Potential Interplay between Hyperosmolarity and Inflammation on Retinal Pigmented Epithelium in Pathogenesis of Diabetic Retinopathy.

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diabetic retinopathy 6 endocrinologydiseases
hyperglycemia 1 endocrinologydiseases

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diabetic retinopathy 1099 barriers protect the retina by regulating ion, protein, and water flux into and out of the retina. During diabetic retinopathy , many factors, including inflammation, contribute to the rupture of the inner and/or the outer blood-retinal
diabetic retinopathy 1685 possible origins and consequences of hyperosmolar stress on retinal pigmented epithelial cells during diabetic retinopathy , with a special focus on the intimate interplay between inflammation and hyperosmolar stress, as well
diabetic retinopathy 3260 [[2]]. Either iBRB or oBRB rupture can occur during the course of several ocular pathologies, including diabetic retinopathy (DR). BRB rupture results in increased osmotic pressure in the retina, leading to important water accumulation
diabetic retinopathy 5671 [[13],[14],[15],[16],[17]]. Indeed, Th17-IL-17 axis has been shown to play a role in the pathogenesis of diabetes and diabetic retinopathy (DR), as well as in autoimmune uveitis [[18],[19],[20],[21]]. Therefore, it is likely that HSD and HOS
diabetic retinopathy 18705 suggested to participate to the pathogenesis of DR due to its high levels in patients with proliferative diabetic retinopathy [[87]]. Furthermore, HMGB1 induced in vitro cytotoxic effects on glial cells, which contributed to pericytes
diabetic retinopathy 31222 secretion (green arrow).Figure 2Intact and all theoretical blood retinal barrier BRB ruptures during diabetic retinopathy (DR). Schematic representation of: (A) intact iBRB and oBRB; (B) iBRB rupture without concomitant OLM
hyperglycemia 14992 they block the increase in retinal VEGF levels found in diabetic rats.In this context of inflammation, hyperglycemia affects Tumor necrosis alpha (TNF╬▒) and interleukin 6 (IL6) plasma levels [[68]], as well as local

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