Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
obesity 49 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
diabetes mellitus 2 endocrinologydiseases
glucose intolerance 2 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
hyperlipidemia 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 32047 allicin). The effect of garlic on different medical conditions (such as hypertension, hyperlipidemia, diabetes mellitus , rheumatic disease, the common cold, arteriosclerosis, and cancer) has been widely investigated. Garlic
diabetes mellitus 41842 increase in expression of myosin light-chain kinaseCurcumin attenuates WD-induced development of type 2 diabetes mellitus and atherosclerosis[[194]]StilbenesResveratrolKunming miceHF microbiomes were clearly different from
glucose intolerance 18462 [89]]; naringenin regulates lipid and glucose metabolism [[71]] and also prevents hepatic steatosis and glucose intolerance [[90]] by suppressing macrophage infiltration into the adipose tissue [[91]]. In addition, both compounds
glucose intolerance 41351 diseasesSignificantly attenuated the Western diet-induced increase in plasma LPS levelsSignificantly reduced WD-induced glucose intolerance and atherosclerosis[[193]]CurcuminHuman IEC lines Caco-2 and HT-29Curcumin modulates chronic inflammatory
hyperinsulinemia 44724 acids, LDL-cholesterol, and lactate. While Pic tended to improve lipid handling, it did not mitigate hyperinsulinemia and cardiac hypertrophy[[155]]Organosulfur compoundsGEO (garlic essential oil)DADS (DiAllyl DiSulfide)C57BL/6
hyperlipidemia 32031 derived agent, allicin). The effect of garlic on different medical conditions (such as hypertension, hyperlipidemia , diabetes mellitus, rheumatic disease, the common cold, arteriosclerosis, and cancer) has been widely
metabolic syndrome 3009 inflammation constituting a well-known risk factor for multiple pathological conditions, including metabolic syndrome and insulin resistance [[1]], and it has also been implicated as a proactive factor and associated with
obesity 1741 pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health.
obesity 1966 reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical
obesity 2566 evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that
obesity 2821 constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases.1. IntroductionObesity is a chronic state of low-grade inflammation constituting
obesity 3368 the last decade report interest in fermentation products from gut microbiota (GM) in the control of obesity and related metabolic disorders [[3]]. GM denotes an entire ecosystem inhabiting each organism, thus
obesity 4344 infectious diseases, gastrointestinal cancers, cardiovascular disease, inflammatory bowel disease, and even obesity and diabetes [[7], [8]]. Additionally, a pathological state can cause an imbalance in this microbial
obesity 6999 phytochemicals, like nutraceuticals that can influence GM, are being studied as coadjuvants to treat obesity and inflammatory diseases. In this review, we will present, organize, and discuss the most recent evidence
obesity 7191 the most recent evidence that points to a relationship of the phytochemical effect on GM that affects obesity and/or inflammation, focusing on the effect of phytochemicals as potential prophylactics and candidates
obesity 10807 attracted interest in the media and in the research community because of their potential role in reducing obesity , an increasingly serious health issue in different population age ranges [[37], [38]]. Polyphenols such
obesity 12683 Staphylococcus spp. [[47], [48]]. Consequently, phytochemicals that affect the balance of the GM may influence obesity and inflammatory diseases.Therefore, through the modulation of GM, polyphenols have the potential to
obesity 13164 focus on specific polyphenols that have been reported as able to affect GM and, in addition, influence obesity and/or inflammation.3. Experimental Nutritional Interventions with Phytochemicals That Modify Gut Microbiota
obesity 13816 phytochemicals in experimental models (mainly polyphenols), which are able to modify GM and exert an effect on obesity and/or inflammatory parameters, in order to analyze and discuss their potential use for the prophylaxis
obesity 13945 parameters, in order to analyze and discuss their potential use for the prophylaxis and treatment of obesity and inflammatory diseases by the maintenance and control of GM.To compile the information from scientific
obesity 14918 searches the following terms: “anti-inflammatory OR antiinflamatory” on one subsequent search, or “ obesity ” for another search. In both cases, the numbers of articles were scarce with a total of 116 and 71,
obesity 15361 the indication of a relationship among the effects of different phytochemicals on the GM that affects obesity and/or the immune response (Table 1).3.1. FlavonoidsThe first and largest subgroup of polyphenols is
obesity 16622 modulate the angiogenic process [[57]], and the majority of these have been recently involved with obesity [[58], [59]].3.1.1. FlavonesNumerous studies have been undertaken on the influence of GM on the intestinal
