Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis.

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Term Occurence Count Dictionary
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 11 endocrinologydiseases
diabetic retinopathy 17 endocrinologydiseases
obesity 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 33826 (0.88-2.27)1.420.156Risk factor 3-DM duration (per year increase)121.09 (1.06-1.12)5.93<0.001Risk factor 4- Insulin treatment51.99 (1.34-2.95)3.40.001Risk factor 5-FBG (per mmol/L increase)91.33 (1.12-1.59)3.230.001Risk
Select Disease Character Offset Disease Term Instance
diabetes mellitus 434 date: 6/2018AbstractBackgroundDiabetic retinopathy (DR), the primary retinal vascular complication of diabetes mellitus (DM), is a leading cause of vision impairment and blindness in working-age population globally. Despite
diabetes mellitus 3254 studies on DR are still required.Diabetic retinopathy (DR), the primary retinal vascular complication of diabetes mellitus (DM), is a leading cause of vision impairment and blindness in the working-age population [[1]-[4]].
diabetes mellitus 21841 Articles with no numerical prevalence measure of DR or didn’t report risk factor for DR in people with diabetes mellitus (DM); *Reason 4 – Studies with no clear assessment methods or grading systems of DR; *Reason 5 –
diabetes mellitus 24191 (9.5)Southwest China1 (3.2)1 (4.8)Northwest China5 (16.1)0 (0.0)DR – diabetic retinopathy, DM – diabetes mellitus , PHCM – Primary Health Care Management, ICDRDSS – International Clinical Diabetic Retinopathy Disease
diabetes mellitus 27104 prevalence of nonproliferative diabetic retinopathy (NPDR) in general population and in people with diabetes mellitus (DM) by random-effects meta-analysis. There were 14 studies for synthesizing the prevalence of NPDR
diabetes mellitus 28398 5Pooled prevalence of proliferative diabetic retinopathy (PDR) in general population and in people with diabetes mellitus (DM) by random-effects meta-analysis. There were 14 studies for synthesizing the prevalence of PDR in
diabetes mellitus 29507 Supplementary Document).Figure 6Age-specific prevalence of any diabetic retinopathy (DR) in people with diabetes mellitus (DM) by random-effects meta-analysis. The numbers of individual studies contributing to the synthesis
diabetes mellitus 30610 Document(Online Supplementary Document).Figure 7The prevalence of any diabetic retinopathy (DR) by diabetes mellitus (DM) duration group, using random-effects meta-analysis. The numbers of individual studies contributing
diabetes mellitus 33553 Document).Table 4Synthesized effect size of 11 risk factors for any diabetic retinopathy in people with diabetes mellitus Risk factorNumber of studiesOR (95% CI)z valueP-valueRisk factor 1-Advanced age (per year increase)40.96
diabetes mellitus 34374 11-SBP (per mmHg increase)51.03 (1.00-1.07)1.960.05OR – odds ratio, CI – confidence interval, DM – diabetes mellitus , FBG – fasting blood glucose, PBG – postprandial blood glucose, HbA1c – glycated haemoglobin A1c,TC
diabetes mellitus 36926 (0.60-1.18)China3.06 (2.08-4.19)18.24 (12.41-24.95)13.16 (8.95-18.00)DR – diabetic retinopathy, DM – diabetes mellitus , CI – confidence intervalFigure 8Estimated regional number of middle-aged and older Chinese with any
diabetic retinopathy 70 Title: Journal of Global HealthPrevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysisAlternative Title: Song et al. Prevalence, risk factors
diabetic retinopathy 208 systematic review and meta-analysisAlternative Title: Song et al. Prevalence, risk factors and burden of diabetic retinopathy in ChinaPeige SongJinyue YuKit Yee ChanEvropi TheodoratouIgor RudanPublication date: 6/2018Publication
diabetic retinopathy 8831 that reported the epidemiology of DR in China. Our comprehensive search strategies combined terms of diabetic retinopathy , epidemiology (incidence, prevalence, morbidity, mortality, epidemiology) and China (China, Chinese,
