Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis.

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osteoporosis 82 Title: BMC Endocrine DisordersAssociations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysisHeping
osteoporosis 514 studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present
osteoporosis 717 the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women.MethodsPubMed, EMBASE, Web of Science, the Cochrane Library
osteoporosis 2140 polymorphism might have different impact on PMOP risk and BMD in various ethnicities.BackgroundPostmenopausal osteoporosis (PMOP) is a common metabolic bone disorder characterized by low bone mineral density (BMD) and increased
osteoporosis 2307 characterized by low bone mineral density (BMD) and increased fracture risks [[1]–[3]]. It is estimated that osteoporosis affects approximately 10 million American adults, with another 34 million being at high risk due to
osteoporosis 3163 ovarian production of estrogen after menopause is a cause for the initial phase of rapid bone loss and osteoporosis in women [[3]]. Estrogen is known as an important regulator of bone metabolism, and estrogen deficiency
osteoporosis 5260 ERα G2014A (rs2228480)] ERβ gene polymorphisms [ERβ AluI (rs4986938) and ERβ RsaI (rs1256049)] and osteoporosis susceptibility and BMD in postmenopausal women by using the following search terms (‘PMOP’ OR ‘Postmenopausal
osteoporosis 5389 and BMD in postmenopausal women by using the following search terms (‘PMOP’ OR ‘Postmenopausal osteoporosis ’ OR ‘Postmenopausal’) AND (‘Estrogen Receptor’ OR ‘ER’) AND (‘polymorphism’ OR ‘single
osteoporosis 5704 ER gene polymorphisms on BMD, the following search terms were used: (‘PMOP’ OR ‘Postmenopausal osteoporosis ’ OR ‘Postmenopausal’) AND (‘Estrogen Receptor’ OR ‘ER’) AND (‘polymorphism’ OR ‘single
osteoporosis 7907 95% confidence interval (CI) to evaluate the association between ER gene polymorphisms and PMOP risk ( osteoporosis occurred in postmenopausal women due to estrogen deficiency as represented by low BMD and increased
osteoporosis 11104 showing the process of selectionTable 1General characteristics of studies assciated with postmenopausal osteoporosis riskAuthorYearEthnicitySample SizeERα XbaIHWECaseControlCaseControlXxXXXxxxXxXXXxxxShang et al.2016Asian1982763385814646610944310891770.77Wang
osteoporosis 19607 of genetic models for ERα XbaI, ERα PvuII, ERα G2014A, ERβ AluI and ERβ RsaI polymorphisms and osteoporosis susceptibility in postmenopausal womenComparisonNTest of associationModelTest of heterogeneityBegg’s

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