Mesenchymal Stem Cells as New Therapeutic Approach for Diabetes and Pancreatic Disorders

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Term Occurence Count Dictionary
Insulin 1 endocrinologydiseasesdrugs
cholic acid 1 endocrinologydiseasesdrugs
hyperglycemia 7 endocrinologydiseases
hypertriglyceridemia 3 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 31876 disorders.DisorderUnderlying mechanismsType I DiabetesImmune-mediated β-cell destructionType II Diabetes Insulin resistance and insulin deficiencyType III Diabetesa. Genetic defects β-cell functionb. Genetic defects
cholic acid 21620 the use of the most common experimental induction model, that is, the intraductal injection of tauro cholic acid (TCA) into rats [[49]]. In other experimental models, acute pancreatitis has been induced by the injection
Select Disease Character Offset Disease Term Instance
hyperglycemia 4333 these different diabetes forms have very different etiology; nevertheless, they share a common symptom: hyperglycemia .Hyperglycemia is the trigger factor that leads to organ dysfunction and long-term complications, such
hyperglycemia 5335 with ROS generation leading to general cellular dysfunction [[4]]. It has been also suggested that hyperglycemia leads to diacylglycerol increase, which actives protein kinase C (PKC) that, in turn, alters collagen
hyperglycemia 8195 fluid resuscitation, analgesia and nutritional support, however, more than 50% of patients develop hyperglycemia and 5% develop diabetes. On the other hand, acute pancreatitis represents a clinical complication for
hyperglycemia 9661 forms, which is mandatory for the right management and treatment of patients [[12]]. As reported above, hyperglycemia is a common aspect of all diabetes form, but it is also present in other pancreatic diseases, thus,
hyperglycemia 10265 elements in terms of metabolic signs. Certainly the common denominator of all pancreatic disorders is hyperglycemia , which is the consequence of: β-cell loss in type-I diabetes, insulin-resistance for type-II diabetes,
hyperglycemia 12783 In the same way, insulin resistance and hyperinsulinaemia, occurring in Type II diabetes, as well as hyperglycemia , can promote the proliferation of pancreatic cancer [[18]], thus meaning that diabetes may represent
hyperglycemia 16834 described, diabetes is a serious metabolic worldwide-spread disease characterized by the presence of hyperglycemia , which may be caused by an alteration of insulin production dependent on the autoimmune destruction
hypertriglyceridemia 7506 transport. Generally, the first cause of pancreatic inflammation is the presence of gallstones, followed by hypertriglyceridemia , alcohol abuse and, in a low percentage, acute pancreatitis could occur after endoscopic retrograde
hypertriglyceridemia 8388 clinical complication for type-II diabetic patients, in which the trigger factor is supposed to be the hypertriglyceridemia [[7]].2.2.2. Chronic PancreatitisWhen pancreatic tissue inflammation persists, acute pancreatitis progresses
hypertriglyceridemia 11439 [[15]]. Dyslipidemia is also observed during the course of acute and chronic pancreatitis. In particular hypertriglyceridemia is itself one of the principal cause of acute pancreatitis, while, in patients affected by chronic pancreatitis,
metabolic syndrome 30181 therefore, their amount available for transplantation [[62]], it is noteworthy that MSCs derived from metabolic syndrome and diabetes patients can present several problems. In fact, in such cells an increase of detrimental

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