diabetic retinopathy 21512 Document).Figure 1Systematic review flow diagram of studies on the prevalence of and risk factors for diabetic retinopathy (DR) in China. PHCM - Primary Health Care Management; *Reason 1 – Studies that were not community-based,
diabetic retinopathy 23260 Figure 2).Table 2Main characteristics of the included studies on the prevalence of and risk factors for diabetic retinopathy in China*Characteristics of studyNumber of studies (%)Studies on DR prevalence (n = 31)Studies on
diabetic retinopathy 24162 (38.1)South Central China4 (12.9)2 (9.5)Southwest China1 (3.2)1 (4.8)Northwest China5 (16.1)0 (0.0)DR – diabetic retinopathy , DM – diabetes mellitus, PHCM – Primary Health Care Management, ICDRDSS – International Clinical
diabetic retinopathy 24736 exceeded 41.Figure 2Geographical distribution of included studies on prevalence of and risk factors for diabetic retinopathy (DR) in China.Pooled prevalence of DR in China during 1990 and 2017By using random-effects meta-analysis,
diabetic retinopathy 25728 S4 in Online Supplementary Document(Online Supplementary Document)).Figure 3Pooled prevalence of any diabetic retinopathy (DR) in general population and in people with DM by random-effects meta-analysis. There were 28 studies
diabetic retinopathy 27035 Supplementary Document(Online Supplementary Document)).Figure 4Pooled prevalence of nonproliferative diabetic retinopathy (NPDR) in general population and in people with diabetes mellitus (DM) by random-effects meta-analysis.
diabetic retinopathy 28330 Online Supplementary Document(Online Supplementary Document)).Figure 5Pooled prevalence of proliferative diabetic retinopathy (PDR) in general population and in people with diabetes mellitus (DM) by random-effects meta-analysis.
diabetic retinopathy 29466 Online Supplementary Document(Online Supplementary Document).Figure 6Age-specific prevalence of any diabetic retinopathy (DR) in people with diabetes mellitus (DM) by random-effects meta-analysis. The numbers of individual
diabetic retinopathy 30581 Figure S10 in Online Supplementary Document(Online Supplementary Document).Figure 7The prevalence of any diabetic retinopathy (DR) by diabetes mellitus (DM) duration group, using random-effects meta-analysis. The numbers of individual
diabetic retinopathy 31263 secular trend in the prevalence of any DR in individuals with DM was observed.Table 3Odds ratios for any diabetic retinopathy in terms of setting, geographic region and study year from univariable meta-regression models, with
diabetic retinopathy 33517 Supplementary Document(Online Supplementary Document).Table 4Synthesized effect size of 11 risk factors for any diabetic retinopathy in people with diabetes mellitusRisk factorNumber of studiesOR (95% CI)z valueP-valueRisk factor 1-Advanced
diabetic retinopathy 36234 CI = 11.97-24.24]).Table 5Estimated prevalence and number of middle-aged and older Chinese with any diabetic retinopathy in China in 2010, by geographic regionRegionPrevalence of any DR in general people (%, 95% CI)Prevalence
diabetic retinopathy 36897 (2.12-4.20)19.39 (13.30-26.35)0.87 (0.60-1.18)China3.06 (2.08-4.19)18.24 (12.41-24.95)13.16 (8.95-18.00)DR – diabetic retinopathy , DM – diabetes mellitus, CI – confidence intervalFigure 8Estimated regional number of middle-aged
diabetic retinopathy 37047 – confidence intervalFigure 8Estimated regional number of middle-aged and older Chinese with any diabetic retinopathy (DR) and contributing age groups in 2010.DISCUSSIONBy combining all available epidemiological data on
obesity 45368 people with higher risk for pre-diabetes (eg, people with familial DM history, hypertension, overweight/ obesity , dyslipidemia, cardiovascular disease /stroke or a gestational history of large babies [for women])

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