Rebelling against the (Insulin) Resistance: A Review of the Proposed Insulin-Sensitizing Actions of Soybeans, Chickpeas, and Their Bioactive Compounds.

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Term Occurence Count Dictionary
hyperglycemia 1 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
obesity 2 endocrinologydiseases
Insulin 18 endocrinologydiseasesdrugs
dexamethasone 2 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
Insulin 39 Title: NutrientsRebelling against the ( Insulin ) Resistance: A Review of the Proposed Insulin-Sensitizing Actions of Soybeans, Chickpeas, and Their
Insulin 85 Title: NutrientsRebelling against the (Insulin) Resistance: A Review of the Proposed Insulin -Sensitizing Actions of Soybeans, Chickpeas, and Their Bioactive CompoundsJaime L. ClarkCarla G. TaylorPeter
Insulin 682 Winnipeg, MB R3E 0T5, CanadaPublication date (epub): 3/2018Publication date (collection): 4/2018Abstract Insulin resistance is a major risk factor for diseases such as type 2 diabetes and metabolic syndrome. Current
Insulin 11449 be discussed within the scope of this review.4. The Proposed Mechanisms of Action for Reduction of Insulin Resistance by Soybeans and Pulses4.1. Glucose Transporter-4 and Glucose UtilizationUnder normal conditions,
Insulin 12940 studies to determine effects on adipogenesis and related processes, such as glucose uptake [[50],[51]]. Insulin resistance was induced in the preadipocytes by treating with dexamethasone and insulin for 60 h (eight
Insulin 57810 medium-dose ISO (150 mg/kg/day i.g.); (5) HFD + high-dose ISO (450 mg/kg/day i.g.)⋅30-day study⋅ Insulin resistance index (HOMA-IR)⋅Fasting insulin (RIA kit)⋅Fasting plasma glucose (commercial reagent
Insulin 60127 mg/kg/day by oral gavage)⋅Study 1: 147 days; Study 2: 15 days⋅Glucose tolerance test (glucometer)⋅ Insulin resistance test (0.75 Units insulin injected intraperitoneally; tail vein blood samples)⋅Body composition
Insulin 60919 mg/day)⋅4-month study⋅Glucose tolerance test (femoral intravenous collection: 5, 10, 20, 30, 60 min) ⋅ Insulin resistance test (hyperinsulinemic-euglycemic clamp)⋅Fasting plasma glucose (colorimetric assay)⋅Fasting
Insulin 62222 glucose (glucometer)⋅Serum insulin (rat/mouse insulin enzyme-linked immunosorbent assay (ELISA) kit)⋅ Insulin resistance index (HOMA-IR)⋅Short-chain fatty acid analysis (luminal samples by high-performance liquid
Insulin 62835 chow; (2) high-fat diet (HFD); (3) HFD + chickpeas (10% raw, crushed chickpea seeds)⋅8-month study⋅ Insulin tolerance test (insulin at 2 Units/kg, intraperitoneal) ⋅Oral glucose tolerance test (fasting glucometer
Insulin 63810 study⋅Fasting serum glucose (enzyme assay kit)⋅Fasting serum insulin, adiponectin, leptin (ELISA kits)⋅ Insulin sensitivity (HOMA-IR)⋅Tissue weights (liver and adipose)⋅Adipocyte histology (hematoxylin & eosin
Insulin 64532 fibre⋅30-week study⋅Oral glucose tolerance test (fasting glucometer readings from tail vein)⋅ Insulin sensitivity (HOMA-IR)⋅Adipocyte histology (hematoxylin & eosin stain)⋅mRNA levels (RT-PCR)⋅Enzyme
Insulin 65138 g)⋅Groups: (1) Basal diet + 15% methylcellulose (Control); (2) Basal diet + 15% w/w GOS⋅9-week study⋅ Insulin sensitivity (hyperinsulinemic-euglycemic clamp)⋅Gut microbial populations (DNA isolated from fecal
Insulin 66841 adipocytesSoybean (Glycine max. L.)Huang et al. [[49]]⋅3T3-L1 preadipocytes⋅Differentiated post-confluence⋅ Insulin resistance induced (1 mM dexamethasone, 10% fetal bovine serum, 10 mg/L insulin for 2 days)⋅Vehicle
Insulin 68230 protein levels vs. vehicleN/ALuna-Vital et al. [[54]]⋅3T3-L1 adipocytes⋅Differentiated after 48 h⋅ Insulin resistance induced (mTNFα 10 ng/mL for 6 days)⋅Anthocyanin-rich purple corn water extract (PCW; 0.4
Insulin 68384 days)⋅Anthocyanin-rich purple corn water extract (PCW; 0.4 mg dry sample/mL; exposure time unknown)⋅ Insulin sensitivity measured via glucose uptake (2-NBDG assay)⋅PCW ↑ glucose uptake vs. vehicle in insulin
Insulin 69321 [[49]]↑ [[49]]Anthocyanins3T3-L1 cells↑ [[53]]↓ [[60]]Diabetic rats↑ [[38]]SoybeanIsoflavones Insulin resistant rats↓ [[1]]↑ [[1]]↑ [[1]]↓ [[1]]Lean & obese rats↓ [[64]]C57BL/6 mice↑ [[70]]Insulin
Insulin 69428 resistant rats↓ [[1]]↑ [[1]]↑ [[1]]↓ [[1]]Lean & obese rats↓ [[64]]C57BL/6 mice↑ [[70]] Insulin resistant, menopausal monkeysX [[80]]GalactooligosaccharidesMini-piglets↑ [[86]]ChickpeaIsoflavones3T3-L1
dexamethasone 13009 as glucose uptake [[50],[51]]. Insulin resistance was induced in the preadipocytes by treating with dexamethasone and insulin for 60 h (eight days is required to obtain mature adipocytes under the culture conditions),
dexamethasone 66874 al. [[49]]⋅3T3-L1 preadipocytes⋅Differentiated post-confluence⋅Insulin resistance induced (1 mM dexamethasone , 10% fetal bovine serum, 10 mg/L insulin for 2 days)⋅Vehicle (0.1% dimethyl sulfoxide (DMSO))⋅Black
Select Disease Character Offset Disease Term Instance
hyperglycemia 50721 and women (mean age range 43–53 years old)⋅Overweight (body mass index 25.0–29.9 kg/m2)⋅Mild hyperglycemia (fasting blood glucose 5.5–6.9 mmol/L)⋅Placebo: 2 g starch capsules/day⋅Positive control: 300
metabolic syndrome 765 (collection): 4/2018AbstractInsulin resistance is a major risk factor for diseases such as type 2 diabetes and metabolic syndrome . Current methods for management of insulin resistance include pharmacological therapies and lifestyle
metabolic syndrome 2412 is well known that insulin resistance is a condition that lays the foundation for diseases such as metabolic syndrome , type 2 diabetes, and cardiovascular disease [[1]]. As the precursor to the onset of overt disease,
obesity 18983 preadipocytes may prevent the development of large, dysfunctional adipocytes commonly associated with obesity and insulin resistance [[63]]. Therefore, by inhibiting lipid accumulation, isoflavones are improving
obesity 19510 PPAR-γ.4.3. Fat Deposition & MetabolismWith chronic excess energy consumption, such as that associated with obesity , triglycerides and other lipid metabolites spill over into non-adipose tissues such as the liver and

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