obesity 17148 [[68], [69]], and chrysin [[34]]. Furthermore, recent studies involve apigenin with the amelioration of obesity -related inflammation [[70]] and regulating lipid and glucose metabolism [[71]], luteolin with the amelioration
obesity 17270 inflammation [[70]] and regulating lipid and glucose metabolism [[71]], luteolin with the amelioration of obesity -associated insulin resistance, hepatic steatosis and fat-diet-induced cognitive deficits [[72]–[75]],
obesity 17775 there is still no study that considers together these following three aspects: GM, inflammation, and obesity as positively affected by these flavones. Consequently, this constitutes a whole new avenue for studying
obesity 18284 [[85]–[87]]. Additionally, they influence lipid metabolism as a potential preventive strategy for obesity . For instance, hesperetin exhibits lipid-lowering efficacy [[88], [89]]; naringenin regulates lipid
obesity 18938 of this evidence strongly indicates that these compounds can be usefully applied to prevent or treat obesity and its associated inflammation, but it is relevant to take GM into account in order to incorporate
obesity 20053 against alcohol injury by reducing endoplasmic reticulum stress and DNA damage [[98]] and exhibits an anti obesity effect [[99]]; naringin also influences the lipid profile and ameliorates obesity [[100]], and finally,
obesity 20135 and exhibits an antiobesity effect [[99]]; naringin also influences the lipid profile and ameliorates obesity [[100]], and finally, baicalein regulates early adipogenesis by inhibiting lipid accumulation and m-TOR
obesity 20446 together, that is, GM metabolism of the polyphenols and their specific effect on lipid metabolism, obesity , and inflammation.3.1.4. FlavanolsThis subgroup mainly comprises catechins, which are more abundant
obesity 21370 with GM and their anti-inflammatory actions [[107]], as well as their role in lipid metabolism and obesity [[105], [108]]. Among the compounds included in this group, we find the following: catechin, epicatechin,
obesity 21722 of their relationship between GM and inflammation, as well as that related with lipid metabolism and obesity (see Table 1 for specific examples). However, much work remains to ascertain the mechanisms by which
obesity 21979 health.3.1.5. FlavonolsCompounds in this subgroup have also been studied as related with GM and inflammation or obesity , mainly quercetin and kaempferol, while another three, rutin, myricetin, and isohamnetin, have not to
obesity 22686 increase our knowledge on the relationships already mentioned among phytochemicals, GM, inflammation, and obesity . Therefore, this subgroup constitutes that of the leading compounds in the study of the relationship
obesity 23532 knowledge there is a lack of research regarding the possible effects of this subgroup of flavonoids on obesity and/or inflammation through their effect on GM.3.1.7. IsoflavonesThis subgroup has been partially studied
obesity 23686 GM.3.1.7. IsoflavonesThis subgroup has been partially studied with relation to GM and inflammation or obesity . It is made up of phytoestrogens, which are mainly present in soybeans. Isoflavones are metabolized
obesity 25030 further studies regarding their metabolism by GM in relation with inflammation and lipid metabolism for obesity .3.1.8. AnthocyaninsAnthocyanins are a class of flavonoids that are ubiquitously found in fruits and
obesity 26022 fewer than 70 papers that correlate at least one of these compounds with anti-inflammatory activity or obesity (or lipid metabolism), there are only a dozen papers, to our knowledge, which correlate any of these
obesity 26734 diversity of diseases, including hepatic disorders, respiratory conditions, and inflammation and also obesity , diabetes, rheumatism, and even certain tumors. One relevant aspect to notice is that even at very high
obesity 27634 anti-inflammatory and neuroprotective agent [[143], [144]], as well as a possible factor for the treatment of obesity [[145]–[147]]. The research on curcumin is extensive; notwithstanding, there are still very few papers
obesity 27864 the relationship of curcumin metabolism by GM, its action over intestinal permeability, and effect on obesity and/or inflammation (Table 1).3.3. Stilbenes3.3.1. ResveratrolThe third subgroup of polyphenols comprises
obesity 28877 anti-inflammatory effect of resveratrol which has been widely reported [[151]], as well as its anti obesity effect [[152]]. Regarding the GM effect, resveratrol favored the proliferation of Bifidobacterium and
obesity 29643 Some studies analyze the effect of resveratrol on GM combined with their anti-inflammatory and anti obesity actions (Table 1). It constitutes a good example of the potential that the profound study of phytochemicals
obesity 30303 biomolecule for pharmacological use [[59]]. Recently, Hijona et al. [[155]] studied its beneficial effects on obesity . Although these are limited, it constitutes a promissory phytochemical molecule.3.4. Organosulfur Compounds3.4.1.
obesity 31585 attracted the attention of researchers as sources of novel drugs and drug leads for the treatment of obesity [[159]–[161]]. Allium species have been used in herbolary or traditional medicine for the treatment
obesity 31793 treatment of metabolic diseases, and Allium-derived extracts have recently become of interest for their anti obesity effects [[162]].The chemical constituents of garlic are enzymes (asalliinase) and organosulfur compounds
obesity 37065 bioavailability, metabolism, and effects on carbohydrate and lipid metabolism, and therefore their use in treating obesity and inflammatory diseases.Figure 1Chemical structure of representative molecules for the four main polyphenol
obesity 37339 flavonoid subgroups.Figure 3Phytochemicals that affect gut microbiota with anti-inflammatory and/or anti obesity properties.Table 1Effects of different phytochemicals on GM and/or obesity with anti-inflammatory actions.PhytochemicalsCompoundModelEffect
obesity 37414 anti-inflammatory and/or antiobesity properties.Table 1Effects of different phytochemicals on GM and/or obesity with anti-inflammatory actions.PhytochemicalsCompoundModelEffect on gut microbiotaAntioxidant and anti-inflammatory
obesity 37554 actions.PhytochemicalsCompoundModelEffect on gut microbiotaAntioxidant and anti-inflammatory effectEffect on obesity RefPolyphenolsC57BL/6 J ApcMin miceBacterial diversity was higher in the bilberry group than in the
obesity 38178 in HFD + EGCG but higher in control diet + EGCGPotential use for prevention, or therapy, for obesity -related and oxidative stress-induced health risks[[185]]Epigallocatechin-3-gallateC57BL/6 J miceRegulates
obesity 38389 miceRegulates the dysbiosis and maintains the microbial ecology balanceSignificant protective effect against obesity induced by high-fat diet (HFD)[[186]]Epigallocatechin-3-gallateWistar ratsEGCG affects the growth of
obesity 39084 inflammasome response and reticulum stress pathway activationBenefits gut-liver axis activation associated to obesity , leading to the blockage of lipid metabolism gene expression deregulation[[109]]QuercetinWistar ratsQuercetin
obesity 39345 Firmicutes/Bacteroidetes ratio and inhibiting the growth of bacterial species previously associated to diet-induced obesity (Erysipelotrichaceae, Bacillus, Eubacterium cylindroides). Quercetin was effective in lessening high-fat
obesity 45065 capacity via inhibition of cytochrome P450 2E1 expressionGEO and DADS dose-dependently exerted anti obesity and antihyperlipidemic effects by reducing HFD-induced body weight gain, adipose tissue weight, and
type 2 diabetes mellitus 41835 subsequent increase in expression of myosin light-chain kinaseCurcumin attenuates WD-induced development of type 2 diabetes mellitus and atherosclerosis[[194]]StilbenesResveratrolKunming miceHF microbiomes were clearly different from

You must be authorized to submit a review.