Dysfunction of Mesenchymal Stem Cells Isolated from Metabolic Syndrome and Type 2 Diabetic Patients as Result of Oxidative Stress and Autophagy may Limit Their Potential Therapeutic Use.

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hyperglycemia 1 endocrinologydiseases
metabolic syndrome 12 endocrinologydiseases
obesity 2 endocrinologydiseases

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hyperglycemia 19434 shown that ROS are produced in various tissues under diabetic conditions [[69]]. In the diabetic state, hyperglycemia and subsequent ROS production decrease insulin expression and secretion and cause apoptosis [[70]–[72]].
metabolic syndrome 897 involvement of MSCs in ageing and disease. In this review, we have focused on how type 2 diabetes (T2D) and metabolic syndrome (MS) affect MSC properties, and thus limit their therapeutic potential. Herein, we mainly focus on apoptosis,
metabolic syndrome 1412 (MSC)Progressive obesity, insulin resistance, abnormal cholesterol or triglyceride levels that lead to metabolic syndrome (MS) and finally type 2 diabetes (T2D) are emerging problems in the current endocrinology. As reported
metabolic syndrome 2060 care system. Many strategies have been recently proposed to minimize health-related consequences of metabolic syndrome and diabetes. They involve new drug development, including, e.g., glucagon-like peptide (GLP-1) mimetic,
metabolic syndrome 4282 cells, is a promising candidate in the field of endocrine disorders, including type 2 diabetes and metabolic syndrome [[15]–[17]]. Here, we analyze physiological characteristics and deterioration of MSCs in metabolic
metabolic syndrome 4392 syndrome [[15]–[17]]. Here, we analyze physiological characteristics and deterioration of MSCs in metabolic syndrome and diabetes in the context of their potential clinical application.MSC and Membrane-Derived Vesicles
metabolic syndrome 5395 have been detected in the circulation and in organs during various diseases, including diabetes and metabolic syndrome [[23]]. Patients suffering from those disorders, have different cellular MV patterns and those MVs contribute
metabolic syndrome 9401 of adipose tissue negatively affects MSC stemness. It was found that MSCs isolated from EMS (equine metabolic syndrome ) individuals suffered from many deteriorations, including decreased proliferation rate, clonogenic potential
metabolic syndrome 22446 autophagic turnover to generate ATP necessary for effective differentiation [[50]]. MSC deterioration in metabolic syndrome , including ROS, mitochondria damage and epigenetic alternations is visualized in Fig. 1.Fig. 1Mesenchymal
metabolic syndrome 22597 damage and epigenetic alternations is visualized in Fig. 1.Fig. 1Mesenchymal stem cell dysfunction in metabolic syndrome Similar results were obtained during chondrogenic differentiation of MSMSC, as reduced number of mitochondria
metabolic syndrome 23473 [[79], [80]]. However, research in these areas is in its infancy. Only few studies have investigated how metabolic syndrome or diabetes affect cytophysiological characteristics of mesenchymal stem cells, such as mitochondria
metabolic syndrome 24862 may be beneficial in reversing ROS induced damage and mitochondrial impairment of MSC derived from metabolic syndrome individuals [[75]]. Authors, have demonstrated that Spirulina platensis extract enhanced viability,
metabolic syndrome 25235 platensis was confirmed in vivo. Algae supplementation decreased weight and improved insulin sensitivity in metabolic syndrome animals. To summarize, application of substances able to reduce oxidative stress in MSCs may in consequence
obesity 1326 treatments, as their therapeutic potential may be restricted.Mesenchymal Stem Cells (MSC)Progressive obesity , insulin resistance, abnormal cholesterol or triglyceride levels that lead to metabolic syndrome (MS)
obesity 10365 obese, diabetic mice and humans. Interestingly, CD44 knockout mice fed a high fat diet, did not develop obesity or T2D. The upregulation of CD44 led to migration and infiltration of activated immune cells, increasing

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