Resveratrol Counteracts Insulin Resistance-Potential Role of the Circulation

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Term Occurence Count Dictionary
Insulin 6 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
diabetic retinopathy 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs
osteoporosis 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases

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Insulin 40 Title: NutrientsResveratrol Counteracts Insulin Resistance—Potential Role of the CirculationRachel H. X. WongPeter R. C. Howe1School of Biomedical
Insulin 1472 resveratrol may play a role in preventing or alleviating insulin resistance. 1. Does Resveratrol Improve Insulin Sensitivity? Evidence from Clinical TrialsThe search for naturally occurring compounds that may help
Insulin 2880 a result, potential cardiovascular benefits of resveratrol have been extensively studied [[3],[4]]. Insulin resistance, the primary abnormality of and risk factor for T2DM, is characterized by reduced insulin-mediated
Insulin 3918 storage, the vasodilator effects of insulin in skeletal muscle is of primary importance in this review. Insulin resistance, initiated by ageing, excessive dietary fat or glucose intake, or adiposity, can concertedly
Insulin 4322 self-perpetuating cycle of hyperinsulinaemia and hyperglycaemia [[8],[9]]. The Homeostatic Model for Assessment of Insulin Resistance (HOMA-IR) is a validated algorithm that uses the product of fasting blood glucose and insulin
Insulin 9078 muscle to facilitate glucose uptake and utilization. 2. Mechanisms by Which Resveratrol May Improve Insulin Sensitivity in Skeletal Muscle2.1. Human Sirtuin 1 (SIRT1) and AMP-Activated Protein Kinase (AMPK) ActivationSince
metformin 6473 [[3]]. Nonetheless, it was argued that the trial participants were using a relatively high dose of metformin , which resulted in higher plasma levels of dihydro-resveratrol, a metabolite of resveratrol, suggesting
Select Disease Character Offset Disease Term Instance
diabetes mellitus 962 function, yet the possibility that this action might help to alleviate insulin resistance in type-2 diabetes mellitus has received little attention. In this brief review we propose that, by restoring impaired endothelium-dependent
diabetes mellitus 1599 Evidence from Clinical TrialsThe search for naturally occurring compounds that may help to prevent type 2 diabetes mellitus (T2DM) is gaining increasing attention. Whilst insulin resistance is a risk factor for developing T2DM,
diabetic retinopathy 15346 (reduction in the density of capillaries) and tissue ischaemia, resulting in end-organ damage as in diabetic retinopathy . The mechanisms through which resveratrol may improve insulin sensitivity in T2DM are complex, encompassing
glucose intolerance 15095 leading to a self-perpetuating cycle of hyperinsulinaemia and hyperglycaemia that ultimately results in glucose intolerance and exacerbates the endothelial dysfunction [[9],[48],[49]]. This impairment leads to arterial hypertension,
metabolic syndrome 8279 regulator of mitochondrial biogenesis and metabolism [[25]]. However, this finding contradicts a study in metabolic syndrome patients that found significant reductions in the area-under-the-curve of the postprandial rise in insulin
osteoporosis 19458 menopause are equally, if not more, vulnerable to chronic diseases such as cognitive impairment, T2DM and osteoporosis [[62],[63],[64]]; these conditions are partially attributable to poor circulatory function. Hence, the
type 2 diabetes mellitus 1592 Evidence from Clinical TrialsThe search for naturally occurring compounds that may help to prevent type 2 diabetes mellitus (T2DM) is gaining increasing attention. Whilst insulin resistance is a risk factor for developing T2DM,

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