Hypothalamic hypopituitarism secondary to suprasellar metastases from small cell lung cancer: a case report and review of the literature

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hypoglycemia 3 endocrinologydiseases
hypopituitarism 33 endocrinologydiseases
testosterone 1 endocrinologydiseasesdrugs
cortisol 4 endocrinologydiseasesdrugs
diabetes insipidus 3 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
cortisol 8836 range, 142.4–923.1), adrenocorticotropic hormone (ACTH) 5.6 pg/ml (reference range, 7.2–63.3), and cortisol 0.2 μg/dl (reference range, 4.5–21.1). The results showed a TSH response to thyrotropin-releasing
cortisol 9049 hormone: serum TSH 4.526 μIU/ml at 30 min and 4.591 μIU/ml at 60 min. We demonstrated an adequate cortisol and ACTH response to corticotropin-releasing hormone: serum cortisol was 5.6 μg/ dl at 60 min and
cortisol 9118 60 min. We demonstrated an adequate cortisol and ACTH response to corticotropin-releasing hormone: serum cortisol was 5.6 μg/ dl at 60 min and had a peak of 5.7 μg/ dl at 90 min, whereas serum ACTH showed a peak
cortisol 11563 reevaluated the hormone loading test on day 59 after admission, which revealed an improvement in ACTH and cortisol secretions (Fig. 5b). We also performed a brain MRI in T2 star-weighted sequences again on day 62, which
testosterone 8693 (LH) < 0.1 mIU/ml (reference range, 1.2–7.1), prolactin 37.9 ng/ml (reference range, 3.6–12.8), testosterone < 4.3 ng/dl (reference range, 142.4–923.1), adrenocorticotropic hormone (ACTH) 5.6 pg/ml (reference
Select Disease Character Offset Disease Term Instance
diabetes insipidus 11193 the symptoms of lethargy, loss of appetite, and hypotension were improved. There was no evidence of diabetes insipidus during those therapies. The patient’s clinical stage was stage IV (cT3N2M1b), and his performance
diabetes insipidus 14385 arteries. For these reasons, the most common symptom of hypopituitarism due to metastasis seems to be diabetes insipidus [[6]]. The presence of visual loss and anterior pituitary insufficiency, though common symptoms of pituitary
diabetes insipidus 17471 In addition, those symptoms are often confused with the presentations of cancer itself. In addition, diabetes insipidus was present in seven cases. The most significant underlying condition was heavy cigarette smoking, which
diabetes mellitus 3852 our patient.Case presentationA 67-year-old Japanese man with a past medical history of hypertension, diabetes mellitus , and angina presented with a history of generalized weakness, lethargy, cold intolerance, weight loss,
hypoglycemia 936 presented to our hospital with generalized weakness, lethargy, and weight loss. Laboratory data showed hypoglycemia together with low thyroid-stimulating hormone and free thyroxine. We suspected hypopituitarism and performed
hypoglycemia 5113 were normal. Biochemistry tests revealed a sodium level of 134 mEq/L (reference range, 135–147) and hypoglycemia , but the other electrolytes were within normal limits. Notably, the level of thyroid-stimulating hormone
hypoglycemia 5688 The echocardiogram revealed no abnormalities. We suspected hypopituitarism based on the patient’s hypoglycemia , hypotension, nonelevated TSH, and low FT4, and also based on the results of head computed tomography
hypopituitarism 51 Title: Journal of Medical Case ReportsHypothalamic hypopituitarism secondary to suprasellar metastases from small cell lung cancer: a case report and review of the literatureRyohei
hypopituitarism 691 rarely been reported in the literature. To the best of our knowledge, only nine cases of hypothalamic hypopituitarism due to metastases of solid tumors have been reported in English-language journals.Case presentationA
hypopituitarism 1028 showed hypoglycemia together with low thyroid-stimulating hormone and free thyroxine. We suspected hypopituitarism and performed imaging of the head, which revealed multiple tumors, one of which was in the suprasellar
hypopituitarism 1332 biopsy pathologically showed small cell lung cancer. Hormone profiling demonstrated hypothalamic pan- hypopituitarism . We diagnosed hypothalamic hypopituitarism secondary to metastases from the primary lung cancer and
hypopituitarism 1375 cancer. Hormone profiling demonstrated hypothalamic pan-hypopituitarism. We diagnosed hypothalamic hypopituitarism secondary to metastases from the primary lung cancer and initiated radiation, chemotherapy, and hormone
hypopituitarism 1613 the patient died 10 months later.ConclusionsWe report a case of a 67-year-old man with hypothalamic hypopituitarism secondary to a suprasellar metastasis from a primary small cell lung cancer, and we review ten cases
hypopituitarism 1746 suprasellar metastasis from a primary small cell lung cancer, and we review ten cases of hypothalamic hypopituitarism due to metastases, including our patient. Recognizing hypopituitarism can be challenging, especially
hypopituitarism 1816 review ten cases of hypothalamic hypopituitarism due to metastases, including our patient. Recognizing hypopituitarism can be challenging, especially in the elderly, whose symptoms such as lethargy and visual decline may
hypopituitarism 2155 wrongly attributed to malignancy or to the side effects of therapy. When a patient is suspected of having hypopituitarism , a hormone load test can help to diagnose the type of hypopituitarism. It is important to evaluate the
hypopituitarism 2225 patient is suspected of having hypopituitarism, a hormone load test can help to diagnose the type of hypopituitarism . It is important to evaluate the brain and the whole body to confirm whether metastasis and primary
hypopituitarism 2488 very high, aggressive intervention for both diagnosis and therapy is required in cases of hypothalamic hypopituitarism secondary to tumor metastasis.BackgroundMetastasis to the pituitary gland is an infrequent clinical
hypopituitarism 2737 by the metastases are reported in only 2.5–18.2% of the cases [[1]]. The clinical presentation of hypopituitarism is often insidious, being characterized by nonspecific manifestations, such as weight gain, fatigue,
hypopituitarism 3414 suprasellar region has rarely been reported. To the best of our knowledge, only nine cases of hypothalamic hypopituitarism due to metastases of solid tumors have been reported in English-language journals to date. We report
hypopituitarism 3577 reported in English-language journals to date. We report a case of a 67-year-old man with hypothalamic hypopituitarism secondary to a suprasellar metastasis from a primary small cell lung cancer and review ten cases of
hypopituitarism 3706 a suprasellar metastasis from a primary small cell lung cancer and review ten cases of hypothalamic hypopituitarism due to metastasis, including our patient.Case presentationA 67-year-old Japanese man with a past medical
hypopituitarism 5647 conduction or repolarization abnormalities. The echocardiogram revealed no abnormalities. We suspected hypopituitarism based on the patient’s hypoglycemia, hypotension, nonelevated TSH, and low FT4, and also based on
hypopituitarism 9644 at 60 min, and peak of 2.1 mIU/ml at 90 min (Fig. 5a). Those results suggested hypothalamic pan- hypopituitarism .Fig. 5Hormone load test on day 4 (a) and on day 59 (b)Tumor markers demonstrated elevated pro-gastrin-releasing
hypopituitarism 10887 × 400 magnification. f Synaptophysin immunostain, × 400 magnificationWe made a diagnosis of pan- hypopituitarism secondary to suprasellar metastases from a small cell lung cancer and first initiated hormone replacement
hypopituitarism 12148 presented with generalized weakness, lethargy, and weight loss and was later diagnosed with hypothalamic hypopituitarism secondary to metastases from the primary lung cancer. He underwent radiation therapy followed by chemotherapy
hypopituitarism 12437 What is unique to our patient’s case compared with previously reported cases is that hypothalamic hypopituitarism was confirmed by a hormone loading test, and we performed it again to assess the therapeutic effects.
hypopituitarism 12616 again to assess the therapeutic effects. Due to limited literature in regard to cases of hypothalamic hypopituitarism , it was challenging to develop an evidence-based treatment. However, our case was successful because
hypopituitarism 13345 primary tumor metastases to the pituitary is followed by lung cancer (23.7%) [[1]]. Recognition of hypopituitarism can be challenging, especially in the elderly, whose symptoms such as lethargy and visual decline may
hypopituitarism 14339 posterior lobe is supplied by the hypophyseal arteries. For these reasons, the most common symptom of hypopituitarism due to metastasis seems to be diabetes insipidus [[6]]. The presence of visual loss and anterior pituitary
hypopituitarism 14605 pituitary adenoma, are less commonly seen with pituitary metastasis [[7]].There are two main types of hypopituitarism according to the pituitary or hypothalamic lesions. Even though pituitary hypopituitarism is relatively
hypopituitarism 14695 types of hypopituitarism according to the pituitary or hypothalamic lesions. Even though pituitary hypopituitarism is relatively rare, only ten cases of hypothalamic hypopituitarism secondary to metastases of solid
hypopituitarism 14762 hypothalamic lesions. Even though pituitary hypopituitarism is relatively rare, only ten cases of hypothalamic hypopituitarism secondary to metastases of solid tumors (including our patient) have been reported in English-language
hypopituitarism 15475 opposite that in the previous review we mentioned above [[1]].Table 2Clinical features of hypothalamic hypopituitarism secondary to metastasis reported in the literaturePatientReferenceAge (years)SexPredisposing factorPrimary
hypopituitarism 17687 smoking, which was reported in three cases, all of which were accompanied by lung cancer.When hypothalamic hypopituitarism is present, radiotherapy or chemotherapy should be initiated with the least possible delay. The high
hypopituitarism 17869 the least possible delay. The high mortality rate is associated with reported cases of hypothalamic hypopituitarism , and the survival time after diagnosis was at most 10 months, with one case having a survival time
hypopituitarism 18316 and we could not control the progression of the systemic symptoms.ConclusionsIn summary, hypothalamic hypopituitarism is a very rare condition, and the diagnosis is difficult because of the nonspecific symptoms. When the
hypopituitarism 18466 diagnosis is difficult because of the nonspecific symptoms. When the patient is suspected of having hypopituitarism , a hormone load test can help to diagnose the type of hypopituitarism. It is also important to evaluate
hypopituitarism 18536 patient is suspected of having hypopituitarism, a hormone load test can help to diagnose the type of hypopituitarism . It is also important to evaluate the brain and the whole body to confirm whether metastasis and primary
hypopituitarism 18804 very high, aggressive intervention for both diagnosis and therapy is required in cases of hypothalamic hypopituitarism secondary to the metastasis

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