screening0(0%)22(41%)DFU diabetic foot ulcerAdministration routeLocal administrationNonvascular injections into tissue are currently the most
diabetic foot 28775 PB-MSC.Table 7Studies reporting percutaneous transluminal angioplasty as part of stem cell therapy for diabetic foot ulcersAuthorYearNStudy designType of cellAdministration routeResultsFollow-up (months)Huang et al. [[90]]201011Prospective,
diabetic neuropathy 2478 Foot as a full-thickness wound located below the ankle in a diabetic patient, and is associated with diabetic neuropathy and peripheral arterial disease [[2]]. More than 2% of the diabetic population develops a new foot ulcer

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