Modeling Endometrial Cancer: Past, Present, and Future

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Annotation Summary

Term Occurence Count Dictionary
bromocriptine 1 endocrinologydiseasesdrugs
cyclophosphamide 1 endocrinologydiseasesdrugs
endometrial carcinoma 5 endocrinologydiseases
estrone 3 endocrinologydiseasesdrugs
obesity 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
bromocriptine 20206 [[76],[77]]. Yoshida et al. and Kojima et al. showed that compounds decreasing the E:P ratio, such as bromocriptine and indole-3-carbinole, have a protective effect against EC [[77],[78]], while compounds increasing
cyclophosphamide 3913 combined with adjuvant radiotherapy and/or chemotherapy such as cisplatin, carboplatin, doxorubicin, and cyclophosphamide [[6],[8],[9]]. Since for recurrent and metastatic disease only limited treatment options are available
estrone 24349 combination with estrogens [[99],[101],[102]]. Takahashi et al. showed that ENNG combined with estradiol, estrone , estriol, 16β-hydroxyestrone, 16α-hydroxyestrone, and 17-epiestriol significantly induces endometrial
estrone 24379 [[99],[101],[102]]. Takahashi et al. showed that ENNG combined with estradiol, estrone, estriol, 16β-hydroxy estrone , 16α-hydroxyestrone, and 17-epiestriol significantly induces endometrial adenocarcinoma tumor formation
estrone 24400 et al. showed that ENNG combined with estradiol, estrone, estriol, 16β-hydroxyestrone, 16α-hydroxy estrone , and 17-epiestriol significantly induces endometrial adenocarcinoma tumor formation and progression
Select Disease Character Offset Disease Term Instance
endometrial carcinoma 21731 levels. If kept to their natural life end (around 26–27 months), over 90% of the female rats die due to endometrial carcinoma [[73],[83]]. Using gene sequencing and real-time PCR, Samuelson et al. showed that tumors in BDII/Han
endometrial carcinoma 24941 2-methoxyestradiol, 2-methoxyestriol, and 16-epiestriol, have only limited to no effect on the growth of endometrial carcinoma s [[99]].Chemically induced EC animal models have been used as translational models to investigate the
endometrial carcinoma 26702 re-implantation [[107]]. It has been shown that PTEN inactivation per se is sufficient to rapidly induce endometrial carcinoma [[105]]. Since microsatellite instability is a highly frequent event in endometrioid EC, Wang et al.
endometrial carcinoma 26991 MLH−/− deletion next to the heterozygous PTEN loss (PTEN+/−) and showed an accelerated onset of endometrial carcinoma [[18],[108]], confirming the role of microsatellite instability in EC. The importance of alterations
endometrial carcinoma 30104 [[115]] and the depletion of estrogen predominantly leads to neoplastic lesions, possibly explaining why endometrial carcinoma incidence is higher in peri- and postmenopausal women [[116]].4.3.4. Transgenic Models: RemarksIn many
obesity 2721 the development of EC are (i) exposure to unopposed estrogens or to tamoxifen, (ii) diabetes, (iii) obesity , (iv) nulliparity, (v) early-onset menarche, and (vi) late-onset menopause, amongst others [[6]]. The

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