Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification

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Term Occurence Count Dictionary
hyperinsulinemia 1 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
obesity 1 endocrinologydiseases
vascular calcification 2 endocrinologydiseases
diabetes mellitus 10 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 5385 common biological effect in different CVDs generated by some causes such as aging, hyperlipidaemia, diabetes mellitus , hypertension (HT), smoking and uremic toxins, among others. Another common biological effect observed
diabetes mellitus 9995 disease [[51]], myocardial infarction [[51],[52]], atherosclerosis [[53]], ethnic-specific [[54]] and diabetes mellitus [[55]], indicating shared pathological components.3. SenescenceSenescence is defined as process that
diabetes mellitus 20804 associated with a premature aging process and considered as SIPS. Some of them are hyperlipidaemia, diabetes mellitus , HT, smoking and uremic toxins. It is interesting to remember that almost thirty years ago, Dzau [[101]]
diabetes mellitus 21917 atherosclerosis and cellular senescence in the absence of pathological conditions, such as hyperlipidaemia or diabetes mellitus [[102]].OxLDL is produced when nLDL is scarce and irreversibly oxidized due to active circulating oxidants
diabetes mellitus 23179 number and phenotype of MVs have been associated with major cardiovascular risk factors such as smoking, diabetes mellitus , obesity, HT, dyslipidaemia and metabolic syndrome [[19]].3.2.2. Diabetes MellitusDiabetes mellitus
diabetes mellitus 23491 arterial occlusion), CKDs, neuropathy and retinopathy (microvascular disease) [[113]]. Concretely, diabetes mellitus is associated with high rates vascular diseases (coronary artery disease, cerebral vascular disease
diabetes mellitus 23976 impaired response to injury also contribute to this process [[41],[42],[43]]. The cells affected by diabetes mellitus on the vasculature are extensive but the principal cells are endothelium and smooth muscle cells [[41]].Plenty
diabetes mellitus 24133 the principal cells are endothelium and smooth muscle cells [[41]].Plenty of data exists showing that diabetes mellitus patients have accelerated atherosclerotic vascular disease [[114]]. Moreover, evidence indicates that
diabetes mellitus 24988 novel effector that implied the interrelation risk factors in a cluster of cardiovascular disease and diabetes mellitus (metabolic syndrome) [[117]]. To conclude, EVs in diabetes mellitus, together with pathological processes
diabetes mellitus 25056 cluster of cardiovascular disease and diabetes mellitus (metabolic syndrome) [[117]]. To conclude, EVs in diabetes mellitus , together with pathological processes including aging and inflammation, both are implied in oxidative
glucose intolerance 20996 thirty years ago, Dzau [[101]] described how some associated-pathologies like HT, dyslipidaemia and glucose intolerance , cluster in the population and act synergistically in increasing and interacting with atherosclerosis.3.2.1.
hyperinsulinemia 26517 contribute to the atherosclerosis progression and acceleration of this process. Additionally, diabetes and hyperinsulinemia also generate some effects in the vasculature, increasing vascular tone and vascular smooth muscle cell
metabolic syndrome 23229 major cardiovascular risk factors such as smoking, diabetes mellitus, obesity, HT, dyslipidaemia and metabolic syndrome [[19]].3.2.2. Diabetes MellitusDiabetes mellitus is a risk factor for several pathologies highlighted
metabolic syndrome 25007 implied the interrelation risk factors in a cluster of cardiovascular disease and diabetes mellitus ( metabolic syndrome ) [[117]]. To conclude, EVs in diabetes mellitus, together with pathological processes including aging
obesity 23198 MVs have been associated with major cardiovascular risk factors such as smoking, diabetes mellitus, obesity , HT, dyslipidaemia and metabolic syndrome [[19]].3.2.2. Diabetes MellitusDiabetes mellitus is a risk
vascular calcification 2621 diseases (CVDs). Its main features are endothelial dysfunction, intimal thickening, inflammation and vascular calcification (VC) [[1],[2],[3]]. To date, oxidative stress, endothelial dysfunction and inflammation play a critical
vascular calcification 3160 deposits in the vascular area of advanced (also named complicated) plaques [[6],[7]]. Moreover, cardio vascular calcification is a growing burden in aging societies of occidental descent and contributes to cardiovascular disease.Extracellular

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