Successful management of multiple-systemic Langerhans cell histiocytosis involving endocrine organs in an adult: A case report and review of literature.

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Term Occurence Count Dictionary
panhypopituitarism 1 endocrinologydiseases
thalidomide 1 endocrinologydiseasesdrugs
thyroglobulin 1 endocrinologydiseasesdrugs
desmopressin 1 endocrinologydiseasesdrugs
hyperparathyroidism 1 endocrinologydiseases
obesity 1 endocrinologydiseases
hypopituitarism 1 endocrinologydiseases
hypothyroidism 2 endocrinologydiseases
prednisone 2 endocrinologydiseasesdrugs
thyroiditis 2 endocrinologydiseases
diabetes insipidus 1 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases
goiter 2 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
desmopressin 4547 We considered the diagnosis of central diabetes insipidus (DI) and the patient received 3 tablets of desmopressin acetate (0.3 mg/day) with improvement of the symptoms. However, the thyroid and total bone ECT scan
prednisone 5892 the normal range. Further, the patient received chemotherapy of CHOP regime (CTX1350 mg, VCR2 mg, prednisone 100 mg for 5 days,) and radiation therapy of 11 regimens including 16.5 Gy dose. Surprisingly, we
prednisone 16723 contrary, higher risk LCH should adopt more prolonged and intensive combination chemotherapy such as prednisone , etoposide, vinblastine, 6-mercaptopurine and methotrexate for 12 months in order to improve the long-term
thalidomide 18213 clofarabine, a new generation of deoxyadenosine analog, intermediate-dose methotrexate (100–175 mg/m2), thalidomide , tumor necrosis factor and its inhibitor, cyclosporine-A and stem cell transplantation all have been
thyroglobulin 3690 LCH because immunohistochemistry staining confirmed CD1a (+), S100 (+), CD68 (+), Valentine (+), and thyroglobulin (+). The thyroid lesion gradually improved after the patient further received radiotherapy of 16 regimens
Select Disease Character Offset Disease Term Instance
diabetes insipidus 4485 signal and the pituitary stalk was slightly thicker (Fig. 2). We considered the diagnosis of central diabetes insipidus (DI) and the patient received 3 tablets of desmopressin acetate (0.3 mg/day) with improvement of the
diabetes mellitus 14117 worth noting that endocrine dysfunctions such as primary hypothyroidism, hyperparathyroidism and even diabetes mellitus are easily ignored in the patients with LCH by physicians.Involvement of liver3.4LCH involving the liver
goiter 765 a case of multiple-systemic Langerhans cell histiocytosis (LCH) that first manifested with thyroid goiter , followed by pituitary and liver involvement.Diagnoses:The diagnosis was confirmed based on immunohistochemistry
goiter 10129 during the recent 50 years (75% were adults and others were children), 59% of which presented with goiter , 25.8% of which presented with thyroid nodules and 40.9% of which presented with euthyroid, followed
hyperparathyroidism 14088 autopsy findings.[[11]] It is worth noting that endocrine dysfunctions such as primary hypothyroidism, hyperparathyroidism and even diabetes mellitus are easily ignored in the patients with LCH by physicians.Involvement of
hypopituitarism 12499 (7/12), thyroid-stimulating hormone-adrenocorticotrophic hormone (TSH-ACTH) deficiency (5/12) and pan hypopituitarism (5/12). Another study also draw similar conclusions: the incidence of GH deficiency (54% at 10 years)
hypothyroidism 3990 function of thyroid and began to take 50 μg Euthyrox (levothyroxine) per day since being diagnosed with hypothyroidism 3 years after subtotal thyroidectomy. In 2007, the patient was again admitted to our hospital with the
hypothyroidism 14072 radiological or autopsy findings.[[11]] It is worth noting that endocrine dysfunctions such as primary hypothyroidism , hyperparathyroidism and even diabetes mellitus are easily ignored in the patients with LCH by physicians.Involvement
obesity 11775 clinic manifestations usually were nonspecific, presented with common complaints: appetite (morbid obesity ), thermoregulation (hypothermia), adipsia, sleep, and short-term memory.[[8]] The retrospective research
panhypopituitarism 12496 deficiency (7/12), thyroid-stimulating hormone-adrenocorticotrophic hormone (TSH-ACTH) deficiency (5/12) and panhypopituitarism (5/12). Another study also draw similar conclusions: the incidence of GH deficiency (54% at 10 years)
thyroiditis 10579 misdiagnosed as the following diseases: benign tumors, undifferentiated carcinoma, lymphoma, lymphoid thyroiditis , chronic granulomatous thyroiditis although fine- needle aspiration is essential for LCH.[[7]] The experts
thyroiditis 10614 diseases: benign tumors, undifferentiated carcinoma, lymphoma, lymphoid thyroiditis, chronic granulomatous thyroiditis although fine- needle aspiration is essential for LCH.[[7]] The experts suggested that physicians should

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