iPSC technology-based regenerative therapy for diabetes.

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Annotation Summary

Term Occurence Count Dictionary
hyperglycemia 1 endocrinologydiseases
lipodystrophy 1 endocrinologydiseases
potassium chloride 1 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
potassium chloride 7799 generated pancreatic β‐like cells that produce and secrete insulin in response to stimuli, such as potassium chloride 7, 17. However, these cells do not secrete suitable amounts of insulin in response to changes in blood
Select Disease Character Offset Disease Term Instance
diabetes mellitus 21708 describe the generation of iPSCs from patients with diabetes‐related disorders, including types 1 and 2 diabetes mellitus ; maturity‐onset diabetes of the young types 1, 2, 3, 5 and 8, in which a single gene mutation causes
hyperglycemia 25932 showed intrapatient variations in differentiation propensity to insulin‐producing cells49T2DNAMarked hyperglycemia disrupted anesthetic preconditioning‐mediated protection in cadiomyocytes from patient‐derived iPSCs48T1D
lipodystrophy 24184 show compensatory mechanisms in the pancreatic transcription factor network62Congenital generalized lipodystrophy BSCL2/SEIPIN (E189X and R275X)Adipogenic differentiation of patient‐derived iPSCs exhibited reduction